Clinical Trial Search

Primary: Hamilton Depression Scale — 10.84; 12.45; 15.81 units on a scale

Primary: Hamilton Depression Rating Scale: Baseline — 20.93; 19.38 units on a scale

Primary: Inventory of Depressive Symptomatology- Clinician Rated (IDS-C) Scale — 22.7; 9.5 percentage of improved participants

Primary: Change in Hamilton Depression Scale — 17; 17.5; 20.7; 11.4 units on a scale

Primary: Change in Hamilton Depression Rating Scale (HAM-D) Scores — -13.0; -11.0; -6.8 Change in HAM-D score

Primary: Change From Baseline to Week 8 in HAMD-17 (Hamilton Depression Scale -17 Items) Total Score — 19.2; 8.1 score on a scale — p=<0.0001

Primary: Hamilton Depression Rating Scale — 16.46; 21.37; 16.35; 20.70 score on a scale

Primary: Change From Baseline in the Beck Depression Inventory-Version 1A (BDI-IA) Total Score at Week 12 — -4; -5.9 Score on scale — p=0.0103

Primary: Change From Baseline in Hamilton Depression Rating Scale (HAMD) — 48.1; 35.5 score on a scale

Primary: Change From Baseline in Unified Parkinson's Disease Rating Scale (UPDRS) Part I (Mentation, Behaviour and Mood) — 2; 2 Points on a scale

Primary: Number of Participants Reporting Serious Adverse Events or Other Adverse Events Leading Either to Discontinuation or to Death — 13 participants

Primary: Change in the Combined Scores (Sum) of Parts I, II, and III of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (M (MDS-UPDRS) From Baseline to…

Primary: Composite Antidepressant Score Scale (CAD) — 29; 25; 9; 20 Participants

Primary: Geriatric Depression Scale (GDS) Score — 5.11; 5.03; 4.59; 4.64 units on a scale

Primary: Montgomery Asberg Depression Rating Scale (MADRS) — 22.629; 26.102; 29.455 Score on a scale — p=.018

Primary: Depressive Symptom Severity as Measured by the Patient Health Questionnaire (PHQ-9) Depression Scale Results at 6 Months Follow up — 14.31; 14.54; 8.09; 7.53 score on a…

Primary: TST — 5.7; 6.0 hours

Primary: Dimensional Anhedonia Rating Scale (DARS) Score — 15.75; 33.08 score on a scale

Primary: Percentage of Participants With Adverse Events, Adverse Drug Reactions, and Serious Adverse Events — 21.7; 19.2; 2.5 percentage of participants

Primary: Hamilton Rating Scale for Depression (24 Item) — 10.94 Units on a Scale

Primary: Change in the Epworth Sleepiness Scale (ESS) Scores Comparing the Bright Light Exposure With Dim-red Light Exposure. — 4.46; 1.77 score — p=0.0211

Primary: The Number of Participants Who Fail to Complete the 12-week Study on Study Drug. — 7; 0 Participants

Primary: Clinical Global Impression of Change-Clinician Rated Score (CGIC-C) — 3; 6; 1; 2 Participants

Primary: Modfied Alzheimer's Disease Cooperative Study- Clinical Global Impression of Change (mADCS-CGIC) — 1; 0; 5; 2 participants — p=0.98

Primary: Selective Reminding Test (SRT) Total Recall — 45.6; 46.6 Words

Primary: Association Between Basal Ganglia Beta Power and Effort Level (Beta Coefficient) — -0.175 beta coefficient — p=0.007

Primary: Change in Hamilton Rating Scale for Depression (HAM-D) From Baseline to 6 Months — -1.4; 2.0 units on a scale — p=<0.05

Primary: Most Commonly Reported Past Barrier to Mental Health Services: "Anyone in my Situation Would be Struggling" — 74.8 percentage of total respondents

Primary: Change From Baseline to the End of Maintenance Period in the Score of the Hamilton Depression Scale (HAM-D) — -4.79; -3.68 units on a scale — p==0.1286

Primary: Symptoms of Depression in Congestive Heart Failure Patients With Clinical Depression After Treatment With Sertraline or Placebo — -7.1; -6.8 HDRS Change Score — p=0.89