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Antipsychotic use persists in hospitalized dementia patients despite intervention

Antipsychotic use persists in hospitalized dementia patients despite intervention
Photo by Annie Spratt / Unsplash
Key Takeaway
Recognize that antipsychotic use persists in hospitalized dementia patients; this intervention did not demonstrate a reduction.

This study is a secondary analysis of data from a cluster-randomized trial (RCT) evaluating Function Focused Care for Acute Care Using the Evidence Integration Triangle (FFC-AC-EIT) versus Education Only in 455 hospitalized older adults living with dementia across 12 nursing homes in two states. The primary outcome was antipsychotic use at admission, discharge, and 1 month post discharge. Results showed a statistically significant difference between groups over time (Pillai's Trace = 0.05, p = 0.001). In the intervention group, antipsychotic use was 15% at admission, 23% at discharge, and 18% at 1 month; in the control group, use was 20% at admission, 20% at discharge, and 21% at 1 month. The intervention group showed an increase then decrease, while the control group remained stable. Safety outcomes (adverse events, serious adverse events, discontinuations, tolerability) were not reported. Key limitations include the secondary data analysis design and no evidence to support the value of FFC-AC-EIT in decreasing antipsychotic use. This analysis confirms continued antipsychotic use during and after hospitalization, highlighting the need for interventions to reduce use. However, no causal inference can be drawn, and the clinical relevance of the statistical difference is uncertain.

Study Details

Study typeRct
EvidenceLevel 2
Follow-up1.0 mo
PublishedMay 2026
View Original Abstract ↓
Given the persistent use of antipsychotics during hospitalization and continued use post discharge, there is a need to consider alternative treatment options. The purpose of this study was to evaluate the use of antipsychotics in a sample of hospitalized older adults living with dementia and determine if exposure to Function Focused Care resulted in a decrease in antipsychotic use between admission, discharge, and 1 month post hospitalization. This was a secondary data analysis using data from the study Testing the Effectiveness of the Function Focused Care for Acute Care Study Using the Evidence Integration Triangle (FFC-AC-EIT). A total of 455 residents from 12 nursing homes in two states were included in the study. Sites were randomized to FFC-AC-EIT versus Education Only. The mean age of the participants was 82 years (Standard deviation [] = 8.5) and the majority was female (63%), White older adults (65%), married (36%), with high school or more education (81%), and moderate to severe cognitive impairment based on a Saint Louis University Mental Status Exam score of 7.5 ( = 6.0). Overall, on admission, 17% were on an antipsychotic medication, at discharge, this increased to 21%, and at 1 month, it decreased to 19%. The repeated-measure analysis showed there was a significant difference in antipsychotic use between treatment groups over time (Pillai's Trace of .05,  = 8.9,  = .001). The intervention group increased in usage from 15% on admission to 23% at discharge and decreased to 18% at 1-month post discharge. Conversely, the control group remained essentially the same over time at 20% on admission and discharge and 21% at 1-month post discharge. The findings from this study confirm that there continues to be use of antipsychotics during hospital admissions, and individuals are still discharged on these medications and continued on these medications over time. There was no evidence to support the value of our FFC-AC-EIT in terms of decreasing the use of antipsychotics over time. Future research is needed to develop interventions focused on decreasing the use of antipsychotics.
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