Necroptosis emerges as pathogenic hub in asthma, linking type 2 inflammation and steroid resistance
Necroptosis may drive severe inflammation in asthma cases
This systematic review posits necroptosis as an active pathogenic hub in asthma, driving type 2 inflammation, a neutrophilic steroid-refract…
New research identifies necroptosis as a potential driver of steroid-resistant inflammation and airway remodeling in patients with asthma.
Pola-R-CHP reduces progression risk 35% in double-expressor DLBCL, but OS unchanged
New Treatment Options Show Promise for Specific Lymphoma Patients
This network meta-analysis of 1,016 treatment-naïve patients with MYC/BCL2 double-expressor DLBCL found that Pola-R-CHP significantly reduce…
A new drug combination may reduce the risk of disease progression in patients with a specific type of lymphoma.
Training programs to teach behavioral mealtime interventions for children with food refusal and selectivity
Parent training helps kids with picky eating, review finds
This systematic review of 49 articles examines training procedures designed to teach parents or caregivers how to implement behavioral mealt…
A review of 49 studies finds training parents in mealtime strategies can help children who refuse food or eat very selectively.
Allergic conjunctivitis pathogenesis and endotypes point toward precision therapy
New insights into allergic conjunctivitis could lead to personalized treatments
This narrative review explores pathophysiological and molecular mechanisms of allergic conjunctivitis, including local and systemic immune r…
A review reveals how genetic and immune factors drive allergic conjunctivitis, paving the way for tailored therapies.
Extracellular vesicles show consistent presence and biological activity across diverse neonatal conditions
Small particles called extracellular vesicles show promise in neonatal health
This systematic review of 43 predominantly observational studies identifies the consistent presence and biological activity of extracellular…
Tiny particles called extracellular vesicles appear consistently in the fluids of newborns, potentially offering new ways to track and manag…
Biologic-assisted immunotherapy including omalizumab and dupilumab may support oral and sublingual immunotherapy for pediatric food allergies
New review explores biologic drugs for food allergy in children
This systematic review examines the efficacy, safety, and clinical applicability of biologic-assisted immunotherapies, such as omalizumab an…
A systematic review looks at whether adding biologic drugs like omalizumab to immunotherapy helps kids with food allergies.
Panax ginseng flower phytochemicals demonstrate antioxidant, anti-inflammatory, and cardiovascular protective effects for food ingredients
Ginseng Flowers Show Potential as Health Promoting Food Ingredients
This systematic review evaluates the phytochemical constituents and pharmacological activities of Panax ginseng flowers. The authors synthes…
Ginseng flowers contain specific compounds that may offer antioxidant and anti-inflammatory benefits in new food products like beverages.
Solid organ transplant recipients face higher cancer-related mortality with SMR 2.21 across multiple organs
Organ transplant recipients face higher risk of certain cancers
This meta-analysis of multi-centre cohort and registry-based studies indicates that solid organ transplant recipients experience significant…
People who receive heart or lung transplants face a significantly higher risk of dying from specific types of cancer.
Protein lactylation promotes tumor cell malignancy and drives immune evasion in the tumor microenvironment
Protein lactylation may fuel cancer growth and immune evasion
This systematic review examines the role of protein lactylation (Kla) in cancer progression and immunosuppression within the tumor microenvi…
A new review suggests that a protein modification called lactylation helps tumors grow and hide from the immune system.
101-PGC-005 achieves HR 2.31 for faster WHO scale improvement over dexamethasone in COVID-19
New drug beats dexamethasone for moderate COVID-19 recovery
This randomized Phase II/III trial of 309 hospitalized patients with moderate COVID-19 found that 101-PGC-005 (20 mg IV daily for 3 days) si…
A new drug helped hospitalized COVID-19 patients recover a day faster than dexamethasone, with similar safety.
Programmed cell death pathways form a spatiotemporally regulated network driving tubular damage in renal IRI
New research identifies key pathways driving acute kidney injury
This systematic review examines the roles of pyroptosis, ferroptosis, cuproptosis, and necroptosis as key mediators of inflammation and oxid…
Researchers have mapped out a complex network of cell death pathways that drive inflammation and damage in patients with acute kidney injury…
Anti-PD-1 based chemo-immunotherapy for nasopharyngeal carcinoma yields objective response rates of 20 to 91 percent
New Research Explores Treatments for Nasopharyngeal Carcinoma
This narrative synthesis reviews 182 studies regarding the mechanisms and treatments for nasopharyngeal carcinoma. It highlights that anti-P…
New research explores how immunotherapy and targeted treatments can improve outcomes for patients with nasopharyngeal carcinoma.