LDHA promotes malignant progression and drug resistance while modulating tumor-infiltrating immune cell differentiation
New research identifies LDHA as a promising target for cancer
This systematic review examines the role of Lactate dehydrogenase A (LDHA) in malignant tumors and its impact on the immune microenvironment…
A specific protein called LDHA helps tumors grow and resist drugs, making it a potential new target to combine with existing immunotherapies…
Natural anti-inflammatory products modulate the FOXP3-C5aR1-LIF axis to potentially manage chronic rhinosinusitis
Natural Compounds May Help Manage Chronic Rhinosinusitis Symptoms
This systematic review examines natural anti-inflammatory compounds including epigallocatechin-3-gallate, curcumin, and rosmarinic acid in t…
Certain natural anti-inflammatory products like curcumin and bromelain may help manage the immune response in people with chronic sinusitis.
scTCR/BCR-seq enables identification of pathogenic clones and informs treatment response in autoimmune diseases
New Sequencing Methods Help Track Autoimmune Disease Progress
This systematic review examines the utility of scTCR/BCR-seq for analyzing immune cell dynamics in autoimmune disease. The analysis indicate…
Advanced cell sequencing can help doctors track how immune cells behave and predict how patients might respond to specific treatments.
Meningeal Immune System Offers New Target for Glioblastoma Immunotherapy
New approach targets the immune system to treat brain tumors
This systematic review explores how targeting the meningeal immune system, including dural lymphatics and rBAMs, could overcome current barr…
A new strategy focuses on the area where brain tumors meet the body's defenses to improve how immunotherapy works for glioblastoma.
Circular RNAs may regulate ferroptosis and anti-tumor immunity in cancer via multiple mechanisms
Circular RNAs may offer new ways to target cancer cells
This systematic review explores how circular RNAs (circRNAs) act as molecular bridges to simultaneously regulate ferroptosis and anti-tumor …
New research identifies circular RNAs as molecular bridges that could help doctors diagnose and treat cancer more precisely.
FDA Approves Exdensur for Add-On Maintenance Treatment of Severe Eosinophilic Asthma
FDA approves new long-acting shot Exdensur for severe asthma.
FDA approved Exdensur (IL-5 antagonist) for add-on maintenance treatment of severe eosinophilic asthma in patients aged 12 years and older. …
The FDA approved Exdensur as an add-on treatment for severe asthma in people 12 and older. It is given as a shot every six months. This new …
CD8+ T cells and associated signaling pathways influence osteoclast formation and osteoblast differentiation in osteoporosis
Immune Cells and Signaling Pathways Influence Bone Health in Osteoporosis
This narrative review synthesizes the role of CD8+ T cells and related cytokines like IFN-gamma, CCL5, and IL-33 in bone metabolism. The aut…
New research highlights how specific immune cells and signaling pathways may play a dual role in protecting or promoting bone loss in osteop…
E3 ubiquitin ligases modulate SARS-CoV-2 replication and immune evasion through targeted protein degradation mechanisms
SARS-CoV-2 uses host enzymes to hide from the immune system
This mini-review explores the role of E3 ubiquitin ligases in the context of SARS-CoV-2 infection. The authors synthesize how these enzymes …
New research shows how the virus hijacks specific proteins in our cells to replicate and dodge our body's natural defenses.
Mechanism-based strategies including CAR-T and bispecific engagers offer options for rituximab-resistant primary membranous nephropathy
New Strategies Target Treatment Resistance in Membranous Nephropathy
This systematic review examines the multifactorial mechanisms of rituximab resistance in patients with primary membranous nephropathy. It id…
Researchers identify new ways to treat primary membranous nephropathy when standard rituximab treatments do not work.
Multitarget designs and microenvironment remodeling may overcome resistance to CAR T-cell therapy in B-cell malignancies
New Strategies Identified to Overcome CAR T-cell Therapy Resistance
This systematic review synthesizes current knowledge regarding resistance mechanisms and overcoming strategies for CAR T-cell therapy in rel…
Researchers identified specific ways to overcome resistance in CAR T-cell therapy for patients with certain types of blood cancers.
Rare overlap of myasthenia gravis and Kennedy's disease identified in case report
Rare Overlap Syndrome Linked to Myasthenia Gravis and Kennedy's Disease
This case report and literature review describes a patient with acetylcholine receptor antibody-positive myasthenia gravis overlapping with …
A rare overlap between Myasthenia Gravis and Kennedy's disease was identified in a patient, helping doctors better recognize this complex co…
Innovative diagnostic techniques improve risk stratification and specificity in food allergy diagnosis
Newer tests help doctors identify real food allergy risks
This narrative review examines advanced diagnostic tools for food allergies, including component-resolved diagnostics and functional cellula…
Standard skin tests often fail to tell if a person is truly allergic, but new cellular assays provide more specific results for patients.