Antipsychotic use persists in hospitalized dementia patients despite intervention
This study is a secondary analysis of data from a cluster-randomized trial (RCT) evaluating Function Focused Care for Acute Care Using the Evidence Integration Triangle (FFC-AC-EIT) versus Education Only in 455 hospitalized older adults living with dementia across 12 nursing homes in two states. The primary outcome was antipsychotic use at admission, discharge, and 1 month post discharge. Results showed a statistically significant difference between groups over time (Pillai's Trace = 0.05, p = 0.001). In the intervention group, antipsychotic use was 15% at admission, 23% at discharge, and 18% at 1 month; in the control group, use was 20% at admission, 20% at discharge, and 21% at 1 month. The intervention group showed an increase then decrease, while the control group remained stable. Safety outcomes (adverse events, serious adverse events, discontinuations, tolerability) were not reported. Key limitations include the secondary data analysis design and no evidence to support the value of FFC-AC-EIT in decreasing antipsychotic use. This analysis confirms continued antipsychotic use during and after hospitalization, highlighting the need for interventions to reduce use. However, no causal inference can be drawn, and the clinical relevance of the statistical difference is uncertain.