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Anesthesiology & Pain Medicine
Meta-analysis
Perioperative nefopam failed to lower morphine needs or pain scores in spine surgery patients undergoing randomised trials
Perioperative nefopam did not reduce morphine use or pain after spine surgery
A systematic review of five hundred fifty-three spine surgery patients found that adding nefopam did not decrease twenty-four hour morphine …
A review of spine surgery patients found that taking nefopam did not lower morphine use or pain scores in the first few days after the opera…
May 22, 2026
Anesthesiology & Pain Medicine
RCT
Opioid-sparing PCA non-inferior to opioid PCA for pain after total knee arthroplasty
Opioid-sparing pain control after knee replacement shows similar pain relief with less nausea
A randomized controlled trial of 98 patients undergoing total knee arthroplasty found an opioid-sparing PCA regimen (ketorolac and nefopam) …
A new pain method after knee replacement works just as well as standard care but cuts nausea from 35% down to 12%.
Apr 2, 2026