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Home › Medications › nicotine

nicotine

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of nicotine

27 trials tracked of nicotine: 7 in phase 3 or 4 and 1 with published results. The most-cited published study has 25 citations.

27Trials tracked
7Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 4 Phase 3 3 Phase 2 2 Phase 1 9 Other / NA 9
  1. Phase 4 Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study) Completed · 25 cited
  2. Phase 4 Nicotine as an Adjuvant Analgesic for Third Molar Surgery Completed
  3. Phase 4 Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms Completed
  4. Phase 4 Nicotine Patch for Marijuana Withdrawal Completed
  5. Phase 3 Vaping THC From Electronic Cigarettes Completed
  6. Phase 3 Efficacy and Safety Study of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation Completed
Show 21 more trials
  1. Phase 3 Nicotine Mouth Film for Craving Relief. Completed
  2. Phase 2 Pharmacokinetic Study of 4 mg Nicotine Lozenge. Completed
  3. Phase 2 Provoked Craving Relief Study by NRT Completed
  4. Phase 1 Effects of E-Cigarette Flavors on Adults TCORS 2.0 Completed
  5. Phase 1 Behavioral Pharmacology of Cannabis and Nicotine Completed
  6. Phase 1 Effects of Commonly Used Medications on Mood and Choice Completed
  7. Phase 1 Nicotine Reinforcement and Aversion in Young Adult Light Smokers Completed
  8. Phase 1 Nicotine's Potential Abuse With Menthol Completed
  9. Phase 1 Oral Tolerability Of Two Nicotine Dosage Forms Completed
  10. Phase 1 Nicotine Patch Pretreatment for Smoking Cessation in PTSD Completed
  11. Phase 1 Effects of E-cigarette Flavors on Youth TCORS 2.0 Completed
  12. Phase 1 A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers Completed
  13. N/A The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users Completed
  14. N/A Nicotinic Modulation of the Default Network Completed
  15. N/A Nicotine and Behavior in Adult ADHD Completed
  16. N/A Effect of the Electronic Cigarette on Withdrawal Symptoms Completed
  17. N/A Group Therapy for Nicotine Dependence: Mindfulness and Smoking Completed
  18. N/A Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study Completed
  19. N/A Smoking Cessation After Hospitalization for a Cardiopulmonary Illness Completed
  20. N/A Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking Completed
  21. N/A A Smoking Cessation Trial in HIV-infected Patients in South Africa Completed

Showing the 27 most-cited and recently-updated of 27 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Nicotine electronic cigarettes increase quit rates compared to nicotine replacement therapy and behavioral support
Oncology Sys. Review
Nicotine electronic cigarettes increase quit rates compared to nicotine replacement therapy and behavioral support Nicotine electronic cigarettes show higher quit rates than traditional methods
This systematic review of 80 RCTs involving 29,861 participants found that nicotine electronic cigarettes (EC) significantly increased quit …
New data shows people using nicotine-containing electronic cigarettes are more likely to quit smoking compared to those using standard repla…
Cochrane Aug 27, 2026
Systematic review links e-cigarette flavors to inflammation and cellular damage in animal models
Primary Care & Family Medicine Meta-analysis
Systematic review links e-cigarette flavors to inflammation and cellular damage in animal models E-cigarette flavors may increase nicotine use and health risks
This systematic review examines the health impacts of fruity, menthol/mint, and sweet e-cigarette flavors using animal models and human data…
Sweet, fruity, and minty e-cigarette flavors are linked to higher nicotine use and serious respiratory and cellular damage.
Frontiers Apr 30, 2026
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality
Cardiology Cohort
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality Adding Prescription Meds to Nicotine Patches Lowers Heart Death Risk
This retrospective cohort study of 8,574 propensity-matched pairs found that adding bupropion or varenicline to NRT after ACS was associated…
Heart attack survivors who quit smoking with extra prescription help live longer.
medRxiv Apr 24, 2026