Phase 2 N=345 Non-invasive Treatment of Root Caries in Older Adults
Root Caries
Primary: Root Caries Activity — 3.72; 40.52 Percentage of active lesions (2-years)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=323 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
Dental Caries
Primary: Number of New Tooth Root Caries Lesions — 1.1; 0.43; 0.56 new carious root surfaces
Phase 3 N=983 Prevention of Adult Caries Study (PACS)
Caries, Dental
Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…
Phase 3 N=394 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Dental Caries
Primary: ICDAS Severity Value — 17; 22; 278; 273 teeth — p=0.1126
N/A N=17 Radiographic Progression of Infiltrated Caries Lesions In-vivo
Dental Caries
Primary: Number of Lesions Showing Radiographic Progression as Measured by Lesion Size (Continuous) — 2; 11 Lesions — p=0.002
Phase 2 N=70 Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Dental Caries
Primary: Caries Activity and Progression Assessment Using LASER Fluorescence Readings by Diagnodent® Device. — 18.6; 1.1 units on a scale
Phase 4 N=20 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions
Caries
Primary: Change in Bacterial Composition Before and One Month After SDF Application to Root or Cervical Caries Lesions — 1890087; 1959306 bacterial count
Phase 3 N=169 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Caries · Dental Pulp Exposure
Primary: Parameters Evaluated After Treatment — 19; 19; 25; 3 Participants
N/A N=3,345 Comparative Effectiveness of Treatments to Prevent Dental Caries
Dental Caries
Primary: Number of Participants With Arrested Dental Caries, Assessed Using a Clinical Oral Examination — 48; 53 Participants
Phase 3 N=65 In Situ Caries Model of Fluoride Toothpastes
Caries
Primary: Percent Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to NaF Toothpaste (1426ppmF) and AmF Toothpaste (1400ppmF) — 38.05; 41.06 Percentage SMHR…
N/A N=169 European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth
Dental Caries
Primary: Failure Rate of the Three Treatment Arms Judged Clinically — 37; 31; 39; 2 Teeth — p=0.02
Phase 3 N=60 Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Individuals at High Risk
Cariostatic Agents · Mouthwashes
Primary: Change in Streptococcus Mutans Levels in Dental Plaque — 3.11; 0.93; 1.91; 2.23 log10CFU/g — p=0.123
N/A N=4 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material
Dental Pulp Diseases · Dental Pulp Necrosis · Nerve Root Pain Nec
Primary: Percent Reduction in Apical Radio-lucency — 17.4; 27.1 % Change in Diameter (mm)
N/A N=42 Resin Infiltration to Arrest Early Tooth Decay
Dental Caries
Primary: Number of Lesions With Progression as Measured by Pairwise (PW) Comparison (N=Lesions) — 4; 14 Lesions — p==0.003
N/A N=7,418 Comparative Effectiveness of School-based Caries Prevention
Dental Caries · Quality of Life
Primary: Proportion of Subjects With All Caries Arrested — 108; 101 Participants
N/A N=51 Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
Dental Caries in Children · Dental Caries Class II · Dental Caries
Primary: Interproximal Caries Zone of Radiolucency — 9; 7; 10; 12 Number of teeth
N/A N=50 Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Dental Caries · Denture, Partial, Removable
Primary: Mineral Loss ΔZ — 235; 774 vol% * μm]
Phase 3 N=57 In Situ Caries Efficacy of Fluoride Toothpastes
Caries
Primary: Percentage Surface Microhardness Recovery (%SMHR) of Sound Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and NaF Toothpaste (1400ppmF) — 28.31; 26.32 Percentage…
N/A N=98 Clinical Comparison of Vital Pulp Capping Restorative Protocols
Deep Dental Caries
Primary: Success Rate Based on Pulp Vitality Tests (Vital/Non Vital) — 96.2; 100; 100; 86 Percentage of success rate — p=>0.1
N/A N=60 Survival of Endocrowns Made From Different Ceramics
Pulp Disease, Dental · Dental Caries · Dental Leakage
Primary: Survival of Dental Prosthesis — 19; 14; 17 Teeth
Phase 4 N=60 Theracal Pulpotomy in Primary Molars
Deep Caries
Primary: Clinical Examination — 30; 30 Participants
Phase 3 N=48 Reducing Bacteria That Cause Tooth Decay
Caries, Dental · Cariostatic Agents
Primary: Microbial Levels — 11; 7; 15; 15 Participants — p=0.35
Phase 3 N=2,060 Preventing Caries in Preschoolers: Testing a Unique Service Delivery Model in American Indian Head Start Programs
Fluoride Varnish and Oral Health Promotion · Usual Care
Primary: Evaluation of Decayed, Missing, and Filled Tooth Surfaces (Dmfs) at Baseline — 19.9; 22.8 dmfs
Phase 3 N=60 In Situ Caries of Fluoride Toothpastes
Healthy Subjects · Partial Denture Wearers · Caries
Primary: Mean Percentage Surface Microhardness Recovery (%SMHR) of Enamel Specimens Exposed to NaF/Carbopol Toothpaste (1400 ppmF), NaF Toothpaste (1350ppmF) Compared to…
N/A N=525 Xylitol for Caries Prevention in Inner-City Children
Dental Caries
Primary: Change in the Number of Decayed or Filled Permanent Teeth (DFT) From Baseline (Beginning of Kindergarten) to the Middle of 2nd Grade — 0.38; 0.48 Number of surfaces…
Phase 2 N=70 MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial
Dental Caries · Dental Pulp Exposure
Primary: Comparison of MTA/FS Pulpotomy Versus RCT Treated Incisors With Acceptable Radiographic Outcome at 12 Months Post-procedure. — .97; .92 Proportion of incisors — p=.15
Phase 2 N=296 Effect of CPP-ACP Paste on Dental Caries in Primary Teeth
Dental Caries
Primary: the Mean Number of Enamel Carious Lesion — 13.69; 14.55 Surfaces
N/A N=282 Assessment of Caries Diagnosis and Caries Treatment in Dental PBRN Japan
Dental Caries
Primary: Percentage of Participants Who Indicate Surgical Intervention — 74 percentage of the dentists
N/A N=45 Efficacy of Three Toothpastes Using an in Situ Caries Model
Dental Caries
Primary: Percentage Surface Microhardness Recovery (SMHR) of Phyte (0% 0.425% and 0.85%) at 2 Weeks — 25.53; 26.81; 7.41; 28.88 % SMHR — p=0.7603
N/A N=150 Caries Prevention Effect of S-PRG Filler Incorporated in Denture Base Resins on Edentulous Elderly People
Dental Caries
Primary: Saliva Fluoride Concentration (Part Per Million,Ppm) — 0.05; 0.05; 0.09; 0.22 part per million,ppm — p=<0.05