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Psychiatry
Meta-analysis
Acupuncture Plus Antidepressants Lowers HAMD Scores in Chinese Depression Patients
Acupuncture combined with antidepressants may improve depression scores
In a network meta-analysis of 7,031 patients in China, adding acupuncture to SSRIs or SNRIs reduced HAMD depression scores more than SSRI mo…
Combining acupuncture with standard antidepressants may lead to greater reductions in depression scores than using antidepressants alone.
Frontiers
Oct 20, 2026
Psychiatry
Meta-analysis
Lower baseline IL-2 and IL-6 levels signal potential antidepressant treatment response in Major Depressive Disorder
Specific markers may help predict response to depression medication
This meta-analysis of baseline peripheral inflammatory biomarkers in adults with Major Depressive Disorder found no significant difference i…
New data suggests that certain inflammatory markers in the blood could help predict which patients will respond to common antidepressants.
Sep 20, 2026
Psychiatry
Meta-analysis
No significant association between BDNF genotypes and remission in major depressive disorder patients treated with antidepressants
Genetic markers do not predict antidepressant success in major depression
This meta-analysis review examined 599 Caucasian patients with a major depressive episode treated with SSRIs, SNRIs, or TCAs. The analysis f…
A large review found that specific genetic markers do not predict who will recover from depression when taking common antidepressant medicat…
Jun 1, 2026
Psychiatry
RCT
Adjunctive JNJ-42165279 fails to improve depression in SSRI/SNRI inadequate responders
Early trial finds new drug did not help depression in patients already on antidepressants
This phase 2a double-blind RCT tested adjunctive JNJ-42165279 25 mg daily versus placebo in 153 adults with major depressive disorder with a…
A small early study found a new drug did not improve depression symptoms for patients already taking standard antidepressants.
May 1, 2026
Genetics & Precision Medicine
Meta-analysis
Meta-analysis identifies two genomic loci associated with antidepressant non-response in 135,471 individuals
Why do antidepressants fail for some people? New genetic clues emerge
A genome-wide association meta-analysis of 135,471 individuals prescribed antidepressants identified two novel genomic loci associated with …
Millions struggle to find working antidepressants, but new genetic data reveals why some fail and suggests other drug options for treatment …
Apr 2, 2026