Systematic review of AI applications for protein misfolding diseases
AI Reveals Hidden Link Between Brain Proteins and Immune Attacks
This is a systematic review of artificial intelligence applications for neurodegenerative diseases involving protein misfolding. The authors…
• AI shows misfolded proteins trick the brain's immune system into attack mode • Helps adults with Alzheimer's and kids with rare brain diso…
Review links mature intra-tumoral TLS to better prognosis and immunotherapy response in head and neck cancer
Scientists found that special immune cells inside tumors help patients with head and neck cancer survive longer and respond better to treatment
This systematic literature review examines the role of tertiary lymphoid structures in patients with head and neck cancer. The authors synth…
A review of studies shows that mature immune cells found inside tumors are linked to better outcomes for patients with head and neck cancer.…
Meta-analysis shows dual ICI therapy improves survival in advanced metastatic non-small cell lung cancer
New analysis shows dual immune therapy helps patients with advanced lung cancer live longer and delays disease growth
This meta-analysis evaluates dual immune checkpoint inhibitor therapy versus control treatments in patients with advanced or metastatic non-…
A large review of 6,369 patients found that using two immune checkpoint drugs together improved survival time compared to standard treatment…
Review: Pregnane X Receptor Regulates Intestinal Homeostasis in Inflammatory Bowel Disease
Your Gut's Secret Inflammation Brake Just Got Stronger
This narrative review synthesizes evidence from mouse models on the role of the pregnane X receptor (Nr1i2) in inflammatory bowel disease. T…
A gut receptor controls inflammation like a brake pedal People with Crohn's disease or ulcerative colitis Mouse studies mean human treatment…
Network meta-analysis reveals induction immunochemotherapy plus CCRT improves survival for unresectable esophageal cancer patients compared to CCRT alone
Immunotherapy combinations show promise for hard-to-treat esophageal cancer
A comprehensive network meta-analysis of 9,648 patients indicates that induction immunochemotherapy followed by concurrent chemoradiotherapy…
Adding immunotherapy to standard treatment may help people with advanced esophageal cancer live longer, according to a new analysis of many …
Narrative review discusses therapeutic cancer vaccines and their potential role in future clinical paradigms
Cancer Vaccines May Stop Tumors From Coming Back
This narrative review examines therapeutic cancer vaccines (TCVs) and their potential role in oncology. The authors highlight significant ch…
New cancer vaccines may help prevent tumors from returning by training the immune system to target leftover cancer cells.
Overlapping IgG4-Related Nephritis and ANCA Glomerulonephritis in Elderly Woman
A Woman's Kidneys Show Two Rare Diseases at Once
An 81-year-old woman presented with concurrent IgG4-related tubulointerstitial nephritis and ANCA-associated glomerulonephritis, highlightin…
A new case report shows two rare kidney diseases can occur together, which helps doctors avoid misdiagnosis and choose the right treatment.
Review of metabolism-driven acylation modifications in COPD pulmonary cells
COPD May Be Driven by Hidden Cell Signals Doctors Can Now Target
This narrative review examines emerging acylation modifications like lactylation, succinylation, and crotonylation in pulmonary and immune c…
Hidden chemical tags in lung cells may drive COPD inflammation, opening paths for new targeted treatments and better biomarkers.
Narrative review explores succinylation roles in cancer biology and tumor heterogeneity
Understanding how chemical tags on DNA help doctors fight cancer better today
This narrative review examines the biological functions of succinylation, specifically focusing on writers, erasers, and readers within canc…
Doctors are learning how special chemical tags on DNA, called succinylation, might help stop cancer growth. This review explains the new sci…
Review of immune checkpoint inhibitor-associated diabetes mellitus in two patients
Diabetes Danger Lingers Months After Cancer Treatment Ends
This narrative review and case report describes two patients with immune checkpoint inhibitor-associated diabetes mellitus. The authors synt…
• Some patients develop dangerous diabetes long after stopping immunotherapy • Helps cancer survivors using newer immune-boosting drugs • St…
Review examines mRNA vaccines versus traditional platforms for colorectal cancer
New mRNA vaccines may help the body fight colorectal cancer
This narrative review synthesizes evidence on mRNA-based vaccines compared to traditional cancer vaccine platforms for colorectal cancer. Th…
Early trials show mRNA vaccines can train the immune system to target colorectal cancer with a manageable safety profile.
Systematic review and meta-analysis shows high atopic dermatitis prevalence in Ethiopia across regions
One in Eight Ethiopians Battles This Skin Condition Daily
This systematic review and meta-analysis synthesizes data from Ethiopian participants to estimate the pooled national prevalence of atopic d…
• Atopic dermatitis affects 12.75% of Ethiopians nationally • Helps doctors and families understand real skin disease impact • Not a treatme…