This study examined how aging affects the buildup of advanced glycation end-products, or AGEs, in skeletal muscle. Forty-one healthy adults between 55 and 70 years old participated in the research. They received either a berry extract or a placebo for 30 days, followed by 12 weeks of supervised resistance and high-intensity interval training.
The main finding showed that AGE signals were naturally higher in type I muscle fibers and in the surrounding tissue compared to other areas. However, neither the exercise program nor the berry supplements changed the amount of AGEs found in the muscle.
The researchers also checked for links between AGE levels and factors like sex, age, or inflammation markers, finding no connections. While the study was safe with no reported side effects, these results apply only to this specific group of healthy older adults over a short period.
Readers should understand that this study does not prove that exercise or berries reduce AGEs in muscle. The evidence is limited to one small trial and does not mean these actions are ineffective for other health goals.