Dysregulation of the TOX/TCF-1 axis and IDH-mutation driven silencing drive cytotoxic failure in glioblastoma
Single-cell atlas reveals how glioblastoma disables immune cells
This systematic review examines the immunological landscape of glioblastoma, specifically focusing on cytotoxic lymphocyte dysfunction. The …
A systematic review maps the cellular and molecular mechanisms behind immune failure in glioblastoma, identifying key targets for future the…
System-level strategies and task-shifted care improve equity in global allergic disease management
Systemic Changes Could Improve Asthma Care in Underserved Communities
This guideline provides a narrative review of the global burden of allergic diseases, specifically focusing on underserved populations. It s…
New strategies like community health workers and digital tools could help bridge the gap in asthma care for underserved populations worldwid…
Mucus-barrier regulatory programs in Crohn's disease and ulcerative colitis involve ER stress and microbial sensing
New findings show how mucus barriers fail in Crohn's and Ulcerative Colitis
This meta-analysis of transcriptomic datasets and an Agr2-/- mouse model identifies consensus mucus-barrier regulatory programs in active IB…
Researchers found that specific genes control the protective mucus layer in the gut. These same pathways are disrupted in people with IBD.
Staphylococcal infections may mimic paradoxical psoriasis in patients receiving TNF-alpha inhibitors for systemic conditions
Skin infections can mimic psoriasis during certain medical treatments
This case report series describes 6 patients treated with TNF-alpha antagonists who developed skin lesions initially misdiagnosed as paradox…
Some patients treated for skin conditions may actually have a bacterial infection that looks like a flare-up of their original condition.
Casirivimab plus imdevimab reduced risk of hospitalization or death in patients with and without asthma
Trial shows antibody treatment helps COVID-19 patients with asthma
This randomized controlled trial evaluated casirivimab plus imdevimab (CAS + IMD) in outpatients with acute COVID-19. The study found that C…
A new trial shows a dual antibody treatment reduces hospitalization and death risk for COVID-19 patients, including those with asthma or ato…
Maternal free vitamin D linked to offspring asthma risk
Free Vitamin D in Pregnancy May Lower Child Asthma Risk
Maternal free 25OHD during pregnancy may better predict offspring asthma risk than total vitamin D, especially in mothers with asthma.
Mothers with asthma who had higher free vitamin D levels during pregnancy were less likely to have a child with asthma or wheeze by age 3.
Artificial intelligence as a mechanistic microscope and digital twin in colorectal cancer faces generalizability and regulatory validation limitations
Artificial intelligence acts as a digital microscope for colorectal cancer patients
This narrative review discusses the use of artificial intelligence as a mechanistic microscope and digital twin for patients with colorectal…
A review explores how artificial intelligence could help doctors see colorectal cancer better, though more testing is needed before patients…
Global allergy research grows 7.59% annually but risk-factor studies dominate, burden data scarce
Allergy research grows 7.6% yearly but misses key disease burden data
A systematic bibliometric and evidence-mapping review of 1,543 publications on allergic disorder epidemiology from 2016 to 2025 found a 7.59…
Allergy research is booming, but a new review finds most studies focus on risk factors, not the real-world burden of disease.
NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
New review reveals how inflammation drives osteoarthritis joint damage
This narrative review synthesizes evidence on NF-κB signaling as a central hub integrating mechanical stress, innate immunity, and metabolic…
A new review explains how mechanical stress, immune signals, and metabolism combine to drive osteoarthritis, pointing to smarter treatments.
Gut eosinophils emerge as central regulators of intestinal homeostasis and immunity
Gut immune cells may be key to intestinal health and disease
This narrative review synthesizes emerging evidence positioning gastrointestinal eosinophils as central regulators of intestinal homeostasis…
New research suggests gut eosinophils are not just allergy cells but central players in immunity, repair, and even cancer defense.
CAR technology for autoimmune disorders, infectious diseases, fibrotic lesions, inflammatory bowel disease, and type 1 diabetes is reviewed
Chimeric antigen receptor technology may help treat autoimmune disorders and other conditions
This narrative review discusses the application of chimeric antigen receptor (CAR) technology across autoimmune disorders, infectious diseas…
A narrative review suggests chimeric antigen receptor technology could be useful for treating autoimmune disorders, infectious diseases, and…
Endothelial ferroptosis blockade targets ischemic stroke and neurodegenerative conditions in brain microvascular endothelial cells
Ferroptosis blockade risks in brain microvascular endothelial cells need evaluation
This narrative review discusses endothelial ferroptosis blockade as a potential strategy for ischemic stroke, neurodegenerative conditions, …
A review suggests blocking ferroptosis in brain cells requires more study before use in stroke or neurodegenerative disease patients.