Integrated nutritional support strategies improve food access and early management of childhood malnutrition
Integrated Support Strategies Help Reduce Child Malnutrition Disparities
This narrative review synthesizes the effectiveness of policy, community, and healthcare-integrated strategies to reduce childhood malnutrit…
Combining policy, community engagement, and healthcare services can help children in disadvantaged areas access better nutrition and improve…
FDA Approves Joenja (leniolisib) for Activated PI3K Delta Syndrome in Patients 12 and Older
FDA Approves Joenja for Rare Immune Disorder in Patients 12 and Older
The FDA has approved Joenja (leniolisib) for the treatment of activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) in adults an…
The FDA approved Joenja (leniolisib) to treat activated PI3K delta syndrome, a rare immune condition. It is for patients 12 and older who we…
Umbilical cord-derived mesenchymal stromal cells balance immune homeostasis and offer potential for inflammatory disease treatment
Mesenchymal Stromal Cells Show Promise for Autoimmune and Immune Disorders
This systematic review examines the immunomodulatory properties and translational challenges of umbilical cord-derived mesenchymal stromal c…
Umbilical cord cells may help balance the immune system in conditions like lupus and rheumatoid arthritis, though long-term safety data is s…
Anti-rituximab antibodies are associated with lower rituximab levels and increased relapse rates in nephropathies
Antibodies may impact how well rituximab treats certain kidney diseases
This narrative review examines the prevalence and clinical implications of anti-rituximab antibodies (ADAs) in patients with nephropathies a…
Certain antibodies can lower the effectiveness of rituximab and lead to more frequent relapses in patients with kidney and immune diseases.
Thymectomy and immunotherapy improve symptoms in a patient with myasthenia gravis and paraneoplastic syndrome
Rare Nerve Damage Tied to Thymoma Improves After Treatment
This case report and literature review describes a 53-year-old male with myasthenia gravis, invasive thymoma, and CRMP5/CV2 antibody-positiv…
A 53-year-old man with myasthenia gravis and a rare paraneoplastic nerve syndrome improved after thymectomy and immunotherapy.
Expert consensus provides a framework for harmonizing HLH diagnosis and management in GCC countries
Experts Reach Consensus on Managing Hemophagocytic Lymphohistiocytosis
This consensus study utilizes a modified Delphi approach to establish management guidelines for hemophagocytic lymphohistiocytosis (HLH) in …
Experts in the Gulf region have agreed on new guidelines to help doctors identify and treat the rare condition HLH more effectively.
Cow's milk consumption supports physical growth, bone health, and cognitive performance in healthy children
Cow's Milk Offers Growth and Bone Benefits for Children
This expert review of 70 publications examines the safety and benefits of cow's milk consumption in children and adolescents. The authors co…
Cow's milk provides important nutrients for bone health and physical growth in children who do not have a milk allergy or lactose intoleranc…
Biologics provide effective and long-lasting disease control for chronic rhinosinusitis with nasal polyps
Biologics May Help Chronic Sinusitis With Nasal Polyps
This narrative review examines the efficacy of biologics, including dupilumab, mepolizumab, omalizumab, and tezepelumab, for patients with c…
A new review suggests biologic drugs may improve sinus symptoms, smell, and asthma in people with nasal polyps.
B-cell targeted therapies show durable immune responses in pemphigus vulgaris and myasthenia gravis
New data shows how B-cell therapies treat autoimmune diseases
This systematic review of 24 clinical trials involving more than 3,500 participants evaluates B-cell targeted therapies for various autoimmu…
New research highlights how targeting specific immune cells can provide lasting relief for several different autoimmune conditions.
MMR status-guided immunotherapy provides favorable cost-effectiveness and quality-adjusted survival in dMMR/MSI-H endometrial cancer
MMR Testing Helps Identify High Value Treatment for Endometrial Cancer
This mini review examines the economic value of mismatch repair (MMR) status-guided immunotherapy for advanced and recurrent endometrial can…
Testing for mismatch repair status helps doctors identify which patients with advanced endometrial cancer may benefit most from specific imm…
Mitophagy acts as a core barrier to effective immunotherapy in melanoma and other skin cancers
Mitophagy acts as a barrier to skin cancer immunotherapy
This narrative review explores how mitophagy functions as a barrier to immunotherapy in melanoma, cutaneous squamous cell carcinoma, and bas…
A cellular process called mitophagy may help skin cancers hide from the immune system, making it harder for certain treatments to work.
Add-on therapies fail to beat placebo in cutaneous sarcoidosis, but quality of life may improve
Corticosteroids Show Limited Success for Skin Sarcoidosis Treatment
This meta-analysis of 156 adults with cutaneous sarcoidosis found that pharmacological add-on therapies did not significantly improve clinic…
New analysis suggests that adding extra medications to corticosteroid treatment for skin sarcoidosis may not improve clinical results for pa…