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Erector spinae plane block reduces morphine consumption and extends analgesia duration in breast cancer surgeryNerve Block May Reduce Pain and Opioid Use in Breast Surgery

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Key Takeaway
Consider ESPB to potentially reduce morphine consumption and extend analgesia in breast cancer surgery, but note low certainty.

This meta-analysis evaluates the impact of uni-level erector spinae plane block (ESPB) compared to standard procedures involving general anesthesia and opioids for breast cancer surgery patients. The analysis synthesized data on pain scores, analgesia duration, and morphine consumption.

Key findings indicate that ESPB significantly reduced VAS pain scores and decreased NRS pain scores at 24 h. Analgesia duration was longer with ESPB (MD 7.03; 95%CI 4.92, 9.14; P < 0.0001). Additionally, postoperative morphine consumption was lower with ESPB (MD -5.77; 95% CI, -7.89, -3.65; P < 0.0001). Secondary outcomes included decreased intraoperative fentanyl and decreased postoperative tramadol consumption. No significant differences were found for NRS scores at 12 h.

The authors note several limitations, including high heterogeneity and the fact that most included studies had a high or unclear risk of bias. Consequently, the certainty of these results is low. Clinical application of ESPB to reduce opioid consumption and postoperative pain scores should be approached with caution.

How this fits prior evidence

This meta-analysis extends the evidence regarding the use of erector spinae plane block (ESPB) for postoperative pain management. It specifically builds upon the finding that ESPB significantly reduces postoperative pain scores and opioid consumption in bariatric surgery patients, now applying this finding to the context of breast cancer surgery. While the current meta-analysis shows a reduction in morphine consumption (MD -5.77) and longer analgesia duration (MD 7.03), the evidence is limited by high heterogeneity and low certainty.

Researchers looked at how a specific nerve block, called an erector spinae plane block (ESPB), affects pain and medication use in patients undergoing breast cancer surgery. They compared this technique to the standard method of using general anesthesia and opioids.

The analysis found that patients who received the ESPB had lower pain scores and a longer duration of pain relief. These patients also required less morphine and tramadol after their surgery. However, the study did not find a significant difference in pain scores specifically at the 12-hour mark.

It is important to note that the evidence for this finding is not very strong. The researchers noted that the studies they reviewed had a high risk of bias and a lot of variation. Because of these factors, the results should be viewed with caution. Patients should talk to their surgical team to see if this technique is appropriate for their specific needs.

What this means for you:
An ESPB nerve block may lower pain and opioid use after breast surgery, but evidence is currently limited.

Common questions

Can this nerve block reduce the amount of pain medication I need?

The study found that patients who received the erector spinae plane block (ESPB) used less morphine and tramadol after surgery compared to standard care. However, because the study had a low certainty of evidence and high risk of bias, you should discuss your specific pain management plan with your doctor.

How does this treatment compare to standard surgery care?

The ESPB nerve block was compared to the standard procedure of general anesthesia and opioids. The results showed that the nerve block led to lower pain scores and a longer duration of pain relief, though it did not show a significant difference in pain scores at the 12-hour mark.

Is this a proven way to manage pain after breast surgery?

While the study showed a link between the nerve block and lower pain scores, the evidence is not yet strong enough to be certain. The researchers noted high heterogeneity and a high risk of bias in the studies reviewed, so it is not yet a standard change in practice.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
BACKGROUND: Surgery remains the cornerstone of management in breast cancer patients. Regional anesthesia techniques, such as the erector spinae plane block (ESPB), have emerged as adjuncts to standard therapy for postoperative pain control. METHODS: Studies comparing ESPB and standard procedure of general anesthesia and opioids were included. Primary outcomes were postoperative pain scores, analgesia duration, and postoperative morphine consumption. RESULTS: VAS pain scores were significantly reduced with the ESPB group. Similarly, longer analgesia duration (MD 7.03, 95%CI 4.92, 9.14, P < 0.0001), and lower postoperative morphine consumption (MD -5.77; 95% CI, -7.89, -3.65; P < 0.0001) were observed in the ESPB group. NRS pain scores at 24 h, intraoperative fentanyl, and postoperative tramadol consumption also decreased with ESPB. No significant differences were observed for NRS scores at 12 h. However, heterogeneity was high and most of the included studies had high or unclear risk of bias. CONCLUSION: ESPB may reduce opioid consumption and postoperative pain scores compared to the control groups. However, these results should be taken cautiously, due to the high risk of bias among the included studies and low certainty.
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