A review of 18 different studies looked at how certain proteins in the blood relate to mental health. Researchers focused on a specific protein called Neuron-specific enolase, often called NSE. They found that people with Major Depressive Disorder and Poststroke Depression often have abnormally high levels of this protein in their blood.
The study suggests that these elevated levels are closely linked to the risk of developing these types of depression. Because the link is consistent across different studies, it may help doctors identify those at risk earlier. However, the researchers noted that more large-scale clinical studies are needed to confirm how this can be used in everyday medical practice.
It is important to remember that while a link was found, the study does not prove that the protein causes depression. Also, the findings may not apply to every type of depression. This research is currently intended as a potential tool for monitoring and early warning rather than a final diagnostic test.