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Personalized risk information improves screening intent for colorectal cancer among average risk patientsPersonalized risk info may help patients choose colorectal screenings

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Key Takeaway
Consider personalized risk information to increase stool test intent but note it may decrease colonoscopy intent.

The study investigated the effect of a decision aid containing personalized advanced colorectal neoplasia risk information compared to generic information. The primary goal was to determine if personalized risk data influenced patient screening intent and informed concordance for colorectal cancer screening among average risk individuals.

Results indicated that patients receiving personalized risk information showed higher odds of intending to undergo screening and specifically for stool tests. Conversely, these same patients showed lower odds of intending to undergo a colonoscopy. While the primary outcome of informed concordance did not show significant effects overall, a moderation analysis suggested higher odds of informed concordance in one specific health system where providers received personalized notifications.

Several limitations were noted, including the study being conducted in a single city and limited to English-speaking patients. Additionally, there was a low enrollment of patients at high-average risk for advanced colorectal neoplasia. Clinicians may find that personalized risk information serves as a tool to influence patient preferences for specific screening modalities, but the impact on overall informed concordance may vary depending on the specific healthcare environment.

When it comes to cancer, the most important step is often the one you take before you even feel sick. For many people, colorectal cancer screening is a vital part of staying healthy. However, choosing the right test can feel overwhelming. Some people might not know which test is best for them, or they might feel unsure about the risks and benefits of different options. This uncertainty can lead to people putting off their screenings entirely.

To see if personalized information could help, researchers conducted a study involving over 1,000 patients between the ages of 50 and 75. These individuals were at average risk for colorectal cancer and were preparing for upcoming clinic appointments. The researchers split the group into two. One group received a decision aid that included personalized information about their specific risk for advanced colorectal neoplasia (which are precancerous growths). The other group received a decision aid with only general information. Additionally, some doctors received personalized risk notes for their patients, while others received standard notifications.

The results showed that patients who received personalized risk information were much more likely to say they intended to get screened at all. Specifically, they showed a much higher interest in taking a stool test compared to the group that received only general information. Interestingly, the group with personalized information showed a lower interest in undergoing a colonoscopy. While the study did not show a clear, universal change in how well patients and doctors agreed on the final plan across all settings, it did find that in one specific health system, giving doctors personalized notes helped patients feel more in sync with their providers. It is important to keep a few things in mind before making big changes. This study was conducted in only one city and only included English-speaking patients. Because of this, the results might not apply to everyone in every location. Also, the study did not have a large number of patients who were at a high risk for advanced growths, which could affect how the data looks for some people.

For now, this research suggests that giving patients specific, personalized information about their risks can be a powerful tool. It helps them feel more informed when making big decisions about their health. If you are approaching your next screening, you might find it helpful to ask your doctor for specific details about your personal risk level to help you choose the best path forward.

What this means for you:
Personalized risk information can increase a patient's intent to get screened and take stool tests.

Study Details

Study typeRct
Sample sizen = 1,084
EvidenceLevel 2
PublishedNov 2026
View Original Abstract ↓
PurposeTo measure the impact of a personalized message about current risk of having advanced colorectal neoplasia (ACN; colorectal cancer [CRC] or advanced precancerous polyp) on informed concordance and CRC screening decision-making outcomes.MethodsA total of 1,084 patients, aged 50 to 75 y, with an upcoming clinic appointment, due for CRC screening, and at average risk for CRC were randomized to view a decision aid (DA) about CRC screening with or without personalized ACN risk information. Providers were randomized to receive CRC screening notifications with or without each patient's personalized ACN risk. Patients completed surveys before (T0), immediately after viewing the DA (T1), and after their clinic visit (T2) to assess informed concordance (primary outcome), screening intent, decisional conflict, knowledge, perceived personal risk, and perceived shared decision making. Analysis of covariance and logistic regression models compared intended screening behavior and decision-making outcomes by intervention groups.ResultsAt T1, participants (mean age 56.5 y, 59.7% female) sent the personalized rather than the generic DA had higher odds of intending to be screened with any test (odds ratio [OR] = 1.55, confidence interval [CI] = 1.03, 2.33) and to have a stool test (OR = 2.17, CI = 1.62, 2.91) and lower odds of intending to undergo colonoscopy (OR = 0.58, CI = 0.43, 0.79). There were no statistically significant effects of either intervention on informed concordance. Moderation analysis, however, showed that for one health system, participants whose provider was sent the personalized notification had higher odds of informed concordance.LimitationsSingle Midwestern city, English-speaking patients only, low enrollment of patients at high-average risk for ACN.ConclusionProviding patients with a personalized message about their ACN risk increased the intent to be screened and to do a stool test and decreased the intent to undergo colonoscopy. For one health system, sending providers the ACN risk message increased the odds of informed concordance.ClinicalTrials.gov: NCT04683731HighlightsA personalized message about patients' advanced colorectal neoplasia (ACN) risk, provided as part of a decision aid, increased patients' intent to be screened with any test and to have a stool test and decreased their intent to be screened with colonoscopy.A personalized message about patients' ACN risk, included in a decision aid sent to patients or in a screening notification sent to their providers, had no significant effect on informed concordance.At one health system, a personalized message sent to providers about their patients' ACN risk increased the odds of informed concordance between the patients' intended screening test and the test received.
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