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Home › Conditions › Insomnia

Insomnia

Part of Sleep Disorders, Intrinsic

Subtypes of Insomnia

Clinical insomnia 1

34 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Insomnia

199 trials tracked for Insomnia: 61 in phase 3 or 4 and 15 with published results. The most-cited published study has 238 citations.

199Trials tracked
61Phase 3 & 4
0Recruiting
15With published results
Phase distribution
Phase 4 31 Phase 3 30 Phase 2 20 Phase 1 9 Other / NA 109
  1. Phase 3 Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects With Insomnia Disorder Completed · 238 cited
  2. Phase 3 Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep Completed · 238 cited
  3. Phase 4 Reducing Suicidal Ideation Through Insomnia Treatment Completed · 152 cited
  4. Phase 3 Comparing Internet and In-Person Brief Cognitive Behavioral Therapy of Insomnia Completed · 107 cited
  5. Phase 3 Study to Assess the Long Term Safety and Tolerability of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep Completed · 97 cited
  6. Phase 3 The Healthy Patterns Sleep Study Completed · 71 cited
Show 44 more trials
  1. Phase 4 Suvorexant and Trauma Related Insomnia Completed · 26 cited
  2. Phase 3 Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis Completed · 22 cited
  3. Phase 4 Efficacy of Suvorexant in the Treatment of Hot Flash-associated Insomnia Completed · 21 cited
  4. Phase 3 Long-term Study of Lemborexant in Insomnia Disorder (SUNRISE 2) Completed · 17 cited
  5. Phase 3 Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1) Completed · 14 cited
  6. Phase 4 Treatment of Insomnia in Migraineurs Completed · 13 cited
  7. Phase 4 Study to Compare the Awakening Threshold Effects of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs Completed · 10 cited
  8. Phase 4 Suvorexant and Sleep/Delirium in ICU Patients Completed · 9 cited
  9. Phase 4 Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Completed · 5 cited
  10. Phase 4 The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy Completed
  11. Phase 4 To Compare the Effectiveness of Suvorexant vs Placebo on Sleep Pressure in Hypertensives With Insomnia Completed
  12. Phase 4 Eszopiclone in the Treatment of Insomnia and Fibromyalgia Completed
  13. Phase 4 Pimavanserin for Insomnia In Veterans With Posttraumatic Stress Disorder Completed
  14. Phase 4 Efficacy of Suvorexant to Treat Insomnia Related to Bipolar Disorder Completed
  15. Phase 4 Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Completed
  16. Phase 4 Safety and Efficacy of Chronic Hypnotic Use 2 Completed
  17. Phase 4 A Pilot Study of Suvorexant for Insomnia in Parkinson Disease Completed
  18. Phase 4 A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia Completed
  19. Phase 4 CBT-I or Zolpidem/Trazodone for Insomnia Completed
  20. Phase 4 A Study to Find Out if Daridorexant is Safe and Efficacious in Patients With Insomnia and Comorbid Nocturia Completed
  21. Phase 4 Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia Completed
  22. Phase 4 Treating Insomnia and Improving Metabolic Health in Midlife Women With Insomnia Completed
  23. Phase 4 A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia Completed
  24. Phase 4 Treatment of Insomnia and Glucose Metabolism Completed
  25. Phase 4 Efficacy and Safety of Temazepam in HIV Seropositive Patients With Insomnia Completed
  26. Phase 4 Long Term Treatment With Zolpidem: Nightly and Intermittent Dosing Completed
  27. Phase 4 The Effects of Eszopiclone and Lexapro on Prefrontal Glutamate and GABA in Depression With Anxiety and Insomnia Completed
  28. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  29. Phase 4 Mechanisms of Sleep Latency and Health: The Effect of a Melatonin Receptor Agonist in Inflammation and Insulin Resistance Completed
  30. Phase 4 The Treatment of Insomnia in Patients With HIV Disease Completed
  31. Phase 4 Facilitation of Zolpidem (≥10 mg) Discontinuation Through Use of Ramelteon in Subjects With Chronic Insomnia Completed
  32. Phase 4 Eszopiclone Treatment & Cortisol Responsivity Completed
  33. Phase 4 Study of the Insomnia in Patients With Low Back Pain Completed
  34. Phase 3 Two Contrasting Interventions for Sleep Management Completed
  35. Phase 3 Treatment of Insomnia in Elderly Sleep Apnea Patients With Ramelteon (TAK 375) Completed
  36. Phase 3 A Study to Evaluate Next-Dose Transition From Zolpidem to Lemborexant (LEM) for the Treatment of Insomnia Completed
  37. Phase 3 Safety and Efficacy Study of Suvorexant in Participants With Primary Insomnia - Study B (MK-4305-029) Completed
  38. Phase 3 Almorexant (ACT 078573) in Adult Subjects With Chronic Primary Insomnia Completed
  39. Phase 3 Safety and Efficacy Study of Suvorexant in Participants With Primary Insomnia - Study A (MK-4305-028) Completed
  40. Phase 3 VEC-162 Study in Healthy Adult Volunteers in a Model of Insomnia Completed
  41. Phase 3 Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709) Completed
  42. Phase 3 A Six Week, Double-Blind Randomized, Efficacy and Safety, Sleep Lab Trial With Esmirtazapine (Org 50081) (P05707) Completed
  43. Phase 3 Efficacy and Safety of Circadin® 2 mg in the Treatment of Primary Insomnia Patients Completed
  44. Phase 3 A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150) Completed

Showing the 50 most-cited and recently-updated of 199 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Daridorexant improves objective and subjective insomnia markers with dose-dependent efficacy across multiple trials
Drug Pipeline Meta-analysis
Daridorexant improves objective and subjective insomnia markers with dose-dependent efficacy across multiple trials New data shows daridorexant helps people with insomnia sleep better
This meta-analysis of 2905 patients found that daridorexant outperformed placebo in both objective and subjective sleep indicators for insom…
Daridorexant shows promise for treating insomnia by improving sleep time and quality, though some side effects are linked to specific doses.
Frontiers Jul 25, 2026
MHT and CBCTi trial protocol evaluates insomnia treatment in perimenopausal women
Psychiatry RCT
MHT and CBCTi trial protocol evaluates insomnia treatment in perimenopausal women New trial plans to test hormone therapy for menopause insomnia
This study protocol describes a randomized controlled trial of 222 perimenopausal women with insomnia and climacteric symptoms. The study wi…
A new clinical trial aims to see if combining hormone therapy with behavioral techniques helps women manage insomnia during the menopausal t…
medRxiv Jul 24, 2026
Sedative-hypnotic use associated with OR 1.29 for incident Alzheimer's Disease
Neurology Meta-analysis
Sedative-hypnotic use associated with OR 1.29 for incident Alzheimer's Disease Meta-analysis links sedative-hypnotic drug use to higher Alzheimer risk
This meta-analysis of observational cohort and nested case-control studies involving 721,354 adults without baseline dementia found that sed…
A large study suggests a link between the use of common sleep medications like benzodiazepines and an increased risk of developing Alzheimer…
Jul 22, 2026
Persistent insomnia in heart failure is associated with higher anxiety and lower functional capacity
Cardiology RCT
Persistent insomnia in heart failure is associated with higher anxiety and lower functional capacity Persistent insomnia linked to higher anxiety in heart failure patients
This secondary analysis of a randomized trial involving 400 patients with heart failure identified distinct insomnia trajectories over 12 mo…
A new look at heart failure data shows that lasting sleep issues are tied to higher anxiety and lower physical ability.
Jul 16, 2026
CBT-I doubles absolute insomnia remission compared with sleep hygiene across 77 randomized controlled trials
Psychiatry Meta-analysis
CBT-I doubles absolute insomnia remission compared with sleep hygiene across 77 randomized controlled trials CBT-I Doubles Insomnia Remission Compared to Sleep Hygiene
This systematic review and network meta-analysis of 5,731 participants found that CBT-I, SRT+SCT, SRT, and SCT were associated with higher r…
Behavioral therapy for insomnia doubles remission rates, and simpler versions may work too.
medRxiv Jul 9, 2026
Refugee and asylum seeker status is associated with high prevalence of clinically significant sleep disturbances
Pediatrics Meta-analysis
Refugee and asylum seeker status is associated with high prevalence of clinically significant sleep disturbances Refugees face high rates of insomnia and poor sleep
This meta-analysis of 66 studies involving 42,956 participants indicates that refugees and asylum seekers experience significant insomnia se…
Nearly half of refugees experience serious sleep problems, a new analysis finds, with insomnia scores bordering on moderate clinical insomni…
Jul 3, 2026
Non-pharmacological interventions may improve sleep quality, quality of life, and anxiety in lung cancer patients
Oncology Meta-analysis
Non-pharmacological interventions may improve sleep quality, quality of life, and anxiety in lung cancer patients Non-drug treatments may improve sleep and anxiety in lung cancer
This systematic review and meta-analysis of 2604 lung cancer patients found that non-pharmacological interventions may have a positive effec…
New data suggests that non-drug therapies can help lung cancer patients sleep better, feel less anxious, and improve their overall quality o…
Jun 29, 2026
Exercise combined with CBT is the most consistently supported intervention for improving insomnia sleep quality
ENT (Otolaryngology) Meta-analysis
Exercise combined with CBT is the most consistently supported intervention for improving insomnia sleep quality Exercise combined with therapy shows promise for treating insomnia
This systematic review and network meta-analysis of 31 RCTs involving 2,457 participants found that exercise combined with cognitive behavio…
Combining exercise with cognitive behavioral therapy may improve sleep quality and help people fall asleep faster when dealing with chronic …
Frontiers Jun 20, 2026
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63
Primary Care & Family Medicine Meta-analysis
Mind-body therapies significantly improve sleep quality in perinatal women with a mean difference of -2.63 Mind-body therapies improve sleep quality for perinatal women
This systematic review and meta-analysis of 13 randomized controlled trials involving 782 participants found that mindfulness, Pilates, and …
Yoga, Pilates, and mindfulness may offer a helpful way for pregnant and new mothers to improve their sleep quality during a demanding time.
Frontiers Jun 19, 2026
Exercise improves sleep questionnaire scores for sedentary adults with insomnia across multiple modalities
Physical Medicine & Rehab Sys. Review
Exercise improves sleep questionnaire scores for sedentary adults with insomnia across multiple modalities Different types of exercise improve sleep for people with insomnia
This network meta-analysis of 31 RCTs involving 1,420 participants indicates that various exercise modalities significantly improve sleep qu…
New data shows that various forms of exercise, from aerobic to mind-body routines, can significantly improve sleep quality for those with in…
Jun 15, 2026
TCM nursing techniques combined with music-based interventions improve sleep quality in older adults
Psychiatry Meta-analysis
TCM nursing techniques combined with music-based interventions improve sleep quality in older adults Chinese Medicine and Music Improve Sleep in Older Adults
This systematic review and meta-analysis of 838 participants found that traditional Chinese medicine (TCM) nursing techniques combined with …
A review of 838 older adults finds that combining traditional Chinese nursing techniques with music boosts sleep and eases anxiety and pain.
Frontiers Jun 11, 2026
Nurse-administered acupressure reduces PSQI scores by MD -7.61 in menopausal insomnia
Physical Medicine & Rehab Meta-analysis
Nurse-administered acupressure reduces PSQI scores by MD -7.61 in menopausal insomnia Non-drug treatments improve sleep in women after menopause
This meta-analysis of randomized controlled trials in 1648 women after natural menopause found that non-pharmacological interventions, parti…
A large review of trials shows non-drug methods like therapy and exercise significantly improve sleep scores for post-menopausal women.
Jun 1, 2026

Questions about Insomnia

Can breathwork reduce stress and anxiety in paramedic students with insomnia?

Yes, a 12-week RCT found that slow diaphragmatic breathwork significantly reduced stress, anxiety, and insomnia in paramedic students.

Full answer →

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