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Progressive muscle relaxation significantly reduces fatigue and pain in patients with Multiple SclerosisProgressive Muscle Relaxation May Reduce Fatigue and Pain in MS

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Key Takeaway
Consider progressive muscle relaxation as a complementary nonpharmacological intervention to reduce fatigue and pain in MS.

This meta-analysis evaluated the impact of progressive muscle relaxation (PMR) on symptoms and well-being in 671 adults with Multiple Sclerosis. The study focused on primary outcomes including fatigue, sleep, depression, stress, pain, and various measures of overall well-being such as quality of life and self-efficacy.

The analysis found that PMR led to a significant reduction in fatigue (p =.004) and a significant reduction in pain (p <.0001). Additionally, the authors reported consistent positive effects regarding overall well-being. These findings suggest that PMR may be an effective nonpharmacological technique for managing specific symptoms and improving quality of life in this population.

Limitations included the exclusion of some studies due to methodological differences. While the results suggest PMR can be useful as a complementary nursing care intervention, the evidence is based on an association reported in a meta-analysis of multiple studies. Clinical application should consider the nonpharmacological nature of the intervention.

How this fits prior evidence

This finding addresses a gap in nonpharmacological management for Multiple Sclerosis symptoms. While prior evidence highlights that Virtual Reality Rehabilitation may improve gait, mobility, and quality of life, this meta-analysis specifically addresses the efficacy of progressive muscle relaxation in reducing fatigue and pain. It complements existing evidence regarding improvements in quality of life for patients with MS.

A review of several studies involving 671 adults with Multiple Sclerosis looked at the effects of progressive muscle relaxation (PMR). This technique involves tensing and relaxing different muscle groups to help the body relax. The researchers looked at how PMR affected common symptoms like fatigue, pain, and sleep, as well as overall quality of life.

The analysis showed that people who practiced PMR experienced a significant reduction in both fatigue and pain. The results also showed consistent positive effects on overall well-being. This includes improvements in areas like daily activities, self-esteem, and self-efficacy. These findings suggest that PMR can be a helpful tool for managing the daily challenges of living with MS.

Because this was a meta-analysis of existing studies, the results show a link between the practice and improved symptoms rather than a direct cause. Some studies were excluded due to different methods, which means the evidence is not complete. While PMR is a non-drug technique, you should talk with your healthcare team to see if it is a good addition to your current care plan.

What this means for you:
Progressive muscle relaxation may help people with MS reduce fatigue and pain while improving overall well-being.

Common questions

What is progressive muscle relaxation?

Progressive muscle relaxation is a non-drug technique where you tense and then relax different muscle groups. In this study of 671 adults with Multiple Sclerosis, it was used to see if it could help manage symptoms like fatigue and pain while improving overall well-being.

Can this technique help with MS fatigue?

Yes, the study found a significant reduction in fatigue for those with Multiple Sclerosis who used progressive muscle relaxation. The data showed a p-value of .004 for this specific improvement, suggesting it may be a helpful tool for managing daily energy levels.

Does it help with chronic pain in MS?

The study showed a significant reduction in pain for people with Multiple Sclerosis using this method. The results were statistically significant with a p-value of less than .0001, indicating that it may be an effective way to manage physical discomfort.

Study Details

Study typeMeta analysis
Sample sizen = 671
EvidenceLevel 1
Follow-up216.0 mo
PublishedNov 2026
View Original Abstract ↓
PURPOSE: Multiple sclerosis (MS) is a chronic neurological disorder with diverse symptoms impairing daily life and quality of life. Progressive muscle relaxation (PMR) is a nonpharmacological technique to reduce symptoms and enhance well-being. This study evaluated the effects of PMR on MS-related symptoms (fatigue, sleep, depression, stress, pain) and overall well-being (quality of life, daily activities, self-esteem, self-efficacy). DESIGN: The study was designed as a systematic review and meta-analysis. METHODS: Studies including adults (≥18 years) with MS who received PMR were reviewed (August 1, 2024-August 31, 2024). Literature searches were conducted in English and Turkish across EBSCO, PubMed, Web of Science, Embase, Scopus, Cochrane CENTRAL, TR Dizin, DergiPark, and YÖK Thesis. Data unsuitable for meta-analysis were narratively synthesized, standardized mean differences were calculated ( p <.05), and the review was registered in PROSPERO (CRD42024597051). RESULTS: From 282 records, 10 studies with 671 participants were included. PMR showed consistent positive effects on symptoms and overall well-being in individuals with MS, with significant reductions in fatigue ( p = .004) and pain ( p < .0001). Some studies were not included in the meta-analysis due to methodological differences. CLINICAL RELEVANCE TO THE PRACTICE OF REHABILITATION NURSING: PMR can be effective in reducing fatigue and pain, and enhancing overall well-beingfor individuals with MS. CONCLUSIONS: PMR appears effective in reducing fatigue and pain, enhancing overall well-being, and can be useful as complementary nursing care for individuals with MS.
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