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Children with Type 1 Diabetes Mellitus show higher DMFT index for permanent teethChildren with Type 1 Diabetes Have Higher Risk of Cavities

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Key Takeaway
Note that while children with Type 1 Diabetes Mellitus have higher DMFT scores, no causal link to caries prevalence was found.

This meta-analysis evaluates the relationship between Type 1 Diabetes Mellitus and dental health in children and adolescents. The analysis focused on the decayed, missing, and filled teeth (DMFT) index for permanent teeth and the prevalence of dental caries.

Findings indicate that children with Type 1 Diabetes Mellitus have a higher DMFT index for permanent teeth compared to the control group (95% CI: 0.06 to 0.31; I2 = 26.6%). Despite this association, a Mendelian randomization analysis did not reveal a statistically significant causal relationship between Type 1 Diabetes Mellitus and the prevalence of dental caries (95% CI: 0.94 to 1.02; P = 0.308).

While the data suggest an increased risk of dental caries in children with Type 1 Diabetes Mellitus, the lack of a statistically significant causal link via Mendelian randomization suggests that the observed difference may not be directly caused by the condition itself. Clinical implications for pediatric dental care in this population remain nuanced due to these findings.

How this fits prior evidence

This meta-analysis addresses a gap in understanding the link between Type 1 Diabetes Mellitus and dental health. While it confirms that children with Type 1 Diabetes Mellitus have a higher DMFT index, it provides a nuanced view by showing no statistically significant causal relationship via Mendelian randomization. This follows previous evidence that dairy-derived components may support remineralization and reduce inflammation in periodontal tissues.

A review of existing data looked at the relationship between Type 1 Diabetes Mellitus (T1DM) and dental health in children and adolescents. The study specifically measured the number of decayed, missing, or filled teeth in permanent teeth to see if those with T1DM faced higher risks.

The results showed that children with Type 1 Diabetes had a higher number of decayed, missing, and filled teeth compared to children without the condition. However, a specific type of analysis called Mendelian randomization did not find a statistically significant causal link between having Type 1 Diabetes and the overall prevalence of dental caries.

Because the evidence on the exact cause is not clear, these findings are not used to change standard medical practices. While the data shows a link between the condition and more cavities, it does not prove that the diabetes itself causes the decay. Parents and children with Type 1 Diabetes should continue to follow standard dental care advice.

What this means for you:
Children with Type 1 Diabetes have more decayed teeth, but a direct causal link is not yet confirmed.

Common questions

Do children with Type 1 Diabetes have more cavities?

Yes, the study found that children and adolescents with Type 1 Diabetes had a higher number of decayed, missing, and filled teeth compared to a control group. This indicates a higher risk for dental issues in children living with this condition.

Does Type 1 Diabetes cause dental decay?

The study did not find a statistically significant causal relationship between Type 1 Diabetes and the prevalence of dental caries. While the risk is higher, the specific analysis did not confirm that the condition directly causes the decay.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
IntroductionThis study aimed to examine the relationship between type 1 diabetes mellitus (T1DM) and dental caries among children and adolescents through a meta-analysis, and to assess the potential causal link between these conditions using Mendelian randomization (MR) techniques.MethodsA comprehensive literature review was carried out to identify relevant studies, and meta-analyses were conducted utilizing Stata statistical software. For the MR analyses, summary-level data from genome-wide association studies (GWAS) regarding T1DM and dental caries in childhood and adolescence were gathered.ResultsThe meta-analysis indicated that the decayed, missing, and filled teeth (DMFT) index for permanent teeth was notably higher in children with T1DM compared to the control group, yielding a pooled standardized mean difference (SMD) of 0.19 (95% CI: 0.06–0.31; I2 = 26.6%). However, the MR analysis did not reveal a significant causal relationship between T1DM and the prevalence of dental caries in children and adolescents (OR = 0.98, 95% CI: 0.94–1.02, P = 0.308).DiscussionWhile children and adolescents with T1DM are at an elevated risk for dental caries, no statistically significant causal link was observed.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/view/177851 identifier CRD2020177851.
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