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Meta-analysis finds high anxiety and depression prevalence in pediatric inflammatory bowel diseaseAnxiety and depression are common in young people with inflammatory bowel disease

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Key Takeaway
Consider routine mental health screening for anxiety and depression in pediatric inflammatory bowel disease.

This is a meta-analysis of studies on anxiety and depression in children and adolescents with inflammatory bowel disease. The authors synthesized pooled prevalence data from 14 studies for anxiety symptoms (1,574 subjects) and 35 studies for depressive symptoms (4,426 subjects).

The main findings are a pooled prevalence of 12% for anxiety symptoms (95% CI: 7%-17%) and 15% for depressive symptoms (95% CI: 11%-19%). For anxiety disorders, the pooled prevalence was 9% (95% CI: 5%-14%) from 6 studies (168,378 subjects), and for depressive disorders, it was 8% (95% CI: 5%-11%) from 7 studies (168,475 subjects). The analysis also reported a significantly higher risk of developing anxiety disorders (HR 1.95) and depressive disorders (HR 1.65).

The authors note that the pooled estimates are based on a random-effects model and that heterogeneity was examined via subgroup and sensitivity analyses. A key limitation is that the source reports association, not causation.

The practice relevance highlighted is that routine mental health screening is essential for early intervention. The findings suggest a substantial burden of psychological comorbidities in this population, but the evidence is observational.

A large review of many studies looked at how often anxiety and depression happen in children and teens with inflammatory bowel disease. The researchers combined results from dozens of studies involving over 189,000 young people. They found that anxiety symptoms affect about 12% of these patients, while anxiety disorders affect about 9%.

For depression, the numbers were similar. About 15% of young people with IBD had depressive symptoms, and about 8% had a depressive disorder. The studies included thousands of subjects, giving a good picture of the problem.

The review also found that having IBD is linked to a higher chance of developing anxiety or depression later. Young people with IBD were about twice as likely to develop an anxiety disorder and about 65% more likely to develop a depressive disorder compared to those without IBD. These findings show a strong connection between gut health and mental health in youth.

Because these mental health issues are common, doctors should screen young IBD patients for anxiety and depression. Early help can make a big difference in their overall health and quality of life. The review did not look at specific treatments, but it highlights the need for mental health support as part of IBD care.

What this means for you:
Young people with IBD have a high rate of anxiety and depression, so regular mental health screening is important.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
BACKGROUND: Anxiety and depression are prevalent comorbidities in patients with inflammatory bowel disease (IBD). However, their prevalence and impact in children and adolescents with IBD remain poorly defined. This meta-analysis aimed (i) to estimate the prevalence of anxiety and depression in this population and (ii) to explore the association between these psychological issues and IBD. METHODS: A thorough search of Embase, Web of Science, and PubMed from inception through February 1, 2025, was conducted. Two authors independently extracted data and assessed study quality. Pooled prevalence estimates, odds ratios (ORs), and hazard ratios (HRs) were calculated using a random-effects model. Subgroup and sensitivity analyses were performed to examine sources of heterogeneity and assess result robustness. RESULTS: The meta-analysis included 48 studies with 189,032 children and adolescents with IBD. Pooled prevalence estimates were as follows: anxiety symptoms (12%; 95% confidence interval [CI]: 7%-17%; k [number of studies] = 14; n [number of subjects] = 1574); anxiety disorders (9%; 95% CI: 5%-14%; k = 6; n = 168,378); depressive symptoms (15%; 95% CI: 11%-19%; k = 35; n = 4426); and depressive disorder (8%; 95% CI: 5%-11%; k = 7; n = 168,475). Pooled HRs indicated a significantly higher risk of developing anxiety and depressive disorders in this population, with HRs of 1.95 and 1.65, respectively. CONCLUSIONS: Children and adolescents with IBD face a substantial burden of anxiety and depression. Routine mental health screening is essential for early intervention and comprehensive management of these comorbidities.
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