Intravitreal ziv-aflibercept reduces central macular thickness and improves visual acuity in DME and RVO
Trial shows ziv-aflibercept improves vision in macular edema cases
This systematic review and meta-analysis of 5 RCTs and 8 observational studies found that intravitreal ziv-aflibercept significantly reduced…
A new eye treatment called ziv-aflibercept may help reduce swelling and improve vision for patients with specific types of macular edema.
Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications
Review suggests exosomes may help target multiple diabetes complications
This narrative review explores the role of exosomes in diabetic kidney disease, retinopathy, and peripheral neuropathy. It highlights their …
A narrative review suggests exosomes might inform strategies to target multiple diabetes complications together, though clinical standardiza…
Narrative review suggests suprachoroidal injections may improve vision and reduce edema in diabetic macular edema
New eye injection method reduces shots and protects vision for diabetics
This narrative review examines suprachoroidal space injections versus conventional intravitreal therapies for diabetic macular edema. The au…
A new injection technique for diabetic eye disease could spare patients from frequent shots and lower the risk of cataracts while improving …
FDA Approves Pavblu (aflibercept) for Neovascular AMD, RVO, DME, and DR
FDA approves Pavblu to treat several eye conditions that cause vision loss.
The FDA approved Pavblu (aflibercept) for neovascular AMD, macular edema following RVO, DME, and DR. It is a VEGF inhibitor administered by …
The FDA approved Pavblu (aflibercept) for wet age-related macular degeneration, macular edema, diabetic macular edema, and diabetic retinopa…
Systematic review and meta-analysis shows aflibercept biosimilars match reference drug efficacy and safety in AMD and DME
Aflibercept biosimilars match the original drug for eye disease treatment
This systematic review and meta-analysis evaluated aflibercept biosimilars versus reference aflibercept for neovascular age-related macular …
A large review of 4064 patients found that aflibercept biosimilars work just as well as the original drug for two common eye conditions.
Aflibercept 8 mg extended dosing maintains visual gains with fewer injections versus 2 mg every 8 weeks in DME
Aflibercept 8 mg every 16 weeks matches standard dosing for diabetic macular edema
This randomized, double-masked, noninferiority phase 2/3 trial enrolled 658 patients aged ≥ 18 years with center-involved diabetic macular e…
A new trial shows that aflibercept 8 mg every 16 weeks works as well as the standard 2 mg every 8 weeks for diabetic macular edema with fewe…
Systematic review and meta-analysis finds no significant association between diabetic retinopathy and age-related macular degeneration
Diabetic retinopathy and age-related macular degeneration show no significant link
This systematic review and meta-analysis evaluates the association between diabetic retinopathy and age-related macular degeneration.
A meta-analysis found no significant relationship between diabetic retinopathy and age-related macular degeneration, though existing data ha…
Lower vitreous CREG1 levels associated with reduced ranibizumab response in diabetic macular edema
Low CREG1 levels may link to poor treatment response
This retrospective cohort study of 189 patients with diabetic macular edema found that lower vitreous CREG1 levels were associated with non-…
New findings suggest that certain protein levels and blood markers might help identify which patients respond to diabetic macular edema trea…
High LDL-C to HDL-C ratio linked to cardiovascular events in type 2 diabetes with retinopathy
High cholesterol ratio raises heart risk in diabetics
This post hoc analysis of a randomized controlled trial in 5,006 high-risk type 2 diabetes patients with diabetic retinopathy found that a h…
A routine cholesterol test may reveal hidden heart danger in people with diabetes, even when taking cholesterol drugs.
OCT-A metrics show association with diabetic retinopathy status in cross-sectional study
Eye Scan Spots Diabetes Vision Damage Earlier
This cross-sectional study abstract evaluates the association between OCT-A metrics and diabetic retinopathy status in 108 adult eyes.
A fast, painless eye scan can catch diabetes-related vision damage years before symptoms appear, offering a real chance to save sight before…
Systematic Review Finds Chinese and Western Medicine Combination May Improve Diabetic Retinopathy Outcomes
Chinese Medicine Boosts Eye Care for Diabetics
This systematic review and meta-analysis of 1,127 patients with non-proliferative diabetic retinopathy found that combination therapy with C…
Mixing traditional Chinese medicine with standard Western eye care may help diabetics protect their vision and reduce uncomfortable symptoms…
Meta-analysis finds AI screening tools strongly associated with diabetic retinopathy detection
AI tools show strong link to spotting diabetic eye disease
This meta-analysis of observational and diagnostic studies reports a pooled odds ratio of 5.79 (95% CI: 5.22–6.42) for standalone deep learn…
AI screening tools were linked to better detection of diabetic eye disease in a large review of studies, suggesting they could help identify…
Research across Diabetes
Related studies from across the Diabetes family.
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Local antibiotic delivery systems increase healing rates in diabetic foot osteomyelitis compared with control groups in this meta-analysis
Local Antibiotics May Boost Healing in Diabetic Foot Infections
This systematic review and meta-analysis evaluated local antibiotic delivery systems versus control groups for patients with diabetic foot o…
A new analysis suggests local antibiotic delivery may improve healing for diabetic foot bone infections, but more research is needed.
Antibiotic cement achieves 85.2% healing rate in diabetic foot osteomyelitis meta-analysis
Antibiotic cement may help heal diabetic foot infections without major surgery
A systematic review and meta-analysis of 82 patients with diabetic foot osteomyelitis found a weighted healing rate of 85.2% with antibiotic…
A meta-analysis suggests antibiotic-impregnated cement can heal diabetic foot osteomyelitis in most patients, though some still need surgery…
SGLT2 inhibitor use associated with increased diabetic ketoacidosis risk, especially with elevated HbA1c
New review shows SGLT2 drugs raise DKA risk when blood sugar is high
This meta-analysis of observational and randomized trials found SGLT2 inhibitor use is associated with an increased risk of diabetic ketoaci…
A big review of many studies found that medicines for diabetes called SGLT2 inhibitors can increase the chance of a serious condition called…
Perioperative anti-VEGF injections improve vision and reduce bleeding in proliferative diabetic retinopathy
Anti-VEGF injections before eye surgery improve vision and reduce bleeding in diabetic retinopathy
This network meta-analysis evaluated the timing of perioperative anti-VEGF injections for proliferative diabetic retinopathy. Results indica…
A network meta-analysis of 2,646 eyes found that perioperative anti-VEGF injections improved vision and reduced bleeding in patients with pr…
Scoping review maps burden of diabetic emergencies in African healthcare settings
Diabetic emergencies in Africa show wide variation in rates and outcomes
This scoping review synthesizes data from 25 studies regarding diabetic emergencies in Africa. The authors report wide variation in reported…
A review of 25 studies finds diabetic emergencies in Africa vary widely, with high death rates and long hospital stays.
Review of 16 cases shows 25% mortality for pulmonary mucormycosis in DKA patients treated with amphotericin B
Treatment for rare lung infection kills one in four patients with diabetic ketoacidosis
This case report and literature review synthesizes data from 16 patients with diabetic ketoacidosis complicated by invasive pulmonary mucorm…
A review of 16 patients found that one in four died from this rare lung infection. Early diagnosis and surgery are key.
Narrative review of salvianolic acids for kidney disease pharmacokinetics and anti-fibrotic activity
Salvianolic Acids Show Potential for Kidney Disease Treatment
This narrative review synthesizes evidence on salvianolic acids A, B, and C for kidney conditions. It focuses on pharmacokinetic parameters,…
A review suggests salvianolic acids may help kidney conditions, though low absorption and fast metabolism limit current use.
Review of immune checkpoint inhibitor-associated diabetes mellitus in two patients
Diabetes Danger Lingers Months After Cancer Treatment Ends
This narrative review and case report describes two patients with immune checkpoint inhibitor-associated diabetes mellitus. The authors synt…
• Some patients develop dangerous diabetes long after stopping immunotherapy • Helps cancer survivors using newer immune-boosting drugs • St…
Pregabalin 300 or 600 mg/day significantly reduces pain in painful diabetic peripheral neuropathy versus placebo
Higher doses of pregabalin helped reduce pain scores for people with painful diabetic nerve problems compared to placebo
This randomized controlled trial enrolled 729 patients with painful diabetic peripheral neuropathy. Pregabalin doses of 300 mg/day and 600 m…
A study found that taking 300 or 600 mg of pregabalin daily lowered pain scores better than a fake pill. Lower doses did not work as well fo…
Ranibizumab plus PRP reduces residual disc neovascularization versus monotherapy in proliferative diabetic retinopathy
Adding Laser to Eye Injections Cuts Treatment Burden for Diabetic Eye Disease
This retrospective cohort study included 238 patients with proliferative diabetic retinopathy.
Combining injections with laser treatment for diabetic eye disease significantly reduces future procedures and complications while preservin…
Questions about Diabetic Macular Edema
How does brolucizumab compare to aflibercept for treating diabetic macular edema over time?
Brolucizumab and aflibercept both improve vision in diabetic macular edema, but brolucizumab may allow longer intervals between injections while carrying a higher risk of intraocular inflammation.
Full answer →Are aflibercept biosimilars as safe and effective as the original drug for diabetic macular edema?
Yes, aflibercept biosimilars are as safe and effective as the original drug for diabetic macular edema, based on a systematic review and meta-analysis.
Full answer →Does taking aflibercept every 8 weeks keep vision gains in diabetic macular edema?
Yes, taking aflibercept every 8 weeks maintains vision gains in diabetic macular edema, as shown in a 96-week trial where the 2 mg every 8 weeks regimen kept visual improvements comparable to extended dosing of 8 mg.
Full answer →Is the new drug Pavblu approved for treating diabetic macular edema?
Yes, Pavblu (aflibercept) is FDA-approved for treating diabetic macular edema (DME).
Full answer →Can suprachoroidal injections help improve vision in diabetic macular edema?
Yes, early studies show suprachoroidal injections of triamcinolone can improve vision and reduce swelling in diabetic macular edema, but more research is needed.
Full answer →All Diabetic Macular Edema Articles
- Intravitreal ziv-aflibercept reduces central macular thickness and improves visual acuity in DME and RVO
- Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications
- Narrative review suggests suprachoroidal injections may improve vision and reduce edema in diabetic macular edema
- FDA Approves Pavblu (aflibercept) for Neovascular AMD, RVO, DME, and DR
- Aflibercept 8 mg extended dosing maintains visual gains with fewer injections versus 2 mg every 8 weeks in DME
- Systematic review and meta-analysis shows aflibercept biosimilars match reference drug efficacy and safety in AMD and DME
- Systematic review and meta-analysis finds no significant association between diabetic retinopathy and age-related macular degeneration
- Lower vitreous CREG1 levels associated with reduced ranibizumab response in diabetic macular edema
- OCT-A metrics show association with diabetic retinopathy status in cross-sectional study
- High LDL-C to HDL-C ratio linked to cardiovascular events in type 2 diabetes with retinopathy
- Systematic Review Finds Chinese and Western Medicine Combination May Improve Diabetic Retinopathy Outcomes
- Meta-analysis finds AI screening tools strongly associated with diabetic retinopathy detection
- Preclinical deep learning model for diabetic retinopathy screening in low-resource settings
- Three-parameter online nomogram predicts diabetic retinopathy risk in community-dwelling type 2 diabetes patients
- Cross-sectional review of diabetic retinopathy prevalence and risk factors in 384 Somaliland patients
- Meta-analysis links diabetic retinopathy with anxiety and depression in over 383,000 patients
- Post hoc analysis compares brolucizumab and aflibercept for diabetic macular edema
- Subretinal saline injection added to vitrectomy for diabetic macular edema with hard exudates
- FDA Approves Eylea HD (aflibercept) for nAMD, DME, Diabetic Retinopathy, and Macular Edema Following RVO
- CA-1 levels elevated in aqueous humor of DME patients compared to controls in cross-sectional study