Sintilimab may trigger autoimmune GFAP astrocytopathy in esophageal squamous cell carcinoma patients
New cancer treatment may cause rare brain inflammation in patients
This case report and literature review describes a patient with advanced esophageal squamous cell carcinoma who developed autoimmune GFAP as…
A new type of immunotherapy for esophageal cancer can trigger a rare brain condition, requiring doctors to watch for early signs of neurolog…
Diverse therapeutic approaches including immunotherapy are utilized for patients with occult squamous cell carcinoma
Men and women show different patterns in squamous cell carcinoma
This systematic review of case reports examines clinical characteristics and treatment strategies for patients with occult squamous cell car…
New data shows that men and women experience different locations for lymph node spread in certain types of skin cancer.
Lower serum vitamin D levels correlate with increased severity in chronic rhinosinusitis
Lower Vitamin D Levels Linked to Worse Chronic Sinusitis
This meta-analysis of 1,236 patients found that individuals with chronic rhinosinusitis have significantly lower serum vitamin D levels (MD …
People with chronic rhinosinusitis often have lower vitamin D levels, which may be linked to more severe symptoms and a higher risk of recur…
Pneumococcal conjugate vaccines reduce antimicrobial resistance through direct suppression and reduced antibiotic exposure
Pneumococcal Vaccines May Help Reduce Antibiotic Resistance in Infections
This mini review examines the impact of pneumococcal conjugate vaccines (PCVs) on antimicrobial resistance dynamics and serotype replacement…
New research highlights how pneumococcal vaccines can help lower antibiotic resistance by reducing the need for treatment and limiting resis…
Immunosuppression with corticosteroids and cyclophosphamide leads to clinical improvement in AAV patients with hepatic granulomas
Treatment shows success for liver issues in specific autoimmune diseases
This systematic scoping review examines the rare manifestation of hepatic granulomatosis in patients with ANCA-associated vasculitides (AAV)…
Patients with rare liver granulomas and certain autoimmune conditions saw improvement when treated with standard immunosuppressive therapies…
OTUD1 serves as a potential biomarker for tumor prognosis and cardiovascular disease progression
Protein OTUD1 may help identify tumor stages and risks
This systematic review examines the role of OTUD1-mediated deubiquitination in tumors, cardiovascular diseases, and metabolic conditions. Th…
A protein called OTUD1 acts as a double-edged sword in the body, potentially serving as a key marker for cancer and heart disease progressio…
Mesenchymal stem cell transplantation shows no significant improvement in EDSS scores for progressive multiple sclerosis
Stem cell therapy safe but no benefit for multiple sclerosis
This meta-analysis of 143 patients with progressive multiple sclerosis found that mesenchymal stem cell transplantation did not significantl…
A new analysis finds stem cell transplants are safe for progressive MS but don't improve disability scores.
Chemoradiotherapy combined with immunotherapy improves progression-free and overall survival in limited-stage small-cell lung cancer
Immunotherapy Combined With Chemoradiotherapy Shows Promise for Lung Cancer
This meta-analysis of randomized controlled trials evaluated the impact of chemoradiotherapy (CCRT) plus immunotherapy on 1,853 patients wit…
Adding immunotherapy to standard chemoradiotherapy shows a favorable trend in survival for patients with limited-stage small-cell lung cance…
Neural-immune-cardiovascular axis emerges as therapeutic target in atherosclerosis, hypertension, heart failure
New pathways link nerves and immunity in heart disease
This systematic review synthesizes evidence on the neural-immune-cardiovascular axis in cardiovascular homeostasis and pathogenesis. It exam…
Scientists are mapping how the connection between your nervous system and immune cells may drive conditions like high blood pressure and hea…
Obinutuzumab achieves 86% overall clinical remission rate in refractory membranous nephropathy
Obinutuzumab shows promise for patients with hard to treat kidney disease
This meta-analysis evaluates the efficacy and safety of obinutuzumab for patients with refractory membranous nephropathy. The analysis repor…
A new treatment called obinutuzumab shows high remission rates for people with a rare, stubborn kidney condition known as membranous nephrop…
Regulatory and financing barriers primarily hinder optimal care delivery for hereditary angioedema in Balkan countries
Policy gaps create hurdles for patients with hereditary angioedema
This policy and practice review analyzes health systems and care delivery for hereditary angioedema across the Balkan Peninsula. The analysi…
Patients with hereditary angioedema face significant barriers to care, including long wait times for diagnosis and limited access to modern …
FTO-targeted strategies currently lack clinical evaluation and rely on preclinical evidence for cancer treatment
Targeting the FTO Protein May Improve Cancer Treatment Outcomes in Future Trials
This systematic review examines the role of FTO as a context-dependent epitranscriptomic regulator in cancer. The authors conclude that whil…
Scientists are looking at how targeting a specific protein called FTO could help patients who receive immunotherapy for cancer.