Phase 2 N=60 Transfusion Strategies in Pediatric Cardiothoracic Surgery
Congenital Heart Disease
Primary: Mean Arterial Lactate Level — 1.4; 1.4 mmol/L
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=22 The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants
Anemia of Prematurity
Primary: Change in Superior Mesenteric Artery Blood Flow Velocity From Pre-to-post Feed in the Anemic and the Transfused States — 2.02; 5.91; 7.66; 14.99 cm/sec — p=0.571
Phase 3 N=4,994 Standard Issue Transfusion Versus Fresher Red Blood Cell Use in Intensive Care- A Randomised Controlled Trial
Transfusion · Age of Blood
Primary: Mortality at Day 90 — 610; 594; 264; 259 participants
N/A N=722 Balancing Risk: Red Blood Cell Transfusion Strategies In Cardiac Surgery
Anemia
Primary: A Composite of In-hospital Postoperative Morbidity and Mortality — 59; 68 Participants
N/A N=254 Frozen Red Blood Cell Transfusions in Trauma Patients
Blood Loss · Anemia · Trauma
Primary: Tissue Oxygenation — 100.3; 98.2; 98.3 percentage of baseline
Phase 4 N=280 Immunomodulation Following Transfusion
Blood Component Transfusion
Primary: Number of Participants With Changes in the Production of Antibody to HLA Antigens — 2; 6; 2; 5 Participants
Phase 3 N=3,506 Myocardial Ischemia and Transfusion
Myocardial Infarction · Anemia
Primary: Number of Participants With All-cause Mortality or Nonfatal Myocardial Reinfarction — 255; 295 Participants
N/A N=14 Fresh Versus Old Red Blood Cells for Transfusion
Iron, Abnormal Blood Level · Other Abnormal Blood Chemistry
Primary: Measure of Non-transferrin-bound Iron — 0.16; 3.17 μM
Phase 2 N=43 Adverse Effects of Red Blood Cell Transfusions: A Unifying Hypothesis (Aim 3)
Cardiovascular Diseases
Primary: Brachial Artery Flow-mediated Dilation (FMD) After Fresh Red Blood Cells (RBCs) Transfusions vs. Storage-aged Red Blood Cells (saRBCs) Transfusions at Baseline — 4.87…
N/A N=25 Cord Blood Transfusion In Preterm Neonates (CB-TrIP)
Premature Infant Disease · Transfusion Related Complication · Fetal Hemoglobin
Primary: Median Percentage of HbF at 32 Weeks of Post Menstrual Age — 93.2; 90.8; 58.0; 69.0 percentage of total Hb — p=<0.0001
Phase 1 N=5 Transfusion of Biotinylated Red Blood Cells
Anemia
Primary: Number of Participants That Had bRBC Detectable at 70 Days Post-intervention — 5 participants
Phase 3 N=2,016 Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease
Anemia · Hematologic Diseases · Cardiovascular Diseases
Primary: Inability to Walk 10 Feet or Across a Room Without Human Assistance or Death — 351; 347 participants
Phase 3 N=26 Age of Blood in Sickle Cell Transfusion
Sickle Cell Disease
Primary: Proportion of Biochemically Old Red Cell Units — 0.71; 0.86 proportion biologically old units — p=0.051
Phase 3 N=199 Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Hemorrhagic Shock · Acute Blood Loss Anemia · Traumatic Brain Injury
Primary: Packed Red Blood Cells Equivalents Units Transfused (1 Whole Blood Unit Treated as 1 Packed Red Blood Cell Unit and 1 Fresh Frozen Plasma Unit) — 3.8; 5.7 units
Phase 4 N=20 Transfusion of Pathogen Reduced Cryoprecipitated Fibrinogen to Expedite Product Availability in Perioperative Bleeding
Hypofibrinogenemia · Bleeding
Primary: Total Number of RBCs Used Over Admission — 5.8; 6.7 RBC Units
Phase 4 N=100 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion
Anemia
Primary: Postoperative Wound Infection (Superficial or Deep) or Other Perioperative Infection — 12; 3 Participants — p=.0122
N/A N=1,824 Transfusion of Prematures Trial
Infant, Newborn, Diseases · Infant, Extremely Low Birth Weight · Infant, Small for Gestational Age
Primary: Death or Neurodevelopmental Impairment — 423; 422; 422; 425 Participants — p=0.93
Phase 3 N=110 Myocardial Ischemia and Transfusion Pilot
Myocardial Infarction · Unstable Angina · Coronary Artery Disease
Primary: Hemoglobin Concentration — 10.30; 9.03; 10.78; 8.98 g/dL — p=<0.001
Phase 2 N=17 Adverse Effects of RBC Transfusions: A Unifying Hypothesis
Healthy Volunteers
Primary: The Effects of Storage-related RBC Changes on Acetylcholine-stimulated (NO-mediated) Forearm Blood Flow. — 19.02; 18.42; 17.61; 22.89 mL / 100 mL / min
Phase 4 N=314 Effects of Microplegia on Transfusion Rates After Cardiac Surgery
Aortic Valve Disease · Mitral Valve Disease
Primary: Intraoperative and Postoperative Transfusions — 2.43; 2.97; 4.42; 3.50 units of blood per participant — p=0.354
N/A N=1,424 Transfusion Trigger After Operations in High Cardiac Risk Patients
Myocardial Infarction · Coronary Revascularization · Acute Renal Failure
Primary: A Composite Endpoint of All-cause Post-randomization Mortality, Myocardial Infarction (MI), Coronary Revascularization, Acute Renal Failure, or Post-randomization…
N/A N=200 Use of Pediatric Size Phlebotomy Tubes in Adult Critically Ill Patients to Reduce Red Blood Cell Transfusions
Anemia
Primary: Number of Participants Who Had Hemoglobin Less Than 7 g/dL or Red Blood Cell (RBC) Transfusion Order — 6; 11 Participants
Phase 1 N=22 Biotin-RBC Transfusion in SCD
Sickle Cell Disease
Primary: Percentage of Biotin Labeled RBCs — 97.3; 80; 21 percentage of biotin-labeled RBCs
Phase 2 N=56 Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
Subarachnoid Hemorrhage · Vasospasm
Primary: Change in Oxygen Delivery in Vulnerable Brain Regions — 3.7; 4.3 ml/100g/min — p=0.001
N/A N=150 IV Iron for the Anemia of Traumatic Critical Illness
Trauma · ICU Anemia
Primary: RBC Transfusion — 47; 55 participants
Phase 4 N=204 Reinfusion Drains vs Tranexamic Acid in Total Joint Arthroplasty
Total Joint Arthroplasty
Primary: Blood Transfusion — 5; 8; 1 participants
Phase 4 N=60 Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty
Revision Total Hip Arthroplasty (RTHA)
Primary: Number of Transfused Allogeneic Blood Units (in Digits). — 2.0; 0.0 units
Phase 2 N=104 Red Blood Cell (RBC) Survival Following Transfusion in Infants
Neonatal Anemia
Primary: Number of Discrete Biotinylated RBC Densities (up to 5 Discrete Densities) That Can be Accurately Measured by Flow Cytometry, i.e., Without Overlap. — 5; 5 flow…
Phase 4 N=107 Early Whole Blood in Patients Requiring Transfusion After Major Trauma
Trauma/Injury Problem
Primary: Units of Blood Products Required During the First 24 Hours After Emergency Department Admission — 12; 13 units of blood
N/A N=45 A Clinical Study to Investigate if Transfusion of Patients Own Shed Blood Improves the Immunological Status in Comparison to Transfusion of Donor Blood ("Bank Blood")
Arthroplasty, Replacement, Knee · Blood Transfusion, Autologous · Blood Transfusion
Primary: Frequency of Natural Killer Cells as Measured With Flow Cytometry. — 2.98; 2.26 total number of cells * 10^5/mL