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Home › Conditions › Osteosarcoma

Osteosarcoma

Part of Epithelioid Sarcoma

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Osteosarcoma

19 trials tracked for Osteosarcoma: 1 in phase 3 or 4.

19Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 1 Phase 2 15 Phase 1 2 Other / NA 1
  1. Phase 3 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed
  2. Phase 2 A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma Completed
  3. Phase 2 A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors Completed
  4. Phase 2 A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma Completed
  5. Phase 2 Phase II Study of Chemotherapy and Pamidronate for the Treatment of Newly Diagnosed Osteosarcoma Completed
  6. Phase 2 Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Completed
Show 13 more trials
  1. Phase 2 Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) Completed
  2. Phase 2 Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma Completed
  3. Phase 2 Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy Completed
  4. Phase 2 A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma Completed
  5. Phase 2 A Study of Pemetrexed in Children With Recurrent Cancer Completed
  6. Phase 2 Study of Lenvatinib in Children and Adolescents With Refractory or Relapsed Solid Malignancies and Young Adults With Osteosarcoma Completed
  7. Phase 2 M6620 (VX-970) in Selected Solid Tumors Completed
  8. Phase 2 Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX. Completed
  9. Phase 2 A Phase II Study of Oral Cyclophosphamide and Sirolimus (OCR) in Advanced Sarcoma Completed
  10. Phase 2 Chemotherapy for Patients With Osteosarcoma Completed
  11. Phase 1 Open-label Leucovorin Pharmacokinetic Study in Patients Receiving High Dose Methotrexate With or Without Voraxaze Completed
  12. Phase 1 Metronomic Chemotherapy in Patients With Advanced Solid Tumor With Bone Metastasis and Advanced Pretreated Osteosarcoma Completed
  13. N/A Molecular-Guided Therapy for Childhood Cancer Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Immunotherapy and metabolic-targeted drug combination shows promise for osteosarcoma treatment
Allergy & Immunology Sys. Review
Immunotherapy and metabolic-targeted drug combination shows promise for osteosarcoma treatment Combining immunotherapy with metabolic drugs may help treat osteosarcoma better
This narrative review explores combining immunotherapy with metabolic-targeted drugs for osteosarcoma, focusing on metabolic reprogramming i…
Doctors are looking at mixing immune system treatments with drugs that change how cells use energy. This new approach could help fight back …
Frontiers Jun 5, 2026
Systematic Review of Macrophage Polarization in Osteosarcoma Immunotherapy
Allergy & Immunology Meta-analysis
Systematic Review of Macrophage Polarization in Osteosarcoma Immunotherapy Macrophage Polarization Offers New Target for Osteosarcoma
This systematic review explores the role of targeting and regulating macrophage polarization in osteosarcoma. It synthesizes preclinical evi…
A new review suggests steering immune cells could lead to better treatments for children with bone cancer.
Frontiers May 25, 2026
Systematic review of preclinical CBD effects in canine cancers
Cardiology Meta-analysis
Systematic review of preclinical CBD effects in canine cancers Lab tests suggest CBD may help treat cancer in dogs
This is a systematic review of preclinical studies on cannabidiol for canine cancers. It synthesizes evidence of antiproliferative and proap…
Lab tests suggest CBD may help treat cancer in dogs by slowing growth and triggering cell death, though human use remains unproven.
Frontiers May 22, 2026
Machine learning model predicts delayed methotrexate clearance in pediatric osteosarcoma patients
Pediatrics Cohort
Machine learning model predicts delayed methotrexate clearance in pediatric osteosarcoma patients Study develops model to predict delayed drug clearance in pediatric bone cancer
A retrospective cohort study of 181 pediatric osteosarcoma patients treated with high-dose methotrexate developed a web-based prediction mod…
A new computer model predicts which children with bone cancer face delayed drug clearance, helping doctors monitor treatment risks before co…
Frontiers Apr 6, 2026
Phase II trial opens for Viscum album extract adjuvant therapy in relapsed osteosarcoma
Oncology Phase II
Phase II trial opens for Viscum album extract adjuvant therapy in relapsed osteosarcoma Early study explores mistletoe extract as additional treatment for relapsed bone cancer in young people
A Phase II trial is now open to evaluate adjuvant Viscum album extract (Iscador® P) in children and AYAs with relapsed, resectable osteosarc…
A pilot study found that adding mistletoe extract after surgery helped 55% of young people with relapsed bone cancer stay alive without dise…
Apr 2, 2026