Hypertension history associates with 2.22-fold higher cognitive impairment risk in AF patients
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Key Takeaway
Consider that hypertension history is associated with higher cognitive impairment risk in AF patients, but causality is not established.
This is a systematic review and meta-analysis of observational studies examining cognitive impairment in patients with atrial fibrillation. The scope was to synthesize evidence on the association between hypertension history, systolic and diastolic blood pressure, and cognitive impairment risk.
The key synthesized finding is that a history of hypertension is associated with an increased risk of cognitive impairment. The pooled effect size from the meta-analysis was an odds ratio of 2.22 (95% CI: 2.15–2.30). The review did not report pooled results for systolic or diastolic blood pressure.
The authors note that the evidence is from observational studies, which cannot establish causality. Limitations of the underlying studies were not detailed in the source. Follow-up duration and absolute risk numbers were not reported.
Practice relevance was not reported. Clinicians should interpret these findings as indicating an association, not a causal link, between hypertension history and cognitive impairment in this population.
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View Original Abstract ↓
BackgroundCognitive impairment manifests as a gradual decline in the ability to perform daily activities. This study evaluates the impact of history of hypertension and blood pressure parameters on cognitive impairment in patients with atrial fibrillation (AF).MethodsWe systematically searched eight databases (CNKI, Wanfang, VIP, CBM, PubMed, Embase, Cochrane Library, Web of Science) from inception to September 7, 2025, for observational studies examining associations between hypertension history, blood pressure parameters, and cognitive impairment in AF patients. Study quality was assessed using NOS (cohort/case-control) and AHRQ (cross-sectional) tools. Meta-analyses were performed separately for odds ratios (OR) and hazard ratios (HR) using RevMan 5.4. Heterogeneity was evaluated with I2 statistic, with sensitivity and subgroup analyses.ResultsA total of 20 studies involving 998,622 AF patients were included. We identified six potential risk factors for cognitive impairment in patients with atrial fibrillation from these 20 studies, three of which (history of hypertension, systolic blood pressure, diastolic blood pressure) were reported in sufficient studies to be included in a meta-analysis. Subgroup meta - analysis of OR showed that history of hypertension is associated with an increased risk of cognitive impairment in patients with atrial fibrillation (OR: 2.22, 95% CI: 2.15–2.30, P
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