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Home › Medications › fentanyl

fentanyl

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of fentanyl

74 trials tracked of fentanyl: 45 in phase 3 or 4 and 10 with published results. The most-cited published study has 116 citations.

74Trials tracked
45Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 31 Phase 3 14 Phase 2 12 Phase 1 4 Other / NA 13
  1. Phase 3 Pain Reduction With Intranasal Medications for Extremity Injuries Completed · 116 cited
  2. Phase 4 Single Injection Adductor Canal Block vs Catheter for Total Knee Arthroplasty Completed · 78 cited
  3. Phase 4 The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY) Completed · 67 cited
  4. Phase 4 Comparison of Meperidine and Fentanyl on Pain Scale and QOL in Brachytherapy Completed · 43 cited
  5. Phase 4 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection Completed · 30 cited
  6. Phase 4 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Completed · 21 cited
Show 44 more trials
  1. Phase 4 Remifentanil and Glycemic Response in Cardiac Surgery Completed · 19 cited
  2. Phase 4 Determining the Prognostic Value of Continuous Intrathecal Infusion Completed · 15 cited
  3. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  4. Phase 4 Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Completed · 2 cited
  5. Phase 4 Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis Completed
  6. Phase 4 Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring Completed
  7. Phase 4 Open Label Crossover Study Pharmacokinetics (PK) Study in Healthy Volunteers Receiving Various Forms of Fentanyl Completed
  8. Phase 4 Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain Completed
  9. Phase 4 Comparison of PIEB vs CEI for Labor Analgesia Completed
  10. Phase 4 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Completed
  11. Phase 4 Labetalol and Esmolol: Vital Signs and Post Operative Pain Management Completed
  12. Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure Completed
  13. Phase 4 Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery. Completed
  14. Phase 4 Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels. Completed
  15. Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
  16. Phase 4 Intranasal Fentanyl as an Analgesic for Cystoscopic Procedures Completed
  17. Phase 4 Dexmedetomidine vs Fentanyl for BMT Completed
  18. Phase 4 The Effect of Choice of Intraoperative Opioid on Postoperative Pain Completed
  19. Phase 4 An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain Completed
  20. Phase 4 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty Completed
  21. Phase 4 Airway Responses During Desflurane Anesthesia Via a Laryngeal Mask Airway: Effects of Fentanyl Pretreatment Completed
  22. Phase 4 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed
  23. Phase 4 RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder. Completed
  24. Phase 4 Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation Completed
  25. Phase 4 Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy Completed
  26. Phase 4 Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management Completed
  27. Phase 3 Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy Completed
  28. Phase 3 Safety and Efficacy Study of Fentanyl Buccal Tablet Use in the Emergency Department for Isolated Extremity Injury Completed
  29. Phase 3 Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants Completed
  30. Phase 3 Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy Completed
  31. Phase 3 Dexmedetomidine to Treat Bariatric Surgery-associated Pain Completed
  32. Phase 3 Open-Label, Safety, and Efficacy Study of Dexmedetomidine in Preterm Subjects Ages ≥28 Weeks to <36 Weeks Gestational Age Completed
  33. Phase 3 Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects Completed
  34. Phase 3 An Efficacy and Safety Study of Fentanyl (JNS020QD) in Participants With Cancer Pain Completed
  35. Phase 3 An Efficacy and Safety Study of Fentanyl in Participants With Chronic Pain Completed
  36. Phase 3 Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement Completed
  37. Phase 3 Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery Completed
  38. Phase 3 A Confirmatory Study of Fentanyl in Participants With Osteoarthritis or Low Back Pain Completed
  39. Phase 3 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed
  40. Phase 2 Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain Completed
  41. Phase 2 Evaluation of DEX-IN During Outpatient Procedures Completed
  42. Phase 2 Fentanyl Sublingual Spray for the Treatment of Moderate to Severe Post-Operative Pain Completed
  43. Phase 2 IN Sub-Dissociative Ketamine vs IN Fentanyl Completed
  44. Phase 2 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl Completed

Showing the 50 most-cited and recently-updated of 74 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Opioid flexion phenotype is a descriptive term for sustained forward flexion in fentanyl exposure
Neurology Sys. Review
Opioid flexion phenotype is a descriptive term for sustained forward flexion in fentanyl exposure Opioid Flexion Phenotype Helps Identify Potential Toxicity in Overdoses
This narrative review describes the opioid flexion phenotype in patients with fentanyl exposure. The authors clarify that this posture is a …
A specific forward-leaning posture in opioid use may signal potential toxicity and help first responders prioritize life-saving ventilation.
Frontiers Sep 10, 2026
Ketamine/midazolam reduces maximum intraprocedural pain by 1.4 points compared to fentanyl/midazolam
Radiology & Imaging RCT
Ketamine/midazolam reduces maximum intraprocedural pain by 1.4 points compared to fentanyl/midazolam Ketamine and midazolam reduce pain during lung and bone biopsies
This randomized clinical trial of 260 adults undergoing image-guided lung or bone biopsy or abscess drainage found that ketamine/midazolam s…
A new trial shows that a ketamine and midazolam mix can lower pain and improve oxygen levels during painful lung or bone procedures.
Sep 8, 2026
Erector spinae plane block provides comparable analgesic efficacy to paravertebral plane block in breast cancer surgery
Oncology Meta-analysis
Erector spinae plane block provides comparable analgesic efficacy to paravertebral plane block in breast cancer surgery Comparing Two Different Nerve Blocks for Pain Relief During Breast Cancer Surgery
This meta-analysis of 1527 patients undergoing breast cancer surgeries compared erector spinae plane block (ESPB) to paravertebral plane blo…
Doctors compared two types of nerve blocks to see which method provided better pain relief and faster surgery times for breast cancer patien…
Aug 24, 2026
Preoperative pregabalin 150 mg cuts pain and opioid use after laparoscopic cholecystectomy
Drug Pipeline Meta-analysis
Preoperative pregabalin 150 mg cuts pain and opioid use after laparoscopic cholecystectomy Pregabalin May Reduce Pain After Gallbladder Surgery
This meta-analysis of randomized trials found that a single 150 mg preoperative dose of pregabalin significantly reduced 24-hour postoperati…
A single dose of pregabalin before surgery may lower pain scores and reduce the need for opioid medications after gallbladder removal.
medRxiv Aug 23, 2026
Serratus anterior plane block reduces postoperative nausea and opioid consumption after surgery under general anesthesia
Anesthesiology & Pain Medicine Meta-analysis
Serratus anterior plane block reduces postoperative nausea and opioid consumption after surgery under general anesthesia Serratus Anterior Block May Reduce Nausea After Surgery
This meta-analysis of 1,651 patients found that serratus anterior plane block (SAPB) reduced the incidence of postoperative nausea (RD = -0.…
A new nerve block technique may help reduce nausea and vomiting after surgery while lowering the amount of pain medication patients need.
Frontiers Aug 16, 2026
Ofloxacin shows superior relative efficacy for pain control after photorefractive keratectomy
Rheumatology Meta-analysis
Ofloxacin shows superior relative efficacy for pain control after photorefractive keratectomy Topical and systemic drugs help manage pain after eye surgery
This systematic review and network meta-analysis of 2,797 patients evaluated pharmacological strategies for post-photorefractive keratectomy…
New data identifies specific medications that rank highest for managing patient pain following photorefractive keratectomy eye procedures.
Frontiers Aug 11, 2026
Tegileridine 0.5 mg reduces fentanyl-induced cough incidence from 28.7% to 11.1%
Rheumatology RCT
Tegileridine 0.5 mg reduces fentanyl-induced cough incidence from 28.7% to 11.1% Tegileridine reduces coughing during surgery after fentanyl injection
This randomized controlled trial of 216 adults undergoing elective surgery found that tegileridine 0.5 mg significantly reduced the incidenc…
A new treatment may help patients avoid painful and uncomfortable coughing immediately after receiving pain medication before surgery.
Frontiers Jul 19, 2026
Peripheral nerve blocks reduce 24-hour morphine use by 16.20 mg in kidney transplant recipients
Anesthesiology & Pain Medicine Meta-analysis
Peripheral nerve blocks reduce 24-hour morphine use by 16.20 mg in kidney transplant recipients Nerve blocks cut opioid use after kidney transplant surgery
This meta-analysis of adult kidney transplant recipients found that peripheral nerve blocks (PNBs) reduced 24-hour morphine consumption by 1…
A new analysis shows nerve blocks reduce opioid use by 16 mg after kidney transplant, with no reported side effects.
Jun 16, 2026
Modified pectoral plane block (PECS II) provides longer analgesia duration and lower morphine use
Oncology Meta-analysis
Modified pectoral plane block (PECS II) provides longer analgesia duration and lower morphine use New nerve block technique may reduce morphine use after mastectomy
This meta-analysis of 790 patients undergoing modified radical mastectomy found that the PECS II technique provided significantly longer ana…
A new nerve block method could provide longer pain relief and lower morphine needs for patients undergoing breast cancer surgery.
Jun 8, 2026
Intranasal naloxone reverses opioid-induced respiratory depression in opioid-naive and daily users within 2 to 17 minutes
Anesthesiology & Pain Medicine RCT
Intranasal naloxone reverses opioid-induced respiratory depression in opioid-naive and daily users within 2 to 17 minutes Narcan nasal spray reverses opioid breathing depression quickly
This prospective crossover trial enrolled 12 opioid-naive individuals and 18 daily opioid users.
Narcan nasal spray restored breathing within minutes in opioid users, but some had delayed or incomplete recovery.
May 1, 2026
Meta-analysis of ketamine versus other analgosedatives in critically ill children receiving invasive mechanical ventilation
Pediatrics Meta-analysis
Meta-analysis of ketamine versus other analgosedatives in critically ill children receiving invasive mechanical ventilation Ketamine cuts opioid use in ventilated kids
This systematic review and meta-analysis evaluated continuous ketamine infusion compared with other analgosedatives in critically ill childr…
A new analysis suggests ketamine could help reduce opioid use in children on breathing machines, offering a safer path to pain control in in…
Apr 27, 2026
Esketamine vs fentanyl for pediatric tonsillectomy pain shows comparable FLACC scores
Pediatrics RCT
Esketamine vs fentanyl for pediatric tonsillectomy pain shows comparable FLACC scores Esketamine and fentanyl ease kids' tonsil pain equally after surgery
This randomized controlled trial in 54 children scheduled for tonsillectomy compared esketamine 0.5 mg·kg to fentanyl 4 μg·kg at induction.
For kids getting tonsils out, esketamine and fentanyl control pain just as well, but esketamine keeps blood pressure steadier during surgery…
Apr 23, 2026

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