Mode
Text Size
Log in / Sign up

Meta-analysis finds 15.4% pooled TTI prevalence in Cameroonian blood donors, higher risk in family donorsHow many blood donations in Cameroon carry dangerous infections?

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note high TTI prevalence and elevated risk from family donors in Cameroon based on observational meta-analysis.

A systematic review and meta-analysis synthesized data from 36 studies and 72 datasets, representing approximately 105,000 blood donations collected primarily from health facilities in Yaoundé (51.4%), Douala (25.7%), and Bamenda (8.6%), Cameroon. The study aimed to determine the prevalence, patterns, and determinants of major transfusion-transmitted infections (TTIs).

The primary analysis found a pooled TTI proportion of 15.4% (95% CI: 12.7% to 18.2%). The pooled proportion of coinfections was 1.5%, with the most prevalent coinfection being HBV + HCV at 3.4%. The analysis indicated that the risk for HIV and T. pallidum infection was consistently higher in family donors, though specific effect sizes were not reported.

Key limitations include a paucity and underreporting of data from certain regions, diagnostic inconsistencies even within the same assays, and a lack of evidence on determinants, residual risk, and the extent of occult hepatitis B infection. The authors conclude that high-quality studies are needed to inform public health policymakers and assist in developing better blood safety strategies and services in Cameroon.

When someone in Cameroon needs a blood transfusion, what are the odds the donated blood carries a dangerous virus? A new analysis of over 100,000 donations from 36 studies paints a concerning picture. It found that a pooled 15.4% of donations tested positive for at least one major infection—like HIV, hepatitis B, hepatitis C, or syphilis. The risk for HIV and syphilis was consistently higher in blood given by family members compared to other donors.

The study, which pooled data from many smaller reports, also found that about 1.5% of donations had more than one infection, with hepatitis B and C appearing together most often. This research gives us a crucial, if incomplete, look at the challenge of keeping the blood supply safe in Cameroon. Most of the data came from major cities like Yaoundé and Douala, leaving other regions less understood.

It’s important to read these numbers with clear eyes. The findings come from observational studies, not a single controlled trial. The authors note that diagnostic tests were inconsistent across studies, and key information—like what drives these infection rates or the true risk of a contaminated donation slipping through—is still missing. This analysis doesn’t prove that one type of donor causes more infections; it shows an association that needs deeper investigation. Ultimately, this work underscores an urgent need for better, more consistent data to build safer blood systems.

What this means for you:
About 15% of blood donations in a Cameroon analysis carried a transmissible infection, with higher HIV/syphilis risk in family donors.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
OBJECTIVES: This systematic review and meta-analysis (SRMA) was designed to determine the prevalence, patterns, and determinants of major transfusion-transmitted infections (TTIs), to address this gap, and to propose solutions to the current identified blood transfusion-related challenges in Cameroon. METHODS: Pooled estimates of TTI-related infection rates, that is, human immunodeficiency virus - HIV, hepatitis B/C viruses - HBV/HCV, and Treponema pallidum, were computed using random effects models. Subgroup and sensitivity analyses were performed, and methodological bias analysis was assessed using the Joanna Briggs Institute tools. RESULTS: A total of 36 studies, spanning 72 datasets for ∼105,000 blood donations, were included. Most of them were conducted in family donors attending health facilities of three towns, viz. Yaoundé (51.4%), Douala (25.7%), and Bamenda (8.6%). The pooled proportion of TTIs was 15.4% (95% CI: 12.7-18.2%), and was significantly modulated by several variables (e.g., testing strategy, area). These pathogens could occur as coinfections at a pooled proportion of 1.5%, with HBV + HCV being the most prevalent (3.4%). Across studies, the risk for HIV and T. pallidum infection was consistently higher in family donors. Several challenges, including diagnostic inconsistencies (even within the same assay) and a lack of evidence data on determinants, residual risk, and the extent of occult hepatitis B infection, were identified, primarily due to the paucity and underreporting of data in certain regions. CONCLUSIONS: The review outlines a significant burden of HIV, HBV, HCV, and T. pallidum in blood donors. High-quality studies are needed to fill these gaps to inform public health policymakers and assist the development and implementation of better blood safety strategies and services.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.