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Aneurysmal Subarachnoid Hemorrhage

Part of Intracranial Hemorrhage

9 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Aneurysmal Subarachnoid Hemorrhage

7 trials tracked for Aneurysmal Subarachnoid Hemorrhage: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 34 citations.

7Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 3 Other / NA 1
  1. Phase 3 Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrowing of the Blood Vessels (Vasospasm) in the Brain, Caused by Bleeding Onto the Surface of the Brain Completed · 34 cited
  2. Phase 4 Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage Completed · 20 cited
  3. Phase 4 Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm Completed
  4. Phase 2 Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial Completed
  5. Phase 2 The Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage Completed
  6. Phase 2 Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM) Completed
Show 1 more trials
  1. N/A Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Aneurysmal Subarachnoid Hemorrhage: what the trials found

Clinical trials have evaluated several pharmacological interventions for aneurysmal subarachnoid hemorrhage (aSAH). Clazosentan was assessed regarding its impact on clinical deterioration due to delayed cerebral ischemia (DCI) and clinically relevant cerebral infarction; results showed no statistically significant difference between groups in either outcome (p=0.7338 and p=0.177, respectively) 3. Furthermore, the modified Rankin Scale (mRS) at week 12 did not show a statistically significant difference between treatment arms (p=0.1983) 3.

Acetazolamide was evaluated for its effects on cerebral hemodynamics, resulting in a 20.722% relative percent change in cerebral blood flow and increases in brain imaging maps for both the left hemisphere (19.785%) and right hemisphere (21.659%) 2.

Gabapentin was investigated for pain management; however, no statistically significant differences were found between groups regarding average numeric pain scores (p=0.7), average narcotic consumption (p=0.79), or pain control satisfaction (p=0.66) 1.

Recent results — preliminary, needs further review

  • Tiopronin was evaluated in a phase 2 trial where mRS scores at discharge, 3 months, and 12 months were recorded (N=60) 4.

For the clinician treating this condition

  • Clazosentan did not demonstrate significant differences in DCI-related deterioration or cerebral infarction rates compared to control groups 3.
  • Acetazolamide is associated with measurable increases in cerebral blood flow and changes in bilateral hemisphere brain imaging maps 2.
  • Gabapentin showed no statistically significant impact on pain scores, narcotic requirements, or patient satisfaction in the studied cohort 1.

AI synthesis of 4 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Intracranial Hemorrhage

Related studies from across the Intracranial Hemorrhage family.

Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus
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Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus Blood Product Removal Shows Lower Risks for Preterm Infants
This meta-analysis of 256 preterm infants with intraventricular hemorrhage and posthemorrhagic hydrocephalus found that blood product remova…
A meta-analysis suggests blood product removal may lower mortality and infection rates in preterm infants with specific brain conditions.
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
Neurology Meta-analysis
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke Atrial Fibrillation Linked to Stroke Risk After Brain Bleed
This systematic review and meta-analysis of 198,289 adults with intracerebral hemorrhage (ICH) identifies an annual recurrence rate of 2.1% …
A large review of over 198,000 patients shows a significant link between atrial fibrillation and stroke risk following an intracerebral hemo…
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH
Neurology Sys. Review
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH AI tools may better predict bleeding in the brain
This systematic review evaluates the evolution of imaging-based prediction methods for hematoma expansion in patients with acute intracerebr…
A new review shows AI methods may predict brain bleed expansion better than traditional scans, but hurdles remain.
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear
Neurology Sys. Review
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear Remote Imaging Lesions May Predict Outcomes for Brain Bleeds
This systematic review examines remote diffusion-weighted imaging (R-DWI) lesions in patients with spontaneous intracerebral hemorrhage. The…
New imaging techniques can identify remote brain tissue damage in patients with a brain bleed, which may help doctors predict patient outcom…
Individualized shunt pressure titration may slow autologous skull graft resorption in patients with hydrocephalus
Orthopedics & Sports Medicine Sys. Review
Individualized shunt pressure titration may slow autologous skull graft resorption in patients with hydrocephalus Adjusting Shunt Pressure May Slow Skull Graft Resorption
This case report and literature review describes a patient with intracerebral hemorrhage, cerebral arteriovenous malformation, and communica…
A case study shows that tailoring shunt pressure can help manage skull graft resorption in patients with specific types of brain injuries.
MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage
Neurology Meta-analysis
MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage Minimally Invasive Surgery Shows Better Outcomes for Brain Bleeds
This network meta-analysis of 18 randomized controlled trials evaluated surgical interventions for spontaneous intracerebral hemorrhage. MIP…
New research suggests minimally invasive and endoscopic surgeries may offer better functional recovery for patients with brain bleeds compar…
Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage
Neurology RCT
Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage Single pill with three blood pressure drugs cuts stroke risk after brain bleed
This multinational randomized controlled trial enrolled 1670 patients with a history of intracerebral hemorrhage and baseline systolic blood…
A single pill combining three low-dose blood pressure drugs reduced recurrent stroke risk by 39% in people who had a brain bleed.
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men
Emergency Medicine RCT
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men Trial finds women with impaired consciousness have different outcomes
This post hoc analysis of a multicenter randomized trial included 364 critically ill adults requiring electroencephalography. Women showed h…
A trial of critically ill adults found women with impaired consciousness had higher rates of brain bleeding and seizures but similar surviva…
IVIG and platelet transfusions managed immune thrombocytopenia in a very preterm infant with intraventricular hemorrhage
Pediatrics Sys. Review
IVIG and platelet transfusions managed immune thrombocytopenia in a very preterm infant with intraventricular hemorrhage A preterm baby with low platelets improved after IVIG and transfusions
This case report and literature review describes management of immune thrombocytopenia in a very preterm male infant born to a mother with i…
A very preterm male infant born to a mother with immune thrombocytopenia improved after receiving intravenous immunoglobulin and platelet tr…
Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke
Neurology RCT
Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke Even small bleeds after minor stroke raise death risk in this trial analysis
This secondary analysis of a multicenter randomized controlled trial evaluated 865 patients with minor ischemic stroke within 12 hours of sy…
A look at trial data shows that small bleeds after minor stroke are linked to higher death rates, even if they do not worsen long-term funct…
Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients
Neurology RCT
Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients High small-vessel disease scores raise stroke risk in hemorrhage-prone patients
This post hoc analysis of a prospective, multicenter randomized controlled trial in 1,454 hemorrhage-prone patients found that higher modifi…
Patients with high small-vessel disease scores face higher risks of ischemic stroke and heart events, even if they have a history of bleedin…
Narrative review proposes integrative monitoring framework for intracerebral hemorrhage
Neurology Sys. Review
Narrative review proposes integrative monitoring framework for intracerebral hemorrhage New monitoring tools may help tailor iron treatments for brain bleeding
This narrative review critiques current monitoring strategies for intracerebral hemorrhage and proposes a multidimensional integrative frame…
Current ways to track brain bleeding often miss the complex chemical changes happening inside. A review suggests better tools could help doc…

Questions about Aneurysmal Subarachnoid Hemorrhage

Does where my aneurysm is located change my chances of dying from aneurysmal subarachnoid hemorrhage?

A large meta-analysis found no significant difference in mortality between anterior and posterior circulation aneurysm locations after aSAH.

Full answer →
Will my aneurysm location affect my survival after aneurysmal subarachnoid hemorrhage?

A large meta-analysis found no significant difference in survival between anterior and posterior circulation aneurysm locations after subarachnoid hemorrhage.

Full answer →
Can a five-variable model predict my 90-day outcome after aneurysmal subarachnoid hemorrhage?

Yes, a five-variable model using age, pre-morbid mRS, WFNS grade, modified Fisher grade, and ICH on CT can predict 90-day outcomes after aSAH with good accuracy (AUC 0.868-0.917).

Full answer →