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Botulinum toxin type A as an add-on improves scar appearance scores in multimodal managementBotox May Improve Scar Appearance, Review Suggests

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Key Takeaway
Note that BoNT-A may offer adjunctive benefit for scar appearance, but evidence is low-certainty and exploratory.

This meta-analysis evaluates the efficacy of botulinum toxin type A (BoNT-A) when used as an add-on in combination or sequential protocols for scar management compared to standard care alone. The analysis focused on outcomes measured by the Vancouver Scar Scale (VSS) and the Stony Brook Scar Evaluation Scale (SBSES).

The synthesis indicates that BoNT-A addition is associated with improved scar appearance, specifically showing a mean difference of -1.80 on the VSS and 1.46 on the SBSES. These results suggest that BoNT-A may provide an adjunctive benefit for improving aesthetic outcomes and potentially mitigating local mechanical tension.

Authors note that the evidence is of low certainty due to highly heterogeneous treatment paradigms across included studies. The findings are described as suggestive rather than confirmatory. Clinical application should be approached with caution, tailored to individual patient needs, and interpreted as exploratory data given the current limitations in study consistency.

How this fits prior evidence

This finding addresses a gap in the management of physical markers of injury by evaluating BoNT-A for scar improvement. While other reported uses of botulinum toxin type A include improving nasal symptoms in allergic rhinitis (SMD -2.07), reducing masseter prominence, and reducing axillary sweat, this meta-analysis specifically addresses the role of BoNT-A as an adjunctive therapy for scar appearance.

A new analysis of existing studies suggests that adding botulinum toxin type A (BoNT-A), commonly known as Botox, to standard scar management may improve scar appearance. The review looked at patients who received BoNT-A as an add-on treatment alongside other scar therapies, compared to standard care alone.

The findings showed that scars treated with BoNT-A scored better on two common rating scales: the Vancouver Scar Scale (VSS) and the Stony Brook Scar Evaluation Scale (SBSES). On the VSS, the improvement was about 1.80 points, and on the SBSES, about 1.46 points. These results suggest a potential benefit for scar appearance.

However, the evidence is considered low-certainty. The studies included used different treatment approaches, making it hard to draw firm conclusions. The findings are suggestive rather than confirmatory, and experts say they are strictly exploratory.

No safety information was reported in the analysis, so it is not clear if there were any side effects. The review highlights that BoNT-A may help by reducing local mechanical tension on scars, but clinical use should be cautious and tailored to each patient. More research is needed to confirm these results.

What this means for you:
Adding Botox to scar care may improve appearance, but evidence is low-certainty.

Common questions

Does Botox help scars look better?

A review of studies suggests that adding Botox to standard scar care may improve scar appearance on two rating scales. However, the evidence is low-certainty, so results are not confirmed.

How much does Botox improve scar appearance?

Scars treated with Botox scored about 1.80 points better on the Vancouver Scar Scale and 1.46 points better on the Stony Brook Scar Evaluation Scale compared to standard care alone.

Is Botox safe for scar treatment?

The review did not report any safety information, such as side effects or complications. More research is needed to understand the safety of Botox for scar management.

Who might benefit from Botox for scars?

The review included patients with scars managed with multimodal strategies. Botox was used as an add-on treatment. The findings are exploratory, so it is not clear who would benefit most.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
BackgroundBotulinum toxin type A (BoNT-A) has been increasingly incorporated into multimodal scar management strategies as an adjunctive treatment. However, the additive benefits of BoNT-A when used in combination or sequential therapeutic approaches remain unclear due to limited and heterogeneous evidence.MethodsA systematic review and meta-analysis of randomized controlled trials was conducted in accordance with the PRISMA guidelines. PubMed, Embase, and the Cochrane Library were searched to identify studies evaluating BoNT-A as an add-on intervention in combination or sequential scar management strategies. Eligible studies compared BoNT-A plus standard scar management with control interventions alone. Primary outcomes included validated scar assessment scores, namely the Vancouver Scar Scale (VSS) and the Stony Brook Scar Evaluation Scale (SBSES). Pooled analyses were performed using mean differences (MDs) with 95% confidence intervals (CIs).ResultsSix randomized controlled trials (RCTs) were included. The pooled analysis suggested that BoNT-A add-on therapy significantly improved scar appearance, with a Mean Difference (MD) of −1.80 for the VSS score and 1.46 for the SBSES score. However, this represents low-certainty evidence.ConclusionCurrent low-certainty evidence suggests that BoNT-A may provide a potential adjunctive benefit for improving scar appearance, particularly in mitigating local mechanical tension. However, because these pooled estimates reflect a composite of heterogeneous treatment paradigms, the findings are suggestive rather than confirmatory and strictly exploratory. Clinical application should remain cautious and individualized, pending further high-quality, standardized RCTs.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD420261354679, PROSPERO CRD420261354679.
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