Clinical Trial Search

Primary: Change From Open-label Baseline in Modified Scale for the Assessment of Negative Symptoms (SANS-18) Total Score at Week 10 Open-label Phase, Last Observation Carried…

Primary: Change From Baseline in the 16-Item Negative Symptoms Assessment (NSA-16) — -2.7; -3.6 units on a scale — p=0.732

Primary: Strauss-Carpenter Level of Function Scale — 97.69; 94.56 score on a scale

Primary: Scale for the Assessment of Negative Symptoms (SANS) — -.46; -.41 units on a scale/weeks

Primary: Wisconsin Card Sorting Test (WCST) — 38.43; 35.79; 43.14; 39.57 percentage of correct responses

Primary: Negative Symptom Assessment-16 (NSA-16) Total Score - Change From Baseline to Week 26 — -12.14; -11.09 score on a scale — p=0.4825

Primary: Change From Baseline in Negative Symptoms of Schizophrenia Measured by the Negative Symptom Assessment (NSA) Scale Total Score — 60.4; 61.3; -9.7; -9.2 Units on a Scale…

Primary: Change in Negative Symptoms — 32.7; 33.5; 31.2; 32.3 units on a scale

Primary: MATRICS Consensus Cognitive Battery (MCCB) — 30.92; 30.32; 33.43; 32.76 T score

Primary: Change From Baseline to Week 26 in the Negative Symptom Assessment-16 (NSA-16) Total Score — 61.8; 61.0; -10.5; -8.8 score on a scale — p=0.0434

Primary: PANSS Total — 77.9; 80 units on a scale — p=0.02

Primary: PANSS Negative Symptom Score — 21.5; 23 units on a scale — p=0.36

Primary: Clinical Assessment Interview for Negative Symptoms Motivation & Pleasure Scale (CAINS MAP) - 12 Weeks — 19.8; 17.3; 17.4; 17.1 score on a scale — p=0.295

Primary: Scale for the Asessment of Negative Symptoms (SANS) — 38.8; 53.7 Scores on a scale

Primary: Scale for the Assessment of Negative Symptoms (SANS) Total Score — 33.23; 36.63; 36.63; 30.07 units on a scale

Primary: Change in Persistent Positive Symptoms — 13; 14; 14; 14 units on a scale

Primary: Change in Positive and Negative Syndrome Scale (PANSS) - Total Score - Study Phases 1 and 2 — 83.6; 79.8; 77.6; 76.7 units on a scale — p=0.57

Primary: Wisconsin Card Sort Percent Perseverative Errors (Standard Score) — 87.54; 87.88; 91.80 standard score units — p=<.97

Primary: Change From Baseline in Modified Scale for the Assessment of Negative Symptoms (SANS 1-22 Composite Score) at Week 12 — -13.50; -10.91; -11.21 Score on a Scale — p=0.267

Primary: RVIP Target Hit and False Alarm (Number of Responses) — 23.4; 22.8; 19.7; 14.88 Number of responses — p=0.898

Primary: Social Affiliation Measured by Social Affiliative Role Play — 4.026; 4.111; 4.079; 4.194 units on a scale — p=0.758

Primary: Change From Baseline to Week 12 in PANSS Marder Negative Symptoms Factor Score (NSFS) — 25.2; 25.3; 24.3; -1.2 score on a scale — p=0.043

Primary: UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) — 82.7; 84.4 units on a scale

Primary: Change From Baseline on the PANSS NSFS at Week 12 — -3.1; -3.3; -3.4; -2.5 scores on a scale — p=0.426

Primary: Mean Score on the Scale for the Assessment of Negative Symptoms (SANS), p=0.048 — -10.38; -2.33 units on a scale — p=.048

Primary: Clinical Assessment Interview for Negative Symptoms (CAINS) — .0667; -.0588 score on a scale

Primary: Percent Change in Accuracy on High-control (i.e., Difficult) Condition of Preparing to Overcome Prepotency Task — 8.6; 9.2 percent change in accuracy

Primary: Mean Test Scores for Facial Emotion Identification. — 45.5; 41.1; 43.8; 45.1 number of correct answers — p=<.001

Primary: Change From Baseline on the Positive and Negative Syndrome Scale (PANSS) Positive Subscale — -2.4; -1.857; -5.889; -3.667 units on a scale

Primary: Change in Negative Symptoms of Schizophrenia as Measured on the PANSS — 16.9; 17.2 units on a scale — p=0.50