Modified pectoral plane block (PECS II) provides longer analgesia duration and lower morphine use
New nerve block technique may reduce morphine use after mastectomy
This meta-analysis of 790 patients undergoing modified radical mastectomy found that the PECS II technique provided significantly longer ana…
A new nerve block method could provide longer pain relief and lower morphine needs for patients undergoing breast cancer surgery.
Intranasal naloxone reverses opioid-induced respiratory depression in opioid-naive and daily users within 2 to 17 minutes
Narcan nasal spray reverses opioid breathing depression quickly
This prospective crossover trial enrolled 12 opioid-naive individuals and 18 daily opioid users.
Narcan nasal spray restored breathing within minutes in opioid users, but some had delayed or incomplete recovery.
Meta-analysis of ketamine versus other analgosedatives in critically ill children receiving invasive mechanical ventilation
Ketamine cuts opioid use in ventilated kids
This systematic review and meta-analysis evaluated continuous ketamine infusion compared with other analgosedatives in critically ill childr…
A new analysis suggests ketamine could help reduce opioid use in children on breathing machines, offering a safer path to pain control in in…
Esketamine vs fentanyl for pediatric tonsillectomy pain shows comparable FLACC scores
Esketamine and fentanyl ease kids' tonsil pain equally after surgery
This randomized controlled trial in 54 children scheduled for tonsillectomy compared esketamine 0.5 mg·kg to fentanyl 4 μg·kg at induction.
For kids getting tonsils out, esketamine and fentanyl control pain just as well, but esketamine keeps blood pressure steadier during surgery…
Systematic Review Analyzes Pharmacometric Modeling of Opioids and Fentanyl in Pregnancy
Opioid Dosing in Pregnancy May Need a Rethink
This systematic review evaluates pharmacometric modeling approaches, including population pharmacokinetic and physiologically based pharmaco…
Pregnancy speeds up how the body processes pain meds, meaning standard doses may leave moms in pain or risk baby safety.
Meta-analysis shows dexmedetomidine lowers mean arterial pressure compared to midazolam-fentanyl in surgical patients
A Calmer Sedative May Make Surgery Safer for Patients
This systematic review and meta-analysis evaluated 259 surgical patients receiving either dexmedetomidine or midazolam-fentanyl during intra…
A newer sedative keeps patients calmer with steadier vitals and fewer breathing problems than the older standard combination during surgery.
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants
Back Pain That Won't Go Away
This retrospective cross-sectional study characterized clinical presentation, comorbidities, and treatments in 1105 participants with physic…
A massive online community of chronic pain patients helped researchers finally map the symptoms and treatments for the often missed conditio…
Alfentanil-remimazolam shortens emergence time versus fentanyl-remimazolam in first-trimester abortion anesthesia
A Gentler Anesthesia Lets You Wake Up Faster After Surgery
A randomized trial in 120 patients undergoing first-trimester surgical abortion found that alfentanil-remimazolam led to shorter emergence a…
For common outpatient surgeries, a tweak in anesthesia drugs could mean a smoother, faster wake-up with fewer involuntary movements.
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate
Study describes use of IV sedation for dental care in patients with special needs
A retrospective cohort study of 212 special health care needs patients (mean age 11.1 years) undergoing outpatient IV sedation for dental pr…
Over 2,200 dental procedures were safely performed on children with autism and Down syndrome using IV sedation at a Venezuelan clinic, with …