Mode
Text Size
Log in / Sign up

Combined nutrition and exercise improves physical performance in patients on hemodialysisCombined nutrition and exercise improve physical performance in dialysis patients

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider combined nutrition and exercise to improve gait speed and 6MWT distance in patients on hemodialysis.

This meta-analysis evaluated the impact of combined nutrition plus exercise interventions (including oral supplements and various forms of physical activity) compared to nutritional intervention alone, exercise alone, or no intervention in 231 patients on hemodialysis. The analysis focused on physical performance and secondary outcomes such as body composition and quality of life.

The synthesis indicates that the combined intervention significantly improved several physical performance metrics: 6MWT distance increased by 45.17 m (95% CI 12.60-77.75), gait speed increased by 0.09 m/s (95% CI 0.02 to 0.17), and TUG time decreased by 1.44 s (95% CI -2.63 to -0.25). Conversely, no significant differences were found for sit-to-stand tests, lean body mass, BMI, dietary intake, or quality of life.

The authors note that the evidence for all outcomes is of very low certainty. While the combined intervention showed association with improved physical performance in hemodialysis patients, it did not show clear benefits for body composition or quality of life. Clinical application should be interpreted with caution due to these limitations.

How this fits prior evidence

This meta-analysis addresses a gap in managing functional outcomes for patients with Chronic Kidney Disease (CKD). While previous coverage noted the high prevalence of CKD in certain regions and the role of metabolic factors like insulin resistance in age-related diseases, this study specifically focuses on physical performance outcomes for those already undergoing hemodialysis.

Living with chronic kidney disease often means dealing with significant physical limitations. For those on hemodialysis, staying mobile is a major challenge. A review of several trials looked at how combining nutrition with exercise—such as resistance training or aerobic activity—affects these patients compared to doing only one or neither.

The data showed that patients who received both nutritional supplements and exercise saw improvements in physical performance. Specifically, they walked further during six-minute tests and moved at faster speeds. They also performed better on timed up and go tests, which measure how quickly a person can stand and move. However, the study did not find significant changes in body mass index, muscle mass, or overall quality of life.

It is important to note that while these improvements were observed, the researchers noted a very low certainty of evidence for all outcomes. Additionally, some patients reported gastrointestinal issues during the program. Because the evidence is still limited, patients should talk to their doctors about how these combined programs might fit into their specific care plan.

What this means for you:
Combining nutrition and exercise can improve walking speed and distance for people on hemodialysis.

Common questions

Does combining diet and exercise help with mobility?

Yes, the data shows that patients on hemodialysis who received both nutritional supplements and exercise improved their walking distance by an average of 45.17 meters and increased their gait speed. They also showed better results in timed up and go tests.

What kind of exercises were used?

The study included various types of physical activity, including resistance training, aerobic exercise, and neuromuscular electrical stimulation. These were combined with oral nutritional supplements to target physical performance.

Are there any side effects to this approach?

Some patients reported gastrointestinal symptoms as an unfavorable outcome during the intervention. You should discuss these potential issues and your specific health needs with your doctor.

Study Details

Study typeMeta analysis
EvidenceLevel 1
Follow-up216.0 mo
PublishedAug 2026
View Original Abstract ↓
OBJECTIVE: Although nutritional and exercise interventions in mixed populations of non-dialysis and dialysis chronic kidney disease patients can improve muscle health, no study has specifically targeted dialysis patients or assessed their dietary intake. This systematic review and me-ta-analysis examined whether combined interventions improve physical performance, nutritional status, dietary intake, and quality of life (QOL) in adults receiving dialysis. METHODS: Following the PRISMA 2020 statement (PROSPERO CRD42024543470, registered on May 16, 2024), PubMed, Ichushi Web, and Web of Science were searched to September 30, 2024 for randomized, cluster-randomized, or crossover trials comparing combined nutrition plus exercise with sole either alone or with no intervention in adults (≥18 years) on hemodialysis or peritoneal dialysis. Favorable outcomes included physical performance, skeletal muscle mass, body mass index, energy and protein intake, QOL, and mortality, whereas the unfavorable outcome was gastrointestinal symptoms. Random-effects meta-analyses calculated mean differences (MDs) with 95% confidence intervals (CIs). RESULTS: Eight trials with 231 hemodialysis patients were eligible; seven contributed to quantitative synthesis. Nutritional interventions involved mainly oral supplements, and exercise (resistance, aerobic, or neuromuscular electrical stimulation) was performed two to three times/week for 3-12 months. Combined therapy significantly improved the 6MWT distance (MD 45.17 m, 95% CI 12.60-77.75), gait speed (MD 0.09 m/s, 95% CI 0.02 to 0.17), and TUG time (MD -1.44 s, 95% CI -2.63 to -0.25). No significant differences were observed in the Sit-to-Stand test, lean body mass, BMI, intake, or QOL. CONCLUSIONS: Compared with nutritional intervention alone, combined nutrition and exercise intervention was associated with improved physical performance outcomes in hemodialysis patients but showed no clear benefit for dietary intake, body composition, or QOL. The certainty of evidence was very low for all outcomes.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.