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Home › Conditions › Cytomegalovirus

Cytomegalovirus

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cytomegalovirus

10 trials tracked for Cytomegalovirus: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 172 citations.

10Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 1 Phase 3 4 Phase 2 4 Other / NA 1
  1. Phase 4 CMV Antiviral Prevention Strategies in D+R-Liver Transplants ("CAPSIL") Completed · 172 cited
  2. Phase 3 Extension of Letermovir (LET) From Day 100 to Day 200 Post-transplant for the Prevention of Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant (HSCT) Participants (MK-8228-040) Completed · 108 cited
  3. Phase 3 MK-8228 (Letermovir) in the Prevention of Human Cytomegalovirus (CMV) Infection and Disease in Adult Japanese Kidney Transplant Recipients (MK-8228-042) Completed · 4 cited
  4. Phase 3 A Study of Letermovir (MK-8228) to Evaluate Efficacy and Safety for Prevention of Cytomegalovirus Infection in Chinese Hematopoietic Stem Cell Transplant Recipients (MK-8228-045) Completed
  5. Phase 3 Short-Term vs. Long-Term Valganciclovir Therapy for Symptomatic Congenital CMV Infections Completed
  6. Phase 2 Study of CMX001 to Prevent/Control Cytomegalovirus Infection in R+ Hematopoietic Stem Cell Transplant Recipients Completed
Show 4 more trials
  1. Phase 2 Primary Transplant Donor Derived CMVpp65 Specific T-cells for The Treatment of CMV Infection or Persistent CMV Viremia After Allogeneic Hematopoietic Stem Cell Transplantation Completed
  2. Phase 2 Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus (CMV) Vaccine mRNA-1647 in Healthy Adults Completed
  3. Phase 2 Valganciclovir Therapy in Infants and Children With Congenital CMV Infection and Hearing Loss Completed
  4. N/A Dried Blood Spot Testing of CMV Detection in HCT Recipients Completed

Showing the 10 most-cited and recently-updated of 10 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Cytomegalovirus: what the trials found

Valganciclovir has been shown to significantly reduce the incidence of Cytomegalovirus (CMV) disease compared to control groups (p=0.0396) 2. However, its use did not result in a statistically significant difference in all-cause mortality (p=0.19) or the incidence of allograft rejection (p=0.60) 2.

Letermovir has demonstrated efficacy in reducing clinically significant CMV infection post-transplant; specifically, 2.8% of patients received Letermovir compared to 18.9% in the control group from week 14 through week 28 (p=0.0005) 3. In other studies, Letermovir was associated with a 32% incidence of clinically significant CMV infection up to week 24 post-transplant 5.

Clinical trials evaluating Valganciclovir in the context of hearing assessments showed no statistically significant differences in hearing outcomes at 6, 12, or 24 months compared to control groups 6. Similarly, a separate study on Valganciclovir for hearing did not find statistically significant differences in improved/unchanged hearing versus worsened hearing at month 6 (p=0.859) or when assessing the best ear specifically (p=0.7068) 8.

Letermovir administration was associated with high rates of adverse events (AEs), reported between 90.9% and 99.2% across different study cohorts, though discontinuation due to AE was low or zero in specific trials [4, 5].

Recent results — preliminary, needs further review

  • mRNA-1647 demonstrated high rates of significant increases (≥2-fold, ≥3-fold, and ≥4-fold) in neutralizing antibodies against both epithelial cell infection and fibroblast infection in both seropositive and seronegative populations 1.

For the clinician treating this condition

  • Valganciclovir is effective in reducing the incidence of CMV disease but does not show a statistically significant impact on all-cause mortality or allograft rejection rates.
  • Letermovir significantly reduces the rate of clinically significant CMV infection post-transplant compared to standard controls.
  • mRNA-1647 induces robust neutralizing antibody responses against both epithelial and fibroblast infections in both seropositive and seronegitive patients.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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