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HIFU associated with superior erectile function and urinary continence compared to RARP in localized prostate cancerHIFU treatment shows better sexual and urinary function in prostate cancer

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Key Takeaway
Note that HIFU is associated with better erectile function and urinary continence than RARP in localized prostate cancer.

This meta-analysis evaluated the comparative outcomes of high-intensity focused ultrasound (HIFU) versus robot-assisted radical prostatectomy (RARP) in 2123 patients with localized prostate cancer. The study focused on functional outcomes, including erectile function, urinary continence, and symptom scores.

Findings indicated that the HIFU group achieved significantly higher IIEF-5 scores at 6 months (3.41; 95% CI [1.88-4.94]), 12 months (3.75; 95% CI [3.00-4.49]), and 24 months (2.72; 95% CI [0.59-4.85]). Additionally, urinary continence (pad-free rates) favored HIFU with an OR of 0.40 (95% CI [0.27-0.59]). No significant differences were found between the two groups regarding International Prostate Symptom Score (IPSS) or salvage therapy rates.

The authors noted that long-term oncologic outcomes remain to be confirmed. While HIFU shows promise for preserving functional quality of life, the lack of long-term oncologic data necessitates caution when choosing between these modalities for localized prostate cancer. Clinical application should consider the balance between immediate functional benefits and long-term cancer control.

How this fits prior evidence

This meta-analysis addresses a gap in comparing functional outcomes between HIFU and RARP for localized prostate cancer. While prior coverage has discussed surgical techniques like tele-robot-assisted prostatectomy and pharmacological options like Lu-PSMA-617 or denosumab, this study specifically provides evidence on the impact of HIFU on erectile function and urinary continence compared to RARP.

When men face a diagnosis of localized prostate cancer, they often worry about how treatment will affect their quality of life. Specifically, many worry about losing the ability to control their bladder or maintaining sexual function. A large review of data involving over 2,000 patients compared two common ways to treat the cancer: high-intensity focused ultrasound (HIFU) and robot-assisted radical prostatectomy (RARP).

The findings show that men who received the ultrasound treatment had higher scores for erectile function at the 6, 12, and 24-month marks compared to those who had surgery. Additionally, the ultrasound group showed better rates of urinary continence, meaning they were more likely to be free of pads. Both groups reported similar levels of general prostate symptoms and had similar rates of needing further treatment later on.

While these results are encouraging for patients concerned about side effects, it is important to note that the study did not provide data on long-term cancer outcomes. Because these results come from a meta-analysis of other studies, the long-term success of the cancer treatment itself is still being confirmed. Patients should talk to their doctor to decide which path fits their specific health needs.

What this means for you:
HIFU may offer better sexual and bladder control than surgery for some men with localized prostate cancer.

Common questions

How does HIFU compare to surgery for bladder control?

Patients who received high-intensity focused ultrasound (HIFU) showed better rates of urinary continence, meaning they were more likely to be pad-free, compared to those who had robot-assisted surgery. These results were consistent at the start of treatment and through the 12-month follow-up period.

Does HIFU help with sexual function after prostate cancer treatment?

Yes, the data shows that men who received HIFU had higher scores for erectile function at 6, 12, and 24 months compared to those who had surgery. These scores were consistently higher in the ultrasound group across all three check-in points.

Are there differences in the need for more treatment later?

There was no significant difference between the two groups regarding salvage therapy rates. This means both the ultrasound and the surgery groups had similar rates of needing additional treatment later on.

Study Details

Study typeMeta analysis
Sample sizen = 2,123
EvidenceLevel 1
Follow-up6.0 mo
PublishedSep 2026
View Original Abstract ↓
BACKGROUND: This study aimed to compare functional and oncologic outcomes between high-intensity focused ultrasound (HIFU) and robot-assisted radical prostatectomy (RARP) for patients with localized prostate cancer (LPCa). METHODS: Four databases (Embase, PubMed, Cochrane Library, Web of Science) were systematically searched from inception to December 2025. The review followed PRISMA 2020 and AMSTAR 2 guidelines. Pooled effect estimates were calculated using Stata 17. Random-effects models were applied when I was 50 % or higher or the P value was lower than 0.10. RESULTS: Five cohort studies (n = 2123) were included. In this review, HIFU was associated with significantly higher International Index of Etile Function (IIEF)-5 scores at 6 months (effect, 3.41; 95 % confidence interval [Cl], 1.88-4.94; P < 0.05), 12 months (effect, 3.75; 95% Cl 3.00-4.49; P < 0.05), and 24 months (effect, 2.72; 95% Cl 0.59-4.85; P < 0.05). Urinary continence overy also favored HIFU (odds ratio [OR], 0.40; 95% Cl 0.27-0.59; P < 0.05) for pad-free rates at baseline and at 6 and 12 months (all P < 0.05). No significant differences were observed in International Prostate Symptom Score (IPSS) or salvage therapy rates. CONCLUSION: For patients with localized prostate cancer, HIFU offers better etile function and urinary continence overy than RARP, with comparable complication and salvage therapy rates. Long-term oncologic outcomes remain to be confirmed.
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