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Systematic review and meta-analysis of digital technology interventions for cognitive function and mood in older adults

Systematic review and meta-analysis of digital technology interventions for cognitive function and m…
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Key Takeaway
Consider digital technology interventions for older adults with cognitive or mood concerns, noting low-certainty evidence.

This systematic review and meta-analysis assessed the impact of digital technology interventions on cognitive function, depression, anxiety, and loneliness in older adults. The authors synthesized data from a total sample size of 1947 participants to evaluate these outcomes. The study was not an RCT but rather a meta-analysis of existing studies.

The analysis reported significant improvements in cognitive function with a standardized mean difference of 1.04 and a 95% CI of 0.69 to 1.38. The p-value for this outcome was less than 0.001. For depression, significant reductions were observed with an SMD of -0.32 and a 95% CI of -0.51 to 0.14, also with a p-value less than 0.001.

Significant reductions in anxiety were found with an SMD of -0.66 and a 95% CI of -0.90 to -0.43, with a p-value less than 0.001. In contrast, no significant difference was found for loneliness, with an SMD of -0.52 and a 95% CI of -1.05 to 0.00. The p-value for loneliness was 0.05.

Safety data, including adverse events and discontinuations, were not reported. The authors state that low-certainty evidence suggests digital technology interventions may benefit older adults. They conclude that more high-quality studies are needed to further verify the effect of these interventions.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
Identify digital technology interventions designed for older adults and examine their effects on mental health, including cognition, loneliness, depression and anxiety. A systematic search was conducted in seven English databases and four Chinese databases, encompassing the period from inception to 24 June 2025. Meta-analysis was performed by Review Manager 5.4 and Stata 16. The GRADE (Recommendation, Assessment, Development and Evaluation) system was used to assess the reliability of the evidence. A total of 19 randomised controlled trials involving 1947 older adults were included. The results showed that older adults who received the digital technology intervention had significant improvements in cognitive function (SMD: 1.04, 95% CI: 0.69-1.38, p < 0.001) and significant reductions in depression (SMD: -0.32, 95% CI: -0.51 to 0.14, p < 0.001) and anxiety (SMD: -0.66, 95% CI: -0.90 to -0.43, p < 0.001). However, there was no significant difference in terms of alleviating loneliness (SMD: -0.52, 95% CI: -1.05 to 0.00, p = 0.05) of the older adults. Low-certainty evidence suggests that digital technology interventions may benefit older adults. In the future, more high-quality studies are needed to further verify its effect.
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