Phase 3 N=137 Chlorhexidine vs. Iodine for Vaginal Preparation in Urogynecologic Procedures
Pelvic Organ Prolapse · Urinary Incontinence · Pelvic Floor Disorders
Primary: Rate of Urinary Tract Infection — 4; 7 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=30 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor
Pelvic Organ Prolapse · Menopause
Primary: Vaginal Wall Composition: Epithelium (Intention to Treat) — 413.9; 314.1 microns — p=0.21
Phase 2 N=75 Preoperative Levator Ani Muscle Injection and Pudendal Nerve Block for Pain Control After Vaginal Reconstructive Surgery
Pelvic Organ Prolapse · Surgery · Postoperative Pain
Primary: Primary Postoperative Pain Measured by the Numerical Rating Scale (NRS) — 3.0; 4.0; 3.75 score on a scale — p=0.39
N/A N=49 Vaginally Assisted Laparoscopic Hysteropexy Versus Vaginal Hysterectomy
Pelvic Organ Prolapse
Primary: Number of Participants With Recurrence of Pelvic Organ Prolapse — 0; 0 Participants
N/A N=32 Injection of Botox in the Perineal Muscles in Resistant Cases of Vaginal Spasm
Vaginismus
Primary: Success of Repeated Penetration of the Penis Through the Vaginal Introitus Into the Vagina Without or With Acceptable Pain — 28 participants
Phase 4 N=18 Prophylactic Antibiotics for Prevention of Wound Complications Following Vulvectomy
Wound Infection
Primary: Wound Complications — 3; 2 Participants
Phase 4 N=199 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen
Pelvic Organ Prolapse · Urogenital Prolapse · Vaginal Vault Prolapse
Primary: Surgical "Failure" Defined by (i) Anatomic Assessment of Prolapse, (ii) Presence of Bulge Symptoms, and/or (Iii) Retreatment of Prolapse — 18; 8 Participants
Phase 4 N=134 Tolerance of Chlorhexidine Gluconate Vaginal Cleansing Solution
Surgical Preparation of the Vagina
Primary: Number of Participants With Vaginal or Urinary Symptoms After Surgery, Assessed by Validated Questionnaire (Modified PRO-CTCAE) — 4; 11; 8; 25 Participants
Phase 4 N=64 Barbed Suture vs Smooth Suture for Vaginal Cuff Closure
Closure of Vaginal Cuff at Laparoscopic Hysterectomy
Primary: Vaginal Cuff Closure Time — 10.4; 9.6 minutes
N/A N=120 Vaginal Cuff Dehiscence and Thermal Injury During TLH
Vaginal Cuff Dehiscence · Thermal Injury
Primary: Degree of Thermal Injury at the Time of Laparoscopic Hysterectomy — 0.68; 0.63; 0.66; 0.70 mm
N/A N=70 Hysterectomy by Transabdominal Laparoscopy or NOTES
Uterine Diseases
Primary: Successful Removal of the Uterus Without Conversion to Another Technique — 35; 35 Participants — p=0.0221
Phase 4 N=58 Comparison of the Effects of Cervical Vasopressin Versus no Premedication on Blood Loss During Vaginal Hysterectomy: A Randomized, Placebo Controlled Trial
Blood Loss During Vaginal Hysterectomy
Primary: Intra-operative Blood Loss During Vaginal Hysterectomy
N/A N=300 Cervical Preparation Before Dilation and Evacuation
Abortion, Induced
Primary: Operative Time — 6.27; 6.28; 5.53 minutes
N/A N=50 Mifepristone Versus Laminaria Insertion for Cervical Preparation Prior to Surgical Abortion at 14-16 Weeks
Abortion
Primary: Time for Completion of Procedure — 8.0; 9.87 Minutes — p=0.05
Phase 3 N=640 Clinical Evaluation of Patient Preoperative Prep
Surgical Skin Preparation
Primary: Bacterial Reduction — 4.04; 4.01; 1.60 log10 cfu/cm^2
N/A N=37 Pelvic Floor Physical Therapy vs Standard Care in Transgender Women Undergoing Vaginoplasty for Gender Affirmation
Pelvic Floor Disorders
Primary: Patient Reported Ease of Dilation — 6.6; 7.4; 8.0 units on a scale
N/A N=236 Apical Support During Hysterectomy for Pelvic Organ Prolapse
Pelvic Organ Prolapse
Primary: Proportion of Patients Having Concurrent Apical Suspension Performed — 66 Participants
Phase 4 N=44 Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS)
Pain Management
Primary: Narcotic Use — 8; 6.75 MME
Phase 2 N=51 Efficacy and Safety Study of the Misoprostol Vaginal Priming Insert (MVPI) Prior to Hysteroscopy
Cervical Priming
Primary: Change in Diameter of the Internal Cervical os From Baseline (Pre-treatment) to Just Prior to the Hysteroscopy Procedure (Post-treatment). — 2.2; 2.3; 1.5 mm
N/A N=97 Laparoscopic Enclosed Morcellation; Electromechanic Morcellation vs Vaginal Removal
Myoma
Primary: Operation Time — 146.1; 124.6 seconds
N/A N=47 Radiofrequency and Hybrid Fractional Laser for Vaginal Rejuvenation
Vaginal Atrophy
Primary: Vulvovaginal Symptoms Questionnaire — 8; 7.88; 5.93; 5.93 score on a scale
N/A N=70 Surgical Study Comparing 2 Procedures for the Treatment of a Dropped Bladder
Prolapse
Primary: Change in the Stage of Prolapse of the Anterior Vaginal Wall Before and One Year After Surgery
Phase 4 N=107 Preoperative Gabapentin vs Placebo for Vaginal Prolapse Surgery
Pelvic Organ Prolapse · Perioperative/Postoperative Complications
Primary: Postoperative Opioid Use — 25; 20 MMEs
N/A N=54 Postoperative Virtual Clinical Encounters
Pelvic Organ Prolapse
Primary: Patient Satisfaction Via the Patient Satisfaction Questionnaire -18 — 80.7; 81.2 score on a scale
Phase 3 N=30 Vaginal Preparation With Chlorhexidine-alcohol vs. Povidine-iodine vs. Saline
Cesarean Section; Infection · Surgical Site Infection
Primary: Post-intervention Aerobic Bacterial Colony Counts — 2.959; 0.945; 5.104 Log (CFU/mL)
Phase 4 N=90 Preemptive Local Anesthesia in Vaginal Surgery
Pain, Postoperative
Primary: Visual Analogue Scale (VAS) Pain Score — 2.5; 4.4 points on a scale — p=.003
N/A N=32 Transcervical Balloon Compared to Osmotic Dilators Prior to Surgical Abortion
Abortion, Second Trimester
Primary: Procedure Time — 22.4; 22.6 minutes
N/A N=7 A Trial to Evaluate Natural Orifice Transvaginal Endoscopic Cholecystectomy With Laparoscopic Assistance
Gallbladder Disease
Primary: Procedure Completion — 7 participants
Phase 4 N=70 24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
Abortion, Second Trimester
Primary: Procedure Time — 9.5; 9.9 minutes
N/A N=183 Study of Uterine Prolapse Procedures - Randomized Trial
Uterovaginal Prolapse
Primary: Cumulative Failure — 78; 69; 9; 16 Participants