Mode
Text Size
Log in / Sign up

Systematic review links e-cigarette flavors to inflammation and cellular damage in animal modelsE-cigarette flavors may increase nicotine use and health risks

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note the association between flavored e-cigarettes and increased inflammation, respiratory symptoms, and DNA damage.

This systematic review evaluates the effects of specific e-cigarette flavors, including fruity, mentolog/mint, and sweet varieties, across animal models and human populations. The scope of the synthesis covers impacts on nicotine consumption, respiratory health, and cellular integrity.

In animal models, the review finds that these flavors increase nicotine consumption and preference, alongside the activation of reward circuits. The evidence also links these flavors to increased inflammation, cellular damage, and cardiovascular changes. In humans, the authors report associations between these flavors and respiratory symptoms, reduced lung function, and DNA damage in oral cells.

A limitation of this review is the exclusion of in vitro studies. Additionally, the authors excluded studies with conflicts of interest related to the tobacco industry. While the findings suggest these products may pose health risks comparable to combustible cigarettes, the review reports associations in humans and effects in animal models rather than direct causality.

Clinicians should note the potential for flavor-driven nicotine dependence and the associated risks to respiratory and cardiovascular systems.

If you reach for an e-cigarette because you love the taste of fruit or mint, you might be making it harder to quit. New evidence suggests that flavors like sweet, fruity, and menthol are not just about taste. They actually increase how much nicotine people consume and how much they prefer these products.

This review of studies in both humans and animals shows that these flavors are linked to serious health issues. In humans, these flavored products are associated with respiratory symptoms, reduced lung function, and even DNA damage in oral cells. In animal models, the flavors were linked to inflammation, cellular damage, and changes in the cardiovascular system.

Beyond the physical damage, these flavors also appear to activate reward circuits in the brain. This makes the habit more addictive. While these findings show a strong link between flavors and harm, it is important to note that the human data shows associations rather than direct cause and effect. However, the evidence suggests these flavored products can be as harmful to health as traditional cigarettes.

What this means for you:
Flavored e-cigarettes may increase nicotine addiction and cause lung, heart, and cellular damage.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
ObjectivesThis systematic review evaluated the scientific evidence on the effects of flavors in electronic cigarettes in animal models and their impact on human health, aiming to understand the potential risks associated with their use.MethodsA PubMed search was conducted using MeSH terms such as “e-cigarettes AND flavor AND nicotine AND e-liquid AND cytotoxicity AND cellular damage and health AND adolescent AND young people.” We selected original studies that evaluated tissue damage, inflammation, oxidative stress, and DNA damage in animal models, as well as health outcomes in humans. In vitro studies, studies with conflicts of interest related to the tobacco industry, and studies that did not meet our objectives were excluded.ResultsFruity, menthol/mint, and sweet flavors increase nicotine consumption and preference for e-cigarettes in animal models and are also linked to inflammation, cellular damage, and cardiovascular changes. In humans, these flavors have been associated with respiratory symptoms, reduced lung function, and DNA damage in oral cells. Neurological effects, such as activation of reward circuits, have also been observed.ConclusionThe evidence available to date suggests that these products can be as harmful to health as combustible cigarettes.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD420261346170.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.