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Narrative review suggests suprachoroidal injections may improve vision and reduce edema in diabetic macular edema

Narrative review suggests suprachoroidal injections may improve vision and reduce edema in…
Photo by Diana Polekhina / Unsplash
Key Takeaway
Consider suprachoroidal injections as a potential strategy for optimizing diabetic macular edema management.

This narrative review evaluates the potential role of suprachoroidal space injections as an alternative to conventional intravitreal injections for patients with diabetic macular edema. The scope includes comparing these approaches against standard therapies involving anti-vascular endothelial growth factor agents and corticosteroids.

The authors highlight several potential advantages associated with the suprachoroidal approach. These include improvements in vision, reductions in macular edema, decreased treatment frequency, and lower risks of cataract formation and elevated intraocular pressure. The review notes that these outcomes were observed in the context of the available literature.

Specific numerical data, such as absolute numbers, p-values, or confidence intervals, were not reported in the source material. Similarly, details regarding adverse events, serious adverse events, discontinuations, and overall tolerability were not reported. The review does not provide a specific sample size or follow-up duration. Consequently, the practice relevance focuses on optimizing diabetic macular edema management strategies while acknowledging the current lack of quantitative certainty.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
Diabetic macular edema (DME) is the leading cause of vision loss in patients with diabetes. Conventional therapies like intravitreal injections (IVI) of anti-vascular endothelial growth factor (VEGF) agents and corticosteroids are often limited by the frequent injections and risks of complications. Suprachoroidal space (SCS) injection has emerged as a novel drug delivery technique. It targets eye precisely, resulting in high drug concentration in the posterior segment while reducing exposure to anterior segment tissues—thereby potentially lowering risks of both cataract formation and elevated intraocular pressure. Clinical data shows that SCS injection of triamcinolone acetonide (TA) can significantly improve vision, reduce both macular edema and treatment frequency in DME patients. In this review, we mainly aim to introduce the advantages and clinical evidence of SCS injection, and emphasize its potential role in optimizing DME management strategy.
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