Drug-induced osteoporosis mechanisms and gut microbiota links remain largely unresolved for most medication classes
Many common medicines might change gut bacteria and affect bone strength in older adults
This narrative review examines the association between medications such as glucocorticoids and aromatase inhibitors and gut microbiota alter…
Some drugs like antidepressants and seizure medicines can alter gut bacteria. Scientists are still studying if these changes hurt bones or c…
Systematic review on genetic factors in treatment-resistant schizophrenia
Genetic factors linked to treatment-resistant schizophrenia in European ancestry
This systematic review synthesizes genetic findings in treatment-resistant schizophrenia. It finds that common variants explain little liabi…
A review of 102 studies finds genetic markers are connected to treatment-resistant schizophrenia, but common variants explain little risk.
Antipsychotic use persists in hospitalized dementia patients despite intervention
Antipsychotics Stay High Despite New Care Plans
This secondary analysis of an RCT examined antipsychotic use in 455 hospitalized older adults with dementia across 12 nursing homes. The int…
Older adults with dementia often leave the hospital on strong drugs that may not help them feel better at home.
Systematic review and meta-analysis shows increased mortality risk with antipsychotic drugs in dementia patients
Common Dementia Meds Raise Death Risk More Than We Knew
This systematic review and meta-analysis evaluated antipsychotic drug use in people living with dementia. The analysis pooled data from two …
Antipsychotics increase dementia death risk by 32 percent.
Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries
Half of Schizophrenia Patients Take Multiple Drugs at Once
This systematic review and meta-analysis of 17 studies (6,053 individuals) from MENAT/EMRO countries found a pooled prevalence of antipsycho…
New data reveals half of patients with schizophrenia in the Middle East take multiple antipsychotic drugs at once.
Paracingulate sulcus prevalence reduced in patients with catatonia compared to controls
New Brain Scan Clue Points to Catatonia Risk
This hospital-based cohort study compared the paracingulate sulcus (PCS) in 109 patients with catatonia, 323 non-catatonic psychiatric patie…
A new study links specific brain shapes to catatonia, offering hope for better understanding.
ECG abnormalities observed in 45.5% of pediatric patients on antipsychotics in a real-world cohort
Most kids on antipsychotics show normal heart tests
This observational cohort study of 430 children and adolescents found that 45.5% exhibited at least one ECG abnormality during antipsychotic…
Nearly half of children on antipsychotics had minor heart test changes, but dangerous rhythms were absent, suggesting monitoring may be targ…
Antipsychotic exposure shows time-dependent associations with vocational recovery in schizophrenia cohort
Do antipsychotics help people with schizophrenia get back to work or school?
A Danish register-based cohort study of 65,630 individuals with incident schizophrenia spectrum disorders found antipsychotic exposure was a…
Antipsychotic medication use initially lowers work or school chances for schizophrenia patients but eventually shows a small positive link a…