Phase 3 N=13 Vitamin B6 Effects for Women Taking Birth Control Pills
Vitamin B6 Deficiency
Primary: Total Remethylation of Homocysteine — 6.07; 5.63 micromol/(kg x hr) — p=0.20
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=34 Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer
Breast Cancer · Drug/Agent Toxicity by Tissue/Organ · Endometrial Cancer
Primary: Number of Participants With Palmar-plantar Erythrodysesthesia (PPE) — 2; 3; 3; 3 participants — p=<0.05
Phase 3 N=319 A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients
Cancer
Primary: Neurotoxicity Assessment at Baseline — 8.5; 7.3; 5.23; 4.58 units on a scale
N/A N=132 Impact of Vitamin B12 Replacement on Epogen Dosing and Improvement of Quality of Life in Hemodialysis Patients
Vitamin B12 Deficiency
Primary: Change in Amount of Epogen Required — -16,572 unit/ml
N/A N=30 Natural Versus Synthetic Vitamin B Complexes in Human
Healthy · Thiamine and Niacin Deficiency States · Pyridoxine Deficiency
Primary: Serum Thiamine — 50.21; 48.33; 51.21; 50.60 "µg/L"
Phase 3 N=389 Study of Pyridoxine for Hand-Foot Syndrome
Hand-foot Syndrome
Primary: Cumulative Dose of Capecitabine Until the Development of Grade 2 or Higher Hand-foot Syndrome — 70000; 70000 miligram per square meter
Phase 4 N=160 Vitamin Deficiency in Immigrants, a Treatment Study
Vitamin D Deficiency
Primary: Serum-vitamin D — 19.7; 34.4; 38.7; 58.7 25(OH)D, nmol/L — p=0.001
Phase 2 N=23 The Effect of Riboflavin on Moderate to Severe Plaque Type Psoriasis
Psoriasis
Primary: Subjects Achieving 50% or Greater Psoriasis Area and Severity Index (PASI) Reduction — 2; 2 Participants
N/A N=21 Evaluation of Holotranscobalamin as an Indicator of Vitamin B12 Absorption
Disorder of Vitamin B12
Primary: Change in Holo-transcobalamin — 124 pmol/L
N/A N=206 Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans
Thiamine Deficiency · Thiamine Deficiency; Sequelae
Primary: Percentage of Participants With Thiamine Deficiency (Low Plasma Thiamine) Out of Total Number of Enrolled Veterans With Plasma Thiamine Results — 49 Participants
Phase 3 N=137 Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer
Breast Cancer · Drug/Agent Toxicity by Tissue/Organ · Unspecified Adult Solid Tumor, Protocol Specific
Primary: To Determine Whether the Prophylactic Use of a Topical Urea/Lactic Acid Cream Can Decrease the Incidence/Severity of Capecitabine-caused Palmar-plantar…
N/A N=41 Vitamin B12 for Aromatase Inhibitors Musculoskeletal Symptoms
Relief of Joint Pain
Primary: Percentage Change in Average Joint Pain in Women With Aromatase Inhibitor-associated Musculoskeletal Symptoms (AIMSS) Compared to Baseline as Measured by the Brief Pain…
N/A N=90 Vitamin D Replacement After Kidney Transplant
Kidney Transplantation · Vitamin D Deficiency
Primary: Compare Efficacy and Safety of Two Vitamin D Supplements of These Doses in Normalizing Vitamin D Concentrations. — 8; 29 ng/ml
N/A N=366 Randomized Trial of Vitamin B12 in Pregnant Indian Women
Pregnancy
Primary: Changes in Maternal Serum B12 Concentration From 1st to 3rd Trimester — 3.0; -37.6 pmol/L
N/A N=125 Autoantibodies to Gastric Parietal Cells in Rheumatoid Arthritis Patients
Vitamin B12 Deficiency
Primary: Prevalence of Vitamin B12 Deficiency — 3; 6; 4 participants
Phase 4 N=140 Effectiveness of Vitamin Supplementation in Treating People With Residual Symptoms of Schizophrenia
Schizophrenia
Primary: Positive and Negative Syndrome Scale (PANSS) — -.21; -.22 units on a scale
Phase 4 N=120 High Dose Vitamin B1 to Reduce Abusive Alcohol Use
Alcoholism
Primary: Change in Average Daily Alcohol Consumption — -3.4; -3.0 alcoholic drinks per day
Phase 3 N=402 Sub-clinical Inflammation and Iron Supplementation
Anemia
Primary: Haemoglobin Level — 88.3; 89.2; 88.4; 89.6 g/L — p=<0.05
N/A N=14 Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome
Hyperinsulinism-Hyperammonemia Syndrome
Primary: Tolerability of Vitamin E Based on Responses to a Subject/Parent-reported Symptom Questionnaire After Vitamin E Supplementation Compared to Baseline — 2 Participants
N/A N=28 Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes
Diabetes Type 2
Primary: Diff AUC SS0.5 Hyperglycemic — 0.74; 0.96 Pa*hr
N/A N=96 Impact of Vitamin D Repletion in Hemodialysis Patients
Vitamin D Deficiency · End-stage Renal Disease
Primary: Change in 25OH-Vitamin D Level — 15.8; 40.9 ng/dL
Phase 2 N=20 A Trial of Vitamin B12 in Septic Shock
Septic Shock
Primary: Feasibility of Clinical and Protocol Completion — 10; 10 Participants
Phase 3 N=265 Vitamin D Status of Pregnant Women and Their Children in Eau Claire, South Carolina
Vitamin D Deficiency · Pregnancy
Primary: 25-hydroxyvitamin D at Visit 7 — 36.7; 39.8 ng/mL
N/A N=10 The Brain, Neurological Features and Neuropsychological Functioning in Adults With Phenylketonuria: A Pilot Study
Phenylketonuria
Primary: Phenylalanine Level in the Brain as Determined by MR Spectroscopy and in Blood — 130; 137; 961 umol/L
N/A N=37 Efficacy of Vitamin D Supplementation in Bariatric Surgery Patients
Obesity · Vitamin D Deficiency
Primary: Vitamin D Concentrations, Pre Operative and Post Bariatric Surgery Following 12 Weeks of Vitamin D Supplementation — 19.1; 27.2 ng/mL — p=< 0.001
N/A N=20 Vitamin D Supplementation in Kidney Disease
Renal Dialysis · Vitamin D Deficiency
Primary: Change in Hip Flexor Strength — 20.34; 6.83 percent change
Phase 4 N=7 The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
Vitamin B1 Deficiency · Thiamine Deficiency
Primary: Maximum Concentration (Cmax) of Thiamine in Plasma Between the Combination Arm(s) and Single Agent Arm — 15; 32 nM
N/A N=47 GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures
Parkinson's Disease
Primary: Unified Parkinson's Disease Rating Scale (UPDRS) Change — 21.25; 22.4; 20.8; 22.31 units on a scale
N/A N=20 Suspected Deficient Activation of Vitamin D in Patients With Secondary Hyperparathyroidism
Secondary Hyperparathyroidism
Primary: The Level of Activated Vitamin D (1,25-dihydroxyvitamin D) After Parathyroid Hormone Infusion at Baseline, 4 and 8 Hours — 40.6; 46.2; 39.8; 58.8 pg/ml — p=0.1
N/A N=19 Ultraviolet Light And Vitamin D In Subjects With Fat Malabsorption Or After Gastric Bypass Surgery
Vitamin D Deficiency · Gastrointestinal Diseases
Primary: # of Pts w/ Enhanced Vitamin D Status — 3; 3 Participants