MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
MRI Radiomics Help Predict TERTp Mutation in Glioma Patients
Meta-analysis of 14 studies shows MRI radiomics predicts TERTp mutation in glioma with AUC 0.79; combined models improve accuracy to 0.82.
New analysis shows MRI-based radiomics can help predict specific genetic mutations in glioma, potentially aiding early diagnosis and treatme…
Reduced-dose craniospinal radiation and smaller volume boost for medulloblastoma patients
Trial Shows Reduced Radiation May Help Children With Medulloblastoma
This randomized phase 3 trial evaluated reduced-dose craniospinal radiation (18.00 Gy) and a smaller volume boost in children aged 3 to 7 wi…
A large clinical trial looked at whether reducing radiation doses for children with medulloblastoma can maintain safety and effectiveness.
Dysregulation of the TOX/TCF-1 axis and IDH-mutation driven silencing drive cytotoxic failure in glioblastoma
Single-cell atlas reveals how glioblastoma disables immune cells
This systematic review examines the immunological landscape of glioblastoma, specifically focusing on cytotoxic lymphocyte dysfunction. The …
A systematic review maps the cellular and molecular mechanisms behind immune failure in glioblastoma, identifying key targets for future the…
NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
Brain scan technique helps tell gliomas from metastases
This meta-analysis evaluates the use of Neurite orientation dispersion and density imaging (NODDI) to distinguish gliomas from brain metasta…
A new imaging method may help doctors distinguish between gliomas and brain metastases without invasive biopsy.
Deep learning models for glioma segmentation achieve high whole tumor accuracy with DSC 0.860
New AI tools show high accuracy for mapping brain tumors before surgery
This systematic review and meta-analysis of 36 deep learning models for preoperative glioma segmentation found high whole tumor segmentation…
AI models mapped brain tumors with high accuracy, but performance varied. Training on specific datasets helped, yet no single factor fully e…
Meta-analysis links high platelet ratios to worse overall survival in adult glioblastoma patients
High blood cell ratios linked to shorter life in glioblastoma patients
This meta-analysis reviews data from 2609 patients with WHO grade 4 diffuse astrocytoma to evaluate platelet indices. High platelet: lymphoc…
High blood cell ratios are linked to shorter life in glioblastoma patients. This analysis of over 5,000 adults shows how simple blood tests …
Systematic review of preclinical CBD effects in canine cancers
Lab tests suggest CBD may help treat cancer in dogs
This is a systematic review of preclinical studies on cannabidiol for canine cancers. It synthesizes evidence of antiproliferative and proap…
Lab tests suggest CBD may help treat cancer in dogs by slowing growth and triggering cell death, though human use remains unproven.
Systematic review explores metabolic-immune axis in glioma progression and resistance
Metabolic-immune link in glioma opens new treatment avenues
This systematic review synthesizes evidence on the metabolic-immune interplay in glioma. It finds that metabolic reprogramming and immune mi…
A systematic review reveals how metabolic reprogramming and immune evasion work together in glioma, pointing to new targets for therapy.
Systematic Review Links Neural Circuit Disturbances to Glioma Symptoms and Survival
Brain tumor growth linked to disrupted neural circuits
This systematic review synthesizes evidence that circuit-level disturbances in the neural microenvironment correspond with glioma-related ep…
A new review shows that glioma disrupts brain circuits, linking seizures, mood changes, and survival. Could rewiring the brain help treat tu…
Case report suggests second primary glioblastoma in ALK-positive lung adenocarcinoma patient treated with ensartinib and lorlatinib
A single patient case warns doctors to check for second cancers when tumors act strangely
This case report describes a 63-year-old female with ALK-positive lung adenocarcinoma who received ensartinib, lorlatinib, and stereotactic …
A 63-year-old woman with lung cancer developed a new brain tumor that was not a metastasis. Doctors must carefully examine unusual tumor gro…
Review of glioma organoid models for mechanistic discovery and therapy development
Finally Lab-Grown Brain Models Could Speed Up Glioma Treatments
This narrative review summarizes glioma organoid model systems for studying tumor-neural interactions. It concludes these models provide a f…
• Tiny lab-grown brains mimic real tumor behavior better than old methods • Kids and adults fighting deadly brain cancers like glioblastoma …
Narrative Review Explores Immune Checkpoint Inhibition in Pediatric Medulloblastoma
New immune targets offer hope for children with recurrent brain tumors
This narrative review discusses the potential of immune checkpoint inhibition via direct antibody targeting in pediatric medulloblastoma. Th…
A new generation of immune drugs is being tested to help children whose brain tumors have returned after standard treatment
Research across Cancer
Related studies from across the Cancer family.
Preoperative model predicts functional outcomes after glioma resection using clinical and MRI variables
AI predicts brain tumor recovery before surgery begins
This retrospective cohort study of 552 adults undergoing first resection of supratentorial contrast-enhancing glioma evaluated a preoperativ…
A new AI tool uses MRI scans to predict how well brain tumor patients recover after surgery and helps doctors plan care better.
Case report reviews capmatinib off-label use in two patients with radiation-induced MET-fusion glioma
Capmatinib Shows Promise Against Rare Brain Tumors
This case report with literature review describes off-label capmatinib use in two patients with radiation-induced gliomas harboring MET fusi…
A drug used for lung cancer is now helping some children with rare, deadly brain tumors live longer, even when standard treatments fail.
Recurrence patterns in high-grade glioma after standard chemoradiotherapy: a retrospective review
Why tumors grow back inside the radiation beam, not just at the edges
This retrospective single-center review of 41 patients with high-grade glioma found that central recurrence was the most common pattern (36.…
New data shows brain tumors often return in the middle of the radiation zone, suggesting biology, not just targeting errors, drives failure.
GSC-associated gene signature predicts survival in adult and pediatric high-grade glioma patients
New Brain Tumor Test Predicts Survival More Accurately
This cohort study evaluated a GSC-associated gene signature involving the FAM86B1/FAM86B2 axis in adult and pediatric high-grade glioma pati…
A new model uses specific genes to predict how long patients might live with aggressive brain tumors.
Unsupervised clustering of glioma RNAseq data shows diagnostic and prognostic potential
AI-powered analysis reveals hidden brain tumor subtypes with survival links
This unsupervised clustering analysis of public TCGA glioma RNAseq data (n=692) found high diagnostic concordance and prognostic separation.
A new AI method sorted brain tumors into groups that matched clinical diagnoses 91% of the time and uncovered subtypes tied to survival.
Review of STING agonists for high-grade and diffuse midline glioma discusses systemic toxicity and delivery constraints
New Brain Drug Target Could Wake Up the Immune System
This narrative review examines the potential of STING agonists, cyclic dinucleotides, and related compounds for treating high-grade glioma a…
A new brain drug target aims to wake up the immune system's defenses against dangerous, hard-to-treat tumors that hide from the body's natur…
CyberKnife-SRT for brainstem glioma shows median overall survival of 20.9 months in retrospective cohort
CyberKnife May Help Rare Brain Tumor Patients Live Longer
This retrospective cohort study of 54 patients with brainstem glioma treated with CyberKnife-SRT found a median overall survival of 20.9 mon…
A new radiation technique called CyberKnife helps rare brainstem glioma patients live longer by sparing healthy tissue while treating the tu…
Locoregional CAR T-cell delivery reduces severe adverse events in high-grade glioma patients
Could a new way to deliver brain cancer therapy make it safer and more effective?
A meta-analysis of 14 clinical trials involving 194 high-grade glioma patients found locoregional CAR T-cell delivery was associated with re…
Delivering brain cancer therapy directly to the tumor instead of through the bloodstream cuts severe side effects by more than 60% and shows…
Questions about Glioma
How does the immune system interact with Glioma cells in the brain?
Glioma cells suppress immune attack by recruiting regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages, while also triggering ferroptosis via CD8+ T cell signals.
Full answer →Can RNA data help doctors predict the outcome of my Glioma diagnosis?
Yes, RNA data can help predict glioma outcomes by revealing molecular subtypes linked to survival, as shown in studies using unsupervised clustering of RNAseq data.
Full answer →Does having a high mutation burden help Glioma patients live longer on treatment?
No, high mutation burden does not help glioma patients live longer on treatment; it is linked to poor survival and low immunotherapy response.
Full answer →Can AI models predict how well my Glioma will respond to radiotherapy?
Yes, AI models that combine radiomics, dosiomics, and clinical data can predict radiotherapy response in glioma, but they are not yet standard clinical tools.
Full answer →All Glioma Articles
- MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
- Reduced-dose craniospinal radiation and smaller volume boost for medulloblastoma patients
- Dysregulation of the TOX/TCF-1 axis and IDH-mutation driven silencing drive cytotoxic failure in glioblastoma
- NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
- Deep learning models for glioma segmentation achieve high whole tumor accuracy with DSC 0.860
- Meta-analysis links high platelet ratios to worse overall survival in adult glioblastoma patients
- Systematic review of preclinical CBD effects in canine cancers
- Systematic review explores metabolic-immune axis in glioma progression and resistance
- Systematic Review Links Neural Circuit Disturbances to Glioma Symptoms and Survival
- Case report suggests second primary glioblastoma in ALK-positive lung adenocarcinoma patient treated with ensartinib and lorlatinib
- Review of glioma organoid models for mechanistic discovery and therapy development
- Narrative Review Explores Immune Checkpoint Inhibition in Pediatric Medulloblastoma
- Tumor treating fields plus chemotherapy improved survival outcomes for newly diagnosed and recurrent glioblastoma patients in this meta-analysis
- Narrative review covers hepatocellular carcinoma, colorectal cancer, glioblastoma, breast cancer, pancreatic cancer, and non-small cell lung cancer
- Meta-analysis of preclinical models shows enhanced outcomes for focused ultrasound gene therapy in glioblastoma
- Genomically tailored multiagent regimen shows limited efficacy in recurrent glioblastoma
- Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
- High tumour mutation burden improves overall survival in solid tumours treated with immune checkpoint inhibitors
- Meta-analysis of bevacizumab therapy in recurrent glioblastoma multiforme shows associations with improved outcomes
- Observational study identifies four immune subtypes in newly-diagnosed glioma grades 2-4 among 354 patients
- Preoperative model predicts functional outcomes after glioma resection using clinical and MRI variables
- Case report reviews capmatinib off-label use in two patients with radiation-induced MET-fusion glioma
- Specialized palliative care intervention enrollment patterns in a glioblastoma randomized controlled trial sub-analysis
- Narrative review suggests multi-omics AI models improve glioma radiotherapy response prediction over single-modality approaches
- LP-184 Alone and With Spironolactone in Recurrent Glioblastoma: Phase 1a Results
- GSC-associated gene signature predicts survival in adult and pediatric high-grade glioma patients
- Meta-analysis of TKI combinations in glioblastoma shows improved PFS and ORR with mixed safety signals
- Systematic review and meta-analysis of intra-arterial cerebral infusion for glioma patients
- Unsupervised clustering of glioma RNAseq data shows diagnostic and prognostic potential
- ERS-related DNA methylation profiles stratify glioblastoma patients into four subtypes with 92.4% prediction accuracy
- Radiomics from edema zone predicts progression-free survival in postoperative glioma patients
- Retrospective cohort of 443 glioma patients analyzed under successive WHO classifications from 2007 to 2021
- Narrative review examines multimodal AI for glioma using neuroimaging and hematologic biomarkers
- Review of STING agonists for high-grade and diffuse midline glioma discusses systemic toxicity and delivery constraints
- Narrative review explores CSF1R inhibitor potential in pediatric medulloblastoma precision immunotherapy
- Narrative review on ferroptosis-targeting strategies for glioblastoma modulation
- Phase 1/2 trial shows RT + bevacizumab + olaptesed pegol extends PFS and OS in unmethylated GBM
- Systematic review evaluates Treg depletion and reprogramming strategies for glioblastoma in adults
- PINK1 expression quantified by IHC in adults with newly diagnosed IDH-wild type glioblastoma multiforme
- DOC1021 vaccine with SOC showed favorable 12-month OS in newly-diagnosed glioblastoma patients
- Multi-omics integration identifies candidate genes and cell-type-specific effects in glioma
- PARPi combinations show no significant clinical improvement in adult patients with glioblastoma
- Radiomics models predict IDH mutation status and survival in glioma patients across discovery and validation cohorts
- Deep learning QTMnet shows potential for glioma grading versus traditional 2CXM model
- Case report describes intracranial WHO Grade II ependymoma with rare lipomatous metaplasia
- Bibliometric analysis identifies 100 most-cited articles on proton therapy for glioma
- Bibliometric analysis maps 4.3-fold rise in elderly glioma research, highlights MGMT focus