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Pooled prevalence of diabetic kidney disease among Brazilian adults is 27.06% across 46 studiesAbout 27% of Brazilian adults with diabetes have kidney disease

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Key Takeaway
Note that the pooled prevalence of diabetic kidney disease in Brazilian adults is 27.06% with high heterogeneity.

This systematic review with meta-analysis evaluates the prevalence of diabetic kidney disease (DKD) among 24,893 Brazilian adults across 46 studies. The study synthesizes data using various diagnostic criteria and demographic factors to identify trends in DKD prevalence within the Brazilian population.

The pooled prevalence of DKD was determined to be 27.06% (95% CI 22.40-32.29). Specific subgroups showed varying rates: 33.28% for patients with a disease duration of ≥10 years, compared to 24.32% for those with <10 years. Prevalence was reported as 28.93% in Type 1 Diabetes and 28.61% in Type 2 Diabetes. Regional analysis showed a higher prevalence of 41.0% in the South region.

The authors note high heterogeneity in the data and limited information for the North and Northeast regions of Brazil. These limitations suggest that while the pooled figure provides a broad overview, regional specificities may vary. The findings highlight the need for multicenter studies using standardized definitions to improve national surveillance and clinical management of DKD.

How this fits prior evidence

This meta-analysis addresses a gap in understanding the prevalence of diabetic kidney disease within the Brazilian population. While prior coverage has focused on pharmacological interventions like finerenone for heart failure risk or retatrutide for glycemic control, this study provides specific epidemiological data on DKD prevalence (27.06%) and identifies how duration and region impact these figures.

A large meta-analysis of 46 studies involving nearly 25,000 Brazilian adults with diabetes found that about 27% have diabetic kidney disease (DKD). This condition damages the kidneys and can lead to kidney failure if not managed early.

The study looked at how common DKD is across different groups. People who had diabetes for 10 years or more had a higher rate (33%) compared to those with diabetes for less than 10 years (24%). The rates were similar for type 1 (29%) and type 2 diabetes (29%).

How DKD was diagnosed also mattered. When using only a urine test for protein (albuminuria), the rate was 32%. When using only a blood test for kidney function (eGFR), it was 18%. Using both tests together gave a rate of 31%. This shows that using both tests gives a more complete picture.

There were also differences by region. The South region of Brazil had the highest rate at 41%, but data from the North and Northeast were limited. The researchers noted high variation between studies, so the numbers should be interpreted with caution.

Overall, this study highlights that DKD is common among Brazilian adults with diabetes. It also shows the need for standard ways to diagnose and track the condition across the country to improve care and prevention.

What this means for you:
About 1 in 4 Brazilian adults with diabetes have kidney disease, with higher risk after 10 years of diabetes.

Common questions

How common is kidney disease in people with diabetes?

The study found that approximately 27.06% of Brazilian adults with diabetes have diabetic kidney disease (DKD). This percentage can change based on the specific medical criteria used for diagnosis, such as looking at protein in the urine or measuring filtration rates.

Does the length of time living with diabetes affect kidney health?

Yes, the data shows a link between the duration of diabetes and kidney issues. People who have had diabetes for 10 years or more showed a higher prevalence of kidney disease at 33.28%, while those diagnosed for less than 10 years had a lower rate of 24.32%.

Is there a difference between Type 1 and Type 2 diabetes regarding kidney health?

The study found similar rates for both types. The prevalence of diabetic kidney disease was reported at 28.93% for individuals with Type 1 diabetes and 28.61% for those with Type 2 diabetes.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
This systematic review assesses the prevalence of diabetes kidney disease (DKD) in Brazil, examining geographical variations and associated risk factors. Following PRISMA guidelines and PROSPERO registration, searches were conducted in PubMed, EMBASE, and LILACS for studies up to and including December 2025. Two researchers independently performed screening, data extraction, and quality assessment. Pooled prevalence was estimated using a random-effects meta-analysis (generalized linear mixed model). Subgroup analyses included diabetes type, duration, diagnostic criteria, healthcare setting, and region. A total of 46 studies were included (n = 24,893 individuals). The pooled prevalence of DKD among Brazilian adults was 27.06% (95% CI 22.40-32.29; I 98%). Higher prevalence was associated with longer diabetes duration: 33.28% for ≥10 years versus 24.32% for <10 years. Estimates varied by diabetes type: type 1, 28.93% [18.06-42.92] and type 2, 28.61% [20.95-37.73]. Diagnostic criteria significantly influenced results: albuminuria only (32.30%), estimated glomerular filtration rate (eGFR) only (17.70%), and combined eGFR/albuminuria (30.69%). Regional data showed higher prevalence in the South (41.0%), with limited data available for the North and Northeast. High heterogeneity highlights the need for multicenter studies using standardized definitions to improve national surveillance.
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