N/A N=170 Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress
Acute Psychological Stress
Primary: Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) — 0.265; 0.287 mL/(kg·min)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=28 Resolving Psychological Stress
Post-Traumatic Stress Disorder · Alcohol Use Disorder
Primary: PTSD Symptoms Using PTSD Checklist-5 (PCL-5) at Baseline and 15 Days — 33.2; 36.6; 31.2; 28.2 units on a scale — p=0.322
N/A N=1,418 Effects of Arousal and Stress in Anxiety
Healthy Volunteers
Primary: Go Correct Hits Followed by Button Press — 90.9; 91.6 Percentage of correct responses
N/A N=23 Stress and the Nervous System
Autonomic Nervous System · Baroreflex · Stress, Physiological
Primary: Cardiovagal Baroreflex Sensitivity (Modified Oxford Technique) — 17.75; 16.90; 14.42; 17.27 ms/mmHg
N/A N=58 Cranial Electrotherapy Stimulation and Acute Stress
Anxiety State
Primary: Change From Baseline in Heart Rate During Stressful Lethal Force Decision Making Task — 98.5; 111; 100.0; 114 bpm — p=.012
N/A N=72 Biological Response to Brief Psychological Challenge
Acute Inflammatory Response to Psychological Stress
Primary: Cell-free Mitochondrial DNA — 165.79; 405.56; 175.45; 164.45 Copies per uL — p=0.86
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
N/A N=87 Stress and Marijuana Cue-elicited Craving and Reactivity
Cannabis Use Disorders
Primary: Subjective Craving of Marijuana — 50.5; 52.3 Scores on a Scale
N/A N=120 College Student Stress: Transitions Over Time
Depressive Symptoms
Primary: Percentage of Eligible Participants Who Agreed to Participate in the Trial — 120 Participants
N/A N=38 Targeting Stress Reactivity in Schizophrenia: Integrated Coping Awareness Therapy
Schizophreniform Disorders
Primary: Change Over Time on the mDES - Positive — 0.35; 0.42; 0.62; 0.25 units on a scale
N/A N=119 Stress Response in Opioid Use Disorder
Opioid-use Disorder
Primary: Change in Negative Affect — 1.67; 1.25; 3.60 scores on a scale
Phase 4 N=226 Stress Neuroadaptation in Tobacco Dependence
Nicotine Dependence
Primary: Overall Stressor Reactivity — 25.1; 22.5; 32.3; 16.9 microvolts
N/A N=53 Stress in Inflammatory Bowel Disease
Inflammatory Bowel Diseases · Psychological
Primary: Retention Rate — 23; 25; 19; 22 Participants
N/A N=17 Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
Middle-aged Adults · Major Depressive Disorder
Primary: Nitric Oxide (NO)-Mediated Endothelium-dependent Dilation (EDD) — 70; 74 percentage — p=>0.05
Phase 2 N=65 Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects
Acute Stress Reaction
Primary: Acute Stress Measured by Tension — 3089.4; 3253.4 mm*min — p=0.1233
N/A N=91 Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)
Post Traumatic Stress Disorder
Primary: Mean Baseline Startle Magnitude During Fear Conditioning — 48.401; 56.595; 115.778; 57.684 microvolts
N/A N=102 Rapid Stress/Rest Single-Day Tc-99m Sestamibi Myocardial Single Photon Emission Computed Tomography
Coronary Artery Disease
Primary: Myocardial Perfusion SPECT Image Quality 12 Minutes — 1; 0; 8; 3 participants
N/A N=25 A Biomarker Stress Test for Detection of Early Osteoarthritis
Osteoarthritis
Primary: Change at 6 Months From Baseline in First Peak Knee Adduction Moment (KAM): (6 Month Value - Baseline) — -0.19 %Bw*Ht
Phase 4 N=84 Stress & Premenstrual Symptoms Study
PMDD · Stress · Mood
Primary: Acoustic Startle Response (ASR) Magnitude Based on Menstrual Cycle Phase — 54.2; 53.7; 56.4; 53.3 t score — p=0.139
Phase 3 N=80 Post Traumatic Stress Disorder (PTSD) Hyperarousal Symptoms Treated With Physiological Stress Management
Stress Disorders, Post-Traumatic
Primary: Change Scores for Criteria D Items on the CAPS Structured Clinical Interview — -1.20; -6.27 units on a scale — p=.27
Phase 2 N=109 Stress and Medication Effects on Cocaine Cue Reactivity
Cocaine Related Disorders
Primary: Cocaine Craving — 3.08; 4.36; 1.54; 3.13 units on a scale
Phase 2 N=121 Stress Management for Patients With Multiple Sclerosis
Multiple Sclerosis
Primary: No.of Gd+ Lesions From Week 8 to Week 24 — 46; 33; 5; 13 participants — p=0.04
Phase 2 N=66 Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects
Acute Stress Reaction
Primary: Acute Stress Measured by Tension — 3335.7; 3360.3 mm*min — p=0.7726
N/A N=50 Comparison of Two Behavioral Treatments for Stress Reduction
Stress
Primary: Brain Activity (fMRI) During the Body Scan Meditation — 74; 82 voxels
N/A N=323 Stress, Salt Excretion, and Nighttime Blood Pressure
Blood Pressure · Psychological Stress
Primary: Ratio of Awake-to-asleep Urinary Sodium Excretion Rate (Aim 1) — 1.4 Ratio of awake-to-asleep — p=0.0032
N/A N=10 Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG
Stress Induced Cardiomyopathy
Primary: Number of Participants Who Had an Abnormal Regional Uptake of I-123 mIBG at Baseline (Acute Phase) and the Number of Participants Who Had an Abnormal I-123 mIBG Uptake…
N/A N=151 Stress Management and Biomarkers of Risk in Cardiac Rehabilitation
Coronary Heart Disease
Primary: Absolute Composite Stress Score — 77.6; 67.5 Mean rank score
N/A N=93 Recovery After Stress Toolkit (RESET) Study
Post-Traumatic Stress Disorder in Children · Post-Traumatic Stress Disorder in Adolescence
Primary: Child PTSD Symptom Scale (CPSS) — 10.4; 14 Score on a scale
N/A N=50 Stress and CKD Among African Americans
Chronic Kidney Disease
Primary: Change in Subjective Units of Distress Scale (SUDS) Score — 2.92; 3.12 score on a scale
N/A N=269 Does Social Buffering Continue to be Effective Over the Peripubertal Period When Friends Share the Stressor Experience?
Adolescent Behavior · Social Stress
Primary: Cortisol AUCi — 0.0043; 0.0256; 0.0177; 0.022 (ug/dl)*minutes