CI-AKI in ACS patients undergoing PCI was associated with a 4.7-fold increased hazard of death within 90 days.

This prospective cohort study examined the impact of contrast-induced acute kidney injury (CI-AKI) on survival in 192 patients with acute coronary syndrome undergoing percutaneous coronary intervention. The primary outcome assessed was short- to medium-term survival over a 90-day follow-up period. Secondary analyses identified factors associated with the development of CI-AKI.

CI-AKI occurred in 33% of the study population. Among patients who developed CI-AKI, mortality was 15% higher compared to those without the condition. Statistical analysis revealed a 4.7-fold increased hazard of death for patients with CI-AKI. This association remained significant after adjustment for other variables, identifying CI-AKI as an independent predictor of mortality.

Factors associated with the development of CI-AKI included advanced age, hypertension, chronic kidney disease, use of vasoactive drugs, and cardiorespiratory arrest. The study did not report specific adverse events, discontinuations, or tolerability data related to the interventions or the condition itself. Funding sources and potential conflicts of interest were not reported in the provided data.

Key limitations include the lack of reported setting details and the absence of data on specific adverse events or discontinuations. As an observational study, the findings indicate association rather than causation. The practice relevance underscores the importance of early identification and preventive strategies for CI-AKI in this high-risk population to mitigate potential mortality risks.