N/A N=36 Vitamin C Supplementation Intervention
Heart Failure
Primary: Serum Vitamin C Level at Baseline — 13372; 16079; 13111 ng/mL
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=28 Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes
Diabetes Type 2
Primary: Diff AUC SS0.5 Hyperglycemic — 0.74; 0.96 Pa*hr
Phase 3 N=125 Vitamin C and Septic Shock
Septic Shock · Sepsis
Primary: Number of Participants With ICU Mortality — 20; 14 Participants
Phase 3 N=252 Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
Pulmonary Function; Newborn, Abnormal · Infant Wheeze · In-utero Nicotine
Primary: Forced Expiratory Flow at 75% of Expired Volume (FEF75) — 188.7; 200.7 ml/s — p=0.19
Phase 4 N=160 Vitamin Deficiency in Immigrants, a Treatment Study
Vitamin D Deficiency
Primary: Serum-vitamin D — 19.7; 34.4; 38.7; 58.7 25(OH)D, nmol/L — p=0.001
N/A N=68 Intravenous Vitamin C in the Treatment of Viral Infection, Especially in the Treatment of Shingles
Virus Diseases · Herpes Zoster
Primary: Change of Pain Measured by VAS — 5.8; 2.2; 0.6; 1.2 pain intensity
Phase 4 N=57 Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients
Reperfusion Injury
Primary: Mortality — 0; 0 participants
N/A N=99 hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects
Healthy Subjects · Vitamin D Deficiency
Primary: hCAP18 Levels — 762; 639 ng/ml
N/A N=134 Does Vitamin C Reduce Finger Stiffness After Distal Radius Fractures?
Finger Stiffness · Distal Radius Fracture
Primary: Distance to Palmar Crease Index Through Small Finger — 6.7; 7.1; 2.3; 2.0 Centimeters — p=0.63
Phase 2 N=167 Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury
Acute Lung Injury · Sepsis
Primary: Modified Change in Sequential Organ Failure Assessment (mSOFA) Score — -2.96; -3.20 score on a scale
Phase 3 N=265 Vitamin D Status of Pregnant Women and Their Children in Eau Claire, South Carolina
Vitamin D Deficiency · Pregnancy
Primary: 25-hydroxyvitamin D at Visit 7 — 36.7; 39.8 ng/mL
Phase 2 N=20 Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation
COVID-19 · Hypoxia
Primary: Number of Participants With Adverse Events Related to High Dose Intravenous Vitamin C (HDIVC) — 0; 0 Participants
Phase 2 N=20 Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis
Alcoholic Hepatitis · Sepsis
Primary: Change in Model for End Stage Liver Disease (MELD) Score — -0.13; -2.9; -2.3; -2.4 score on a scale
N/A N=66 "Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Complex Regional Pain Syndrome I of Lower Limb
Primary: Number of Participants Operated for Complex Regional Pain Syndrome Who Had Transposition of Anterior Tibial Tuberosity — 1; 0; 2 participants
Phase 2 N=55 Therapeutic Use of Intravenous Vitamin C in Allogeneic Stem Cell Transplant Recipients
Lymphoid Leukemia · Myeloid Leukemia · Monocytic Leukemia
Primary: The Proportion of Patients That Experience Non-relapse Mortality (NRM) — 5 Participants
N/A N=36 The Impact of Qualia Vitamin C+ on Blood Vitamin C Levels
Vitamin C Deficiency
Primary: To Assess Between-group Differences in the Change in Blood Vitamin C Levels From Baseline to Day 28 — 0.365; 0.133 mg/dL — p=0.03
N/A N=96 Vitamin D Repletion in Coronary Artery Disease
Vitamin D Deficiency · Coronary Artery Disease · Endothelial Dysfunction
Primary: Endothelial Function — 0.13; -0.04 reactive hypermia index
Phase 3 N=402 Sub-clinical Inflammation and Iron Supplementation
Anemia
Primary: Haemoglobin Level — 88.3; 89.2; 88.4; 89.6 g/L — p=<0.05
Phase 2 N=24 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis
Sepsis · Septic Shock · Hypotension
Primary: Number of Patients Who Experienced Ascorbic Acid Infusion Related Arterial Hypotension, Vomiting, or Tachycardia in Septic Patients — 0; 0; 0 participants
Phase 2 N=62 Vitamin D for Sickle-cell Respiratory Complications
Sickle Cell Disease · Vitamin D Deficiency · Acute Chest Syndrome
Primary: Mean Annual Rate of Respiratory Events — 3.91; 4.34; 3.34; 4.28 events per year
Phase 2 N=20 Vitamin C in Atrial Fibrillation Ablation
Atrial Fibrillation Ablation
Primary: Change in Creatinine Levels — -0.1; -0.1 mg/dL
N/A N=90 Vitamin D Replacement After Kidney Transplant
Kidney Transplantation · Vitamin D Deficiency
Primary: Compare Efficacy and Safety of Two Vitamin D Supplements of These Doses in Normalizing Vitamin D Concentrations. — 8; 29 ng/ml
Phase 2 N=4 A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations
Myelodysplastic Syndromes
Primary: Number of Patients Who Experienced a Dose Limiting Toxicity (DLT) — 0; 0; 0 Participants
Phase 1 N=19 Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents
Obesity · Endothelial Dysfunction · Vitamin D Deficiency
Primary: Flow Mediated Dilatation (FMD) — 9.5; 10.4 percentage increase in BAD — p=0.59
Phase 2 N=120 Vitamin C & Thiamine to Treat Sepsis and Septic Shock
Sepsis · Septic Shock
Primary: Mortality Rates — 12; 7 Participants — p=0.344
Phase 2 N=46 High Dose Vitamin D for Sickle Cell Disease
Sickle Cell Disease
Primary: 25 (OH)D in Nmol/L Between Baseline and 6 Months — 55.2; 50.4 nmol/L — p=0.0507
N/A N=35 Bioequivalence Study on Vitamin C in Healthy Adults
Dietary Exposure
Primary: Mean Plasma L-ascorbic Acid as Total Area Under the Curve [AUC(0-24 Hours)] — 1114.66; 1149.09 μmol*min/L
Phase 3 N=33 Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures
Atrial Fibrillation
Primary: Incidence of Postoperative Atrial Fibrillation — 5; 4; 5 participants
Phase 4 N=10 The Effect of High Dose Vitamin C on the Liver Function in Chronic Hepatitis Patients
Chronic Hepatitis · Chronic Hepatitis C · Chronic Alcoholic Hepatitis
Primary: The Change in Serum Alanine Aminotransferase Level From Baseline to 12 Weeks — 77.5; 105.5 IU/L
Phase 2 N=58 Daily Vitamin D for Sickle-cell Respiratory Complications
Sickle Cell Disease · Anemia, Sickle Cell · Anemia, Hemolytic, Congenital
Primary: Annual Rate of Respiratory Events — 3.3; 3.3; 3.4; 3.2 Respiratory events per year