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Home › Medications › botulinum toxin type A

botulinum toxin type A

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of botulinum toxin type A

146 trials tracked of botulinum toxin type A: 93 in phase 3 or 4 and 33 with published results. The most-cited published study has 220 citations.

146Trials tracked
93Phase 3 & 4
0Recruiting
33With published results
Phase distribution
Phase 4 28 Phase 3 65 Phase 2 34 Phase 1 2 Other / NA 17
  1. Phase 3 Anticholinergic vs. Botox Comparison Study Completed · 220 cited
  2. Phase 4 A Long-term Efficacy, Safety, and Tolerability Study of BOTOX® in Patients With Chronic Migraine Completed · 192 cited
  3. Phase 3 Efficacy and Safety Dose Titration Study of Botulinum Toxin Type A to Treat Spasticity in the Leg and Arm Completed · 122 cited
  4. Phase 3 Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions Completed · 119 cited
  5. Phase 4 Efficacy and Safety Study of BOTOX® Compared to Topiramate for the Prevention of Chronic Migraine in Adults Completed · 108 cited
  6. Phase 3 Dysport® Adult Lower Limb Spasticity Study Completed · 96 cited
Show 44 more trials
  1. Phase 3 Dysport® Adult Lower Limb Spasticity Follow-on Study Completed · 96 cited
  2. Phase 4 Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression Completed · 48 cited
  3. Phase 4 The Treatment of Glabellar Frown Lines Completed · 46 cited
  4. Phase 3 Study Comparing Short Term Efficacy of Dysport and Dysport NG to Placebo, and to Assess Efficacy and Safety of Dysport NG of Subjects With Cervical Dystonia Completed · 44 cited
  5. Phase 3 Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia Completed · 41 cited
  6. Phase 3 Efficacy And Safety Of Dysport In The Treatment Of Upper Limb Spasticity In Children Completed · 37 cited
  7. Phase 3 Study to Assess the Efficacy and Safety of Dysport® in the Treatment of Chronic Plantar Fasciitis Completed · 33 cited
  8. Phase 3 Safety and Efficacy of NT 201 (IncobotulinumtoxinA [Xeomin]) in the Treatment of Glabellar Frown Lines Completed · 30 cited
  9. Phase 3 Safety and Efficacy Study of OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Neurogenic Detrusor Overactivity (NDO) in Non-Catheterizing Patients With Multiple Sclerosis (MS) Completed · 25 cited
  10. Phase 3 MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity Completed · 24 cited
  11. Phase 4 Functional Effects of Botox on the Brain Using MRS and fMRI Completed · 21 cited
  12. Phase 3 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy Completed · 19 cited
  13. Phase 4 OnabotulinumtoxinA (BOTOX®) Treatment for Urinary Incontinence in Patients With Overactive Bladder Completed · 17 cited
  14. Phase 3 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Leg(s) in Cerebral Palsy Completed · 17 cited
  15. Phase 3 A Phase III Study to Evaluate the Efficacy and Safety of GSK1358820 in Subjects With Post-stroke Upper Limb Spasticity Completed · 15 cited
  16. Phase 4 Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC) Completed · 11 cited
  17. Phase 3 Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia. Completed · 10 cited
  18. Phase 3 Long-term Open-label Study of Botulinumtoxin Type A to Treat Spasticity of Leg(s) or Leg(s) and Arm in Cerebral Palsy Completed · 8 cited
  19. Phase 3 Botulinum Toxin Versus Placebo Injections to Temporalis and Masseter Muscles Completed · 8 cited
  20. Phase 3 Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study II Completed · 6 cited
  21. Phase 3 Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study I Completed · 6 cited
  22. Phase 3 Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study III (BLESSIII) Completed · 6 cited
  23. Phase 3 Efficacy and Safety of Clostridium Botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines Completed · 5 cited
  24. Phase 3 Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines Completed · 5 cited
  25. Phase 3 Dysport® Adult Upper Limb Spasticity Extension Study Completed · 4 cited
  26. Phase 3 Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia Completed · 3 cited
  27. Phase 4 Evaluation of an Alternative Injection Paradigm for OnabotulinumtoxinA (BOTOX®) in the Treatment of Overactive Bladder in Patients With Urinary Incontinence Completed · 1 cited
  28. Phase 4 A Safety and Efficacy Study of BOTOX® in Korean Adults With Chronic Migraine Completed
  29. Phase 4 Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study) Completed
  30. Phase 4 Botulinum Toxin Type A Injection After Topical Anesthesia Versus Petrolatum Ointment Completed
  31. Phase 4 Quality of Life and Self-esteem After Botox® Injections in Depressed and Non-depressed Patients Completed
  32. Phase 4 Study of the Safety and Efficacy of Botox in Bruxism Completed
  33. Phase 4 (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist Completed
  34. Phase 4 Calcitonin Gene-related Peptide Levels in Chronic Migraine Completed
  35. Phase 4 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds Completed
  36. Phase 4 Comparison of Efficacy and Safety of Two Different Types of Botulinum Toxin Type A in Moderate to Severe Cervical Dystonia Completed
  37. Phase 4 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed
  38. Phase 4 Patient Satisfaction With Treatment of BOTOX® Cosmetic for the Temporary Correction of Moderate to Severe Glabellar Lines Completed
  39. Phase 4 Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines Completed
  40. Phase 4 Botox for Cervical Dystonia Following EMG Mapping Completed
  41. Phase 4 Comparison of Two Commercial Preparations of Botulinum Toxin Type A Completed
  42. Phase 4 Duration of Benefit for OnabotulinumtoxinA in Treatment of Chronic Migraine Completed
  43. Phase 4 Patient Satisfaction Study of BOTOX® Cosmetic in the Treatment of Moderate to Severe Frown Lines Completed
  44. Phase 4 Use of a Treatment Benefit Questionnaire in Patients With Chronic Migraine Treated With OnabotulinumtoxinA (BOTOX®) Completed

Showing the 50 most-cited and recently-updated of 146 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Botulinum toxin type A as an add-on improves scar appearance scores in multimodal management
Anesthesiology & Pain Medicine Meta-analysis
Botulinum toxin type A as an add-on improves scar appearance scores in multimodal management Botox May Improve Scar Appearance, Review Suggests
This meta-analysis evaluates the addition of botulinum toxin type A to standard protocols for managing scars. The analysis found improved ou…
Adding Botox to standard scar care may improve how scars look, but the evidence is low-certainty.
Frontiers Jun 11, 2026
Botulinum toxin type A improves nasal symptoms in refractory allergic rhinitis with SMD -2.07 at 4 weeks
Allergy & Immunology Meta-analysis
Botulinum toxin type A improves nasal symptoms in refractory allergic rhinitis with SMD -2.07 at 4 weeks Botox helps stubborn nasal allergies, review finds
This meta-analysis of 187 patients with refractory allergic rhinitis found that botulinum toxin type A significantly improved total nasal sy…
For people with nasal allergies that won't quit, a review suggests Botox shots may ease symptoms as well as standard steroid injections or p…
Jun 1, 2026
OnabotulinumtoxinA 72 U reduces masseter prominence versus placebo in adults
Drug Pipeline RCT
OnabotulinumtoxinA 72 U reduces masseter prominence versus placebo in adults Does this shot really shrink a prominent jaw muscle, or is it just a placebo effect?
This Phase 3, randomized, placebo-controlled trial in 376 adults with Grade 4 or 5 masseter muscle prominence found that onabotulinumtoxinA …
An injection shrinks prominent jaw muscles in over half of adults with severe cases, narrowing the lower face quickly with mostly mild side …
Apr 18, 2026
BoNTA injection reduces axillary sweat in Chinese patients with primary hyperhidrosis
Drug Pipeline RCT
BoNTA injection reduces axillary sweat in Chinese patients with primary hyperhidrosis One Shot Stops Excessive Underarm Sweating for Months, Study Finds
This Phase 3, multicenter, randomized, double-blind, placebo-controlled study in 344 Chinese patients with primary axillary hyperhidrosis fo…
A single Botox shot safely cuts underarm sweat by more than half for up to four months in people with excessive sweating.
Apr 18, 2026
Add-on atogepant 60 mg daily reduced monthly migraine days in chronic migraine patients on stable onabotulinumtoxinA
Drug Pipeline Phase III
Add-on atogepant 60 mg daily reduced monthly migraine days in chronic migraine patients on stable onabotulinumtoxinA Adding atogepant to botulinum toxin reduced migraine days in a small study
This Phase 3, multicenter, 24-week, open-label, single arm study evaluated add-on atogepant 60 mg once daily in 75 participants with chronic…
Adding atogepant to botulinum toxin cut migraine days by over 50% for 62% of patients in a study, with most finding it safe and well-tolerat…
Apr 18, 2026
Network meta-analysis of acupuncture interventions for post-stroke central facial paralysis efficacy
Neurology Meta-analysis
Network meta-analysis of acupuncture interventions for post-stroke central facial paralysis efficacy Can acupuncture help restore your smile after a stroke, and which method works best?
This network meta-analysis evaluated 1888 patients with post-stroke central facial paralysis receiving various acupuncture interventions or …
For people struggling with facial weakness after a stroke, combining acupuncture with other treatments often shows better results than acupu…
Frontiers Apr 9, 2026