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Decision rule based on clinical symptoms and procalcitonin reduces antibiotic use in children with feverNew decision rule reduces unnecessary antibiotics for children with fever

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Key Takeaway
Consider using a decision rule including procalcitonin to reduce unnecessary antibiotic use in children with fever.

The study evaluated the impact of a specific decision rule on antibiotic prescribing for children presenting with fever without source in emergency departments. The decision rule integrated several factors, including the child's age, clinical symptoms, urine analysis, and point-of-care procalcitonin measurements, to guide treatment decisions. This was compared against standard care protocols in a large cohort of infants and young children.

Results indicated that children managed under the decision rule were less likely to receive antibiotics within a set follow-up period compared to those managed under usual care. Importantly, the authors observed no significant differences in morbidity or mortality between the two groups. This suggests that the decision rule may effectively identify children who do not require immediate antibiotic intervention while maintaining safety.

While the study design supports a causal inference for reduced antibiotic use, the clinical application depends on the consistent integration of procalcitonin and clinical markers. The findings suggest that such a decision rule could be a useful tool for clinicians to manage antibiotic stewardship in pediatric emergency departments. Clinicians may consider this approach to reduce unnecessary prescriptions while maintaining high standards of care for febrile children.

When a child runs a fever, it can be stressful for parents and difficult for doctors to know exactly when to prescribe antibiotics. Many children have fevers caused by viruses, which do not require antibiotics. This study looked at how a specific decision rule could help doctors make better choices in emergency rooms.

Researchers followed 4,882 children between the ages of 6 days and 36 months who had a fever but no clear source. They compared a new decision rule, which used age, symptoms, urine tests, and a specific protein measurement called procalcitonin, against standard care. The results showed that the decision rule significantly lowered the number of children who received antibiotics within 15 days. In the standard care group, 38% of children received antibiotics, while only 26.2% received them under the new rule.

Importantly, the study found no difference in illness or death between the two groups. This suggests that the new rule can help cut down on unnecessary medicine while keeping children safe. While the study is a strong piece of evidence, it is always important to talk to a healthcare provider about the best treatment for a child's specific symptoms.

What this means for you:
A new decision rule safely reduces the number of unnecessary antibiotics for young children with a fever.

Common questions

Does this new method keep children safe?

Yes. The study of 4,882 children found no significant difference in illness or death between the group using the new decision rule and the group receiving standard care. This suggests the rule can safely reduce the number of antibiotics given to children with a fever.

How many children received antibiotics in the study?

In the group receiving usual care, 927 children (38.0%) received antibiotics within 15 days. In the group using the new decision rule, only 641 children (26.2%) received antibiotics during that same period.

What factors are included in the new decision rule?

The decision rule is based on four main factors: the age of the child, their clinical symptoms, an analysis of their urine, and a point-of-care measurement of a protein called procalcitonin.

Study Details

Study typeRct
EvidenceLevel 2
Follow-up36.0 mo
PublishedSep 2026
View Original Abstract ↓
OBJECTIVE: To evaluate whether a point-of-care decision rule could safely reduce antibiotic prescriptions in children presenting with fever without source in emergency departments. DESIGN: Open cluster randomised clinical trial (registered on ClinicalTrials.gov). SETTING: Twenty-five European paediatric emergency departments participated from November 2018 to October 2021. PATIENTS: Children aged 6 days to 36 months presenting with acute fever without source. INTERVENTIONS: During the first year, all centres (or clusters) followed their usual care protocols. In the second year, centres were randomised 1:1 to either continue usual care or to adopt the decision rule based on age, clinical symptoms, urine analysis and point-of-care procalcitonin measurements. In the third year, all centres applied the decision rule. MAIN OUTCOMES AND MEASURES: The primary outcome was antibiotic exposure within 15 days. Secondary outcomes included morbidity and mortality assessed at day 15. RESULTS: Among 4882 children (median age: 3 months, IQR 1-14), 2440 were in the usual care group and 2442 in the decision rule group. Serious bacterial infections occurred in 766 (15.7%) children, and invasive bacterial infections in 67 (1.4%). In the intention-to-treat analysis, 927 children (38.0%) received antibiotics within 15 days in the usual care group, compared with 641 (26.2%) in the decision rule group (OR 0.57; 95% CI 0.43 to 0.75; p<0.001). Morbidity and mortality rates were similar between groups (OR 0.83; 95% CI 0.57 to 1.22; p=0.34). CONCLUSIONS: The decision rule safely reduced unnecessary antibiotic use in young children with fever without source in emergency departments. TRIAL REGISTRATION NUMBER: NCT03607162.
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