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Persistent insomnia in heart failure is associated with higher anxiety and lower functional capacityPersistent insomnia linked to higher anxiety in heart failure patients

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Key Takeaway
Note that persistent insomnia in heart failure is associated with higher anxiety and lower functional capacity.

This secondary analysis of the HF-Wii randomized trial included 400 patients with heart failure across 10 centers in six countries. The study assessed insomnia symptoms at baseline, 3, 6, and 12 months to determine trajectory distributions among patients.

At baseline, 32% (126/400) of patients reported insomnia. Of those, the distribution was categorized as persistent (40%, n=51), fluctuating (38%, n=48), or recovered (21%, n=27). Additionally, 9% of patients without baseline insomnia developed new-onset symptoms at 2 to 3 follow-ups, while 13% developed them at a single time point.

Key associations were found for the persistent insomnia group. Patients with persistent insomnia had higher anxiety (OR = 2.73, P < 0.001) and lower functional capacity (OR = 0.50, P < 0.005). Safety data and tolerability were not reported.

As a secondary analysis, these results indicate associations rather than causal effects. The findings suggest that routine assessment of insomnia trajectories may assist in identifying patients with specific comorbidities like anxiety or limited functional capacity for targeted management.

How this fits prior evidence

How this fits prior evidence: This finding addresses a gap in the clinical management of heart failure by highlighting the impact of persistent insomnia on patient outcomes. While previous coverage noted that CBT-I doubles absolute insomnia remission compared with sleep hygiene, this study specifically identifies how stable insomnia trajectories correlate with anxiety and functional capacity in heart failure populations.

Living with heart failure is physically demanding, but the mental toll of constant sleep struggles can make it even harder. A study of 400 patients across six countries looked closely at how insomnia—the inability to sleep well—changed over a year. They found that about one-third of these patients struggled with insomnia from the start.

The researchers tracked different types of sleep issues. While some people saw their symptoms improve, others faced persistent insomnia. For those whose sleep problems stayed constant, there was a much stronger link to high levels of anxiety. These patients also showed lower functional capacity, which is the ability to perform daily physical activities.

Because this was a secondary analysis of existing data, it shows an association rather than a direct cause. However, the findings suggest that checking for sleep issues early on could help doctors better support patients who are struggling with both heart health and mental well-being.

What this means for you:
Persistent insomnia in heart failure is linked to higher anxiety and lower physical ability.

Common questions

How common is insomnia in people with heart failure?

The study found that 32% of the 400 patients reported having insomnia at the start of the observation period.

Is there a link between sleep and anxiety?

Yes, the data showed that higher levels of anxiety were associated with persistent insomnia. Specifically, those with constant sleep issues had a much stronger link to anxiety symptoms.

Does sleep affect physical ability in these patients?

The study found that lower functional capacity—the ability to perform daily tasks—was linked to persistent insomnia. This suggests that long-term sleep issues may be tied to a person's physical limitations.

Study Details

Study typeRct
Sample sizen = 400
EvidenceLevel 2
Follow-up12.0 mo
PublishedJul 2026
View Original Abstract ↓
AIMS: To describe trajectories of insomnia symptoms over 12 months in patients with heart failure (HF) and to identify characteristics associated with persistent, fluctuating, or low/no insomnia. METHODS AND RESULTS: This secondary analysis used data from the HF-Wii randomized trial, including 400 patients from 10 centres in six countries (Sweden, Italy, Israel, the Netherlands, Germany, and the USA). Insomnia was assessed at baseline, 3, 6, and 12 months using the Minimal Insomnia Symptom Scale. Patients were grouped into insomnia trajectories (persistent, fluctuating, low/no insomnia). Depression and anxiety were measured with the Hospital Anxiety and Depression Scale, well-being with Cantril's Ladder, quality of life with the Minnesota Living with Heart Failure Questionnaire, comorbidity burden with the Charlson Comorbidity Index, and functional capacity with the 6-min walk test. Group differences were examined with ANOVA and chi-square tests; variables with P ≤ 0.05 were entered into multivariate logistic regression. Associations were examined with ANOVA, chi-square, and multivariable logistic regression.At baseline, 126 patients (32%) reported insomnia: 51 (40%) had persistent, 48 (38%) fluctuating, and 27 (21%) recovered. Among 274 without baseline insomnia, 25 (9%) developed insomnia at 2-3 follow-ups and 36 (13%) at one time point. Persistent insomnia was independently associated with higher anxiety (OR = 2.73; P < 0.001) and lower functional capacity (OR = 0.50; P < 0.005). CONCLUSION: A substantial proportion of HF patients experience persistent or fluctuating insomnia. Routine assessment-particularly in those with anxiety or low functional capacity-may aid early detection and guide targeted interventions.
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