Clinical Trial Search

Primary: Number of Participants Who Died Within 7 Days After Discharge From the Emergency Department — 0; 0 participants

Primary: Mean Change From Baseline in Trough Sitting Systolic Blood Pressure (SiSBP) at Week 8 — -12.1; -6.8 mm Hg

Primary: Composite Adverse Perinatal Outcome — 353; 427; 272; 336 Participants — p=<0.001

Primary: Change From Baseline in Trough Seated Systolic Blood Pressure (SBP) at Week 8 — -47.5; -36.9; -43.2 mmHg (millimeters of mercury) — p=<0.0001

Primary: Mean Systolic Blood Pressure During Hour After Study Drug — 147; 152 mmHg

Primary: Proportion of Participants With Recorded Blood Pressure Values in Office — 43; 44; 49; 56 Participants

Primary: Number of Participants Assessed for Intensive (110-140 mm Hg) and Standard (155-165mm Hg) Pre-dialysis Standardized BP Goal — 62; 64 participants

Primary: Change Ambulatory Systolic Blood Pressure — -29.3 mmHg

Primary: Change From Baseline in Blood Pressure, as Measured by an Automated Oscillometric Blood Pressure Device. — -3.00; -6.67; -6.00; -7.67 mmHg

Primary: Clinically Significant Difference in Blood Pressure Lowering, Health Status and Quality of Life — -3.3; -4.9 mm Hg

Primary: Time to Achieve Non Severe Range Blood Pressure — 10; 20 minutes

Primary: Unadjusted and Adjusted Changes From Baseline in Systolic and Diastolic Blood Pressure at Weeks 1, 3, 6 — -1.2; -5.3; 0.8; -1.7 mmHg

Primary: Mean Systolic Blood Pressure (SBP) Difference at 6 Months Post-intervention Compared to Usual Care. — -9.2; -14.0 mmHg

Primary: Performance of Blood Pressure Referral Threshold — .841 proportion

Primary: Percent of Participants Eligible, Enrolled and Retained (Feasibility) — 61 Participants

Primary: Pregnancy Loss or NICU Admission for Greater Than 48 Hours — 155; 150 participants

Primary: Change From Baseline in Mean Seated Trough Cuff Systolic Blood Pressure (SBP) to Week 7 — -28.5; -37.0 mmHg — p=<0.0001

Primary: Adverse Events — 1; 1; 1; 1 participants

Primary: Number of Participants Whose Blood Pressure Was Assessed in the First Ten Days Following Discharge — 45; 95 Participants

Primary: Severity of Obstructive Sleep Apnea — -18.3; 7.0 events/hour

Primary: Office Systolic Blood Pressure Reduction — -31.7; 0.9 mmHg

Primary: SBP — 130.2; 128.8 mm Hg

Primary: Acute and Chronic Safety by Evaluating Incidence of Major Adverse Events — 204; 130; 2; 1 Participants

Primary: Particpants Who Achieve and Maintain the Systolic Blood Pressure Goals for Each Treatment Tier. — 18; 20; 22; 7 participants — p=< 0.01

Primary: Change in Mean Systolic Blood Pressure (SBP) — -10.58; -4.65 mmHg — p=<0.0001

Primary: Change in Exercise Pressor Reflex From Baseline — 8.67; 16.29 mmHG

Primary: Estimated Percentage of Participants in Blood Pressure Control at Baseline — 61; 59; 53; 64 % of particpants w/ controlled BP

Primary: Change in Mean Sitting Systolic Blood Pressure (msSBP) From Baseline to End of Study (Week 8) — -31.37; -27.99; -30.77; -37.92 mmHg

Primary: Change in Mean Sitting Systolic Blood Pressure After 6 Weeks — 166.8; 168.5; 135.5; 142.5 mmHg

Primary: Percentage of Participants With Adverse Events (AEs), Serious Adverse Events and Deaths — 20.0; 12.5; 33.3; 48.6 Percentage of participants