N/A N=1,635 Breast Cancer Risk Reduction: A Patient Doctor Intervention
Breast Cancer
Primary: Knowledge of Breast Cancer Risk Factors — 48.9; 56.4 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=304 Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
HIV · Opioid Dependence
Primary: Demonstrated Drug Risk Reduction Skills (0-100%) — 40.60; 42.75 Percentage of correct steps
Phase 3 N=8,231 "REDUCE" - A Clinical Research Study To Reduce The Incidence Of Prostate Cancer In Men Who Are At Increased Risk
Neoplasms, Prostate
Primary: Number of Participants With Biopsy-detectable Prostate Cancer at Years 2 and 4 (Crude Rate Approach) — 578; 435; 280; 224 participants — p=<0.0001
Phase 2 N=59 Reducing HIV Risk Among Episodic Substance Using Men Who Have Sex With Men (SUMSM)
HIV Infections · Episodic Substance Use
Primary: Total Unprotected Anal Intercourse Events (Exclusive of Those Events With a Primary HIV-negative Partner) — 4.23; 3.91; 3.41; 2.05 Self reported events in past 3 months
Phase 3 N=5,451 Strategies to Reduce Injuries and Develop Confidence in Elders
Accidental Falls · Wounds and Injuries
Primary: First Adjudicated Serious Fall-Related Injury — 4.87; 5.34 events per 100 person years of follow-up — p=0.245
N/A N=511 Sustainable HIV Risk Reduction Strategies for Probationers
Health Behavior
Primary: HIV Knowledge Confidence — 42.9; 40.5 units on a scale — p=<.001
N/A N=127 Cocaine Use Reduction and Health
Cocaine Use Disorder
Primary: Endothelin-1 Levels — 2.15; 2.063; 1.956 pg/ml
N/A N=72 Prevention of Alcohol-related Sexual Revictimization in College
Sexual Assault
Primary: Days Per Month Hazardous Drinking — 7.54; 10.40; 1.97; 1.53 Days per Month Hazardous Drinking — p=<0.99
N/A N=172 Systematic Multi-domain Alzheimer's Risk Reduction Trial
Dementia · Alzheimer Disease
Primary: Cognitive Change — 0.34; 0.19 z-score — p=0.008
N/A N=43 Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)
Methicillin-resistant Staphylococcus Aureus
Primary: Main Outcome: Patients With Nosocomial MRSA Clinical Cultures — 0.92; 0.75; 0.63 hazard ratio — p=0.01
N/A N=450 Reducing Treatment Risk in Older Adults With Diabetes
Type 2 Diabetes Treated With Insulin · Hypoglycemia · Primary Health Care
Primary: Clinical Outcome: Number of Participants With Glycemic Regimen De-prescribing — 34; 21 Participants
N/A N=13,381 Prioritized Clinical Decision Support (CDS) to Reduce Cardiovascular Risk
Hypertension · Hyperlipidemia · Diabetes
Primary: Predicted Annual Rate of Change in 10-year Risk of Fatal or Nonfatal Heart Attack or Stroke — -0.59; 1.66 annualized change in 10 year % cv risk — p=<0.05
N/A N=63 Reduced Radiation in Patients With Diffuse Large B-cell Lymphoma
Diffuse Large B-cell Lymphoma
Primary: Number of Participants With Local Control — 61 Participants
N/A N=464 Tailored Communication to Reduce Cardiovascular Risk
Hypercholesterolemia · Coronary Artery Disease · Dyslipidemia
Primary: Comparative Outcomes: Intervention Group LDL Reduction Compared to Control Group LDL Reduction — 11.0; 11.1 % of patients with major LDL reduction — p=0.99
N/A N=260 Drug Reduction in Older Patients: The DROP Trial
Geriatric Assessment · Frail Elderly · Skilled Nursing Facilities
Primary: Total Number of Medications — 15; 13; 15.5; 14 Medications — p=0.006
N/A N=881 Efficacy of a Web-based Sexual Violence Risk Reduction Program for Female College Students
Sexual Violence
Primary: Change From Baseline in Sexual Violence Victimization at 6-months Follow-up — 5.64; 5.68; 5.52; 8.15 score on a scale — p=.0002
N/A N=104 rPlan Multimedia Dual Protection Intervention to Reduce Health Disparities
Sexually Transmitted Infection
Primary: Change in Frequency of Recent Dual Method Use — 3.17; 3.45 score on a scale — p=.177
Phase 4 N=61 Virological and Immunological Safety of a Dose Reduction Strategy Antiretroviral Regimen With Efavirenz / Tenofovir / Emtricitabine
HIV
Primary: Proportion of Patients Free of Treatment Failure (Noncompleter = Failure) at 24 Weeks. — 30; 31; 0; 0 Participants
N/A N=987 Reducing Pesticide Exposures in Child Care Centers
Children, Only · Risk Reduction · Environmental Exposure
Primary: Decrease in Child Care Center Pesticides — 1.95; 1.87; 0.59; 0.53 log10(ng/g) — p=<0.05
N/A N=327 Community-Based, Client-Centered Prevention Homes to Address the Rural Opioid Epidemic- Aim 3
Drug Use Disorders · Hepatitis C · Harm Reduction
Primary: Change in the Addiction Treatment Accessibility and Utilization as Assessed by Change in Likert Scale — 1.26; 1.07; 1.12; 1.03 score on a scale — p=0.84
N/A N=156 Eliminating Risk of Preventable Adverse Drug Events at the Hospital-community Interface of Care
Adverse Drug Events
Primary: Health Services Utilization 3 Months Following Hospital Discharge — 3.33; 3.40 Health Services Utilizations — p=.87
Phase 2 N=584 Behavioral Intervention to Reduce Sexual and Injection Risks Among Female Sex Workers Who Also Inject Drugs in Mexico
HIV · HIV Infections
Primary: Combined HIV/STI 12-month Incidence Rates of HIV, Syphilis, Chlamydia, Gonorrhea and Trichomonas Vaginalis. — 65.02; 67.66; 35.02; 54.04 incidence density per 100 person…
N/A N=594 Reduction in IV Associated Contamination
Post-operative Infections
Primary: Presence of Bacterial IV Stopcock Lumen Contamination — 41; 32 percent stopcock contamination rate
N/A N=305 Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace
Substance-Related Disorders
Primary: Estimated Cigarettes Taken at Free Price Derived From the Cigarette Purchase Task — 1.50; 1.45; 1.47; 1.45 Cigarettes (log transformed)
N/A N=4,350 Reducing Diagnostic Errors in Primary Care Pediatrics (Project RedDE)
Diagnostic Errors
Primary: Number of Adolescents Diagnosed With Depression Seen in Well Child Visits — 233; 443 Participants — p=<0.0001
N/A N=6,009 Cardiovascular Risk Screening and Risk Reduction in Women Vets
Cardiovascular Diseases · Hypertension · Hyperlipidemias
Primary: New Participation in MOVE! (Among Women Aged 65 and Older) — 1.09 Odds Ratio — p=.003
N/A N=10,347 Reducing Cardiovascular Risk in Adults With Serious Mental Illness
Chronic Disease · Mental Disorder · Health Behavior
Primary: Predicted Annual Rate of Change in 10 Year Risk of Fatal or Nonfatal Heart Attack or Stroke — 14.2; 20.8 percentage of annual rate of change
N/A N=136 X-ray Dose Reduction in Electrophysiology
Arrhythmias, Cardiac
Primary: Cumulative Dose Area Product (DAP) Value — 8.8; 15.3 Gy*cm^2 — p=<0.0001
N/A N=2,622 Effectiveness of an Online Prevention Program in Reducing the Risk of STD Infection in Young Adults
HIV Infections · Sexually Transmitted Diseases
Primary: Efficacy of Internet-based Program for Increasing Condom Use With Non-main Sex Partners — .68; .56 percentage of sex acts protected by cond
N/A N=40 Reduction of Risk Factors for ACL Re-injuries Using a Novel Biofeedback Approach
Anterior Cruciate Ligament Injury
Primary: Change in Peak Knee Extension Moment Symmetry — 50.1; 44.2; 44.6; 40.6 % Symmetry