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TORCH seroprevalence 32.5% in Malaysia; CMV highest, screening urgedTORCH infections found in 32.5% of Malaysian pregnant women and infants

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Key Takeaway
Consider screening pregnant women in Malaysia for TORCH infections, especially CMV, given the high seroprevalence.

This meta-analysis synthesizes 19 reports to estimate the seroprevalence of TORCH infections (toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and syphilis) among pregnant women and infants in Malaysia. The overall pooled seroprevalence was 32.5% (95% CI [16.6-53.8%]; p < 0.001), indicating substantial exposure to these pathogens in this population.

Subgroup analyses revealed a seroprevalence of 27.7% among pregnant women and 35.1% among infants. Cytomegalovirus (CMV) showed the highest seroprevalence, with 93.2% in pregnant women and 95.9% in infants. In contrast, the lowest seroprevalence was 1.1% among pregnant women and 4% among infants, though the specific agent was not explicitly named in the abstract.

The authors emphasize the high burden of TORCH infections and the importance of screening pregnant women to prevent vertical transmission. However, the review does not report limitations, funding sources, or conflict of interest declarations, and the specific agent with the lowest prevalence is not identified, which limits the precision of the findings.

Clinicians should interpret these results with caution due to the wide confidence interval and the lack of reported heterogeneity or risk of bias assessments. The findings underscore the need for targeted screening and preventive strategies in Malaysia, but further research is needed to clarify regional variations and clinical outcomes.

How this fits prior evidence

This meta-analysis extends prior coverage by quantifying the overall TORCH seroprevalence in Malaysia, complementing earlier findings on CMV's role in immune aging and the influence of HLA alleles on CMV-specific T-cell responses. It also contrasts with the 4CMenB vaccine trial that showed no reduction in syphilis infections, suggesting that seroprevalence data alone may not capture the impact of preventive interventions. The high CMV seroprevalence aligns with prior evidence linking CMV to immune dysregulation, reinforcing the need for screening and monitoring.

A new analysis of 19 studies from Malaysia suggests that many pregnant women and infants there have been exposed to a group of infections known as TORCH. These include toxoplasmosis, rubella, cytomegalovirus (CMV), herpes simplex, and syphilis. The overall rate of exposure, called seroprevalence, was 32.5% across both groups. That means about one in three had antibodies, showing past or current infection.

When the researchers looked at pregnant women and infants separately, they found slightly different rates. Among pregnant women, the seroprevalence was 27.7%. Among infants, it was 35.1%. The most common infection was CMV, with rates of 93.2% in pregnant women and 95.9% in infants. The lowest rates were much smaller, at 1.1% in pregnant women and 4% in infants, though the specific infection was not named in the summary.

This is a meta-analysis, which combines results from multiple studies. That makes the findings more reliable than any single study, but it still has limits. The analysis did not report on safety concerns or side effects, and it did not specify which infection had the lowest rates. Also, the studies were all from Malaysia, so the results may not apply to other countries.

The main takeaway is that TORCH infections are common in this population, especially CMV. This highlights the importance of screening pregnant women to prevent passing these infections to their babies. However, this does not mean that every exposure leads to harm. If you are pregnant or planning to be, talk to your doctor about whether screening is right for you.

What this means for you:
TORCH infections are common in Malaysian pregnant women and infants, especially CMV, but screening decisions should be made with a doctor.

Common questions

What are TORCH infections?

TORCH stands for toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and syphilis. These are infections that can be passed from a pregnant woman to her baby, potentially causing health problems. The meta-analysis looked at how common these infections are in Malaysia.

How common are TORCH infections in Malaysia?

The meta-analysis found that 32.5% of pregnant women and infants in Malaysia have been exposed to TORCH infections. Specifically, 27.7% of pregnant women and 35.1% of infants had antibodies. Cytomegalovirus was the most common, with rates above 93%.

Should I get screened for TORCH infections during pregnancy?

The study highlights that TORCH infections are common, but it does not give specific screening advice. If you are pregnant or planning to be, talk to your doctor about whether screening is appropriate for you. They can consider your individual risk factors and recommend the best steps.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJan 2026
View Original Abstract ↓
BACKGROUND: Toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and syphilis (TORCH) infections in infants and pregnant women are a cause for concern. However, the true prevalence of the infections among these populations in Malaysia is unknown. METHODOLOGY: This study represents the first systematic review and meta-analysis to assess the seroprevalence of TORCH agents in pregnant women and infants in Malaysia. Data from scientific articles published until November 2025 were analyzed. RESULTS: A total of 19 reports on the seroprevalence of infection by TORCH agents in Malaysia were analyzed. The overall seroprevalence was 32.5% (95% CI [16.6-53.8%]; = 99.4%; < 0.001) among pregnant women and infants in Malaysia. Based on the target population, 27.7% and 35.1% seroprevalence were found in pregnant women and infants, respectively. Among the TORCH agent types, Cytomegalovirus (CMV) in pregnant women and infants demonstrated the highest seroprevalence (93.2% and 95.9%, respectively), while () seroprevalence was the lowest among pregnant women (1.1%) and infants (4%). CONCLUSIONS: This study reveals a high seroprevalence of TORCH infection and underscores the importance of adequately screening pregnant women to prevent potential vertical transmission to the neonate.
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