Pre-admission statin use linked to better 30-day outcomes after aneurysmal SAH
Photo by Gizem Nikomedi / Unsplash
Key Takeaway
Interpret pre-admission statin use in aSAH as associated with better 30-day outcomes, but causality is unproven and benefit wanes by 90 days.
This real-world observational study examined the association between pre-admission statin use and outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). Data were collected from four Chinese tertiary medical centers, including 1,431 patients, of whom 821 met inclusion criteria (367 statin users, 454 non-users). After propensity score matching, each group had 220 patients.
The primary outcome was favorable outcome at 30 days, defined as modified Rankin Scale score 0-2. Pre-admission statin use was associated with a higher likelihood of favorable outcome (OR 3.67, 95% CI 2.46-5.47). However, this benefit did not extend to 90-day prognosis.
Safety and tolerability data were not reported. Limitations include the observational design, which precludes causality, and effect variation according to baseline LDL-C levels and alcohol consumption. The study population was from Chinese centers, limiting generalizability.
Clinicians should interpret these results cautiously. The association requires confirmation by multicenter, international randomized controlled trials before any practice changes.
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View Original Abstract ↓
Subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysms is a severe stroke subtype with a high mortality rate. Statins, noted for cholesterol-independent benefits, are being studied as potential treatments, but their effectiveness is debated. This study assesses the impact of pre-admission statin therapy on aneurysmal SAH outcomes.
This was a multicenter, observational, real-world study from May 2012 to May 2023 at four Chinese tertiary medical centers. Patients were divided into statin and control groups based on pre-admission statin use. The primary outcome was favorable outcome at 30 days, defined as a modified Rankin Scale (mRS) score of 0–2. Propensity score matching (PSM) was applied to balance baseline characteristics. The trial was registered with Chinese Clinical Trial Registry (ChiCTR2300079305).
Out of 1,431 patients, 821 met the inclusion criteria (statin group: 367; control group: 454). After PSM, each group comprised 220 patients. Pre-admission statin was associated with a higher likelihood of favorable outcome at 30 days (before PSM: odds ratio [OR] 3.67, 95% confidence interval [CI] 2.46–5.47, p
Pre-admission statin therapy was associated with improved prognosis at 30 days in patients with aneurysmal SAH, however this benefit could not extend to 90 days. The effect of statin appeared to vary according to baseline LDL-C levels and alcohol consumption. Further multicenter, international randomized controlled trials are warranted to confirm these findings.
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