B7-H3-targeted ADCs achieve 54% objective response rate in previously treated small cell lung cancer
B7-H3 Targeted Drugs Show Promise for Small Cell Lung Cancer
This systematic review and meta-analysis evaluates B7-H3-targeted antibody-drug conjugates for patients with previously treated small cell l…
New data suggests B7-H3 targeted therapies may offer higher response rates than standard treatments for patients with small cell lung cancer…
Ixekizumab Q2W shows highest P-score among IL-17 inhibitors for active psoriatic arthritis
New data shows IL-17 inhibitors work for psoriatic arthritis
This network meta-analysis of IL-17 pathway inhibitors in adults with active psoriatic arthritis found all active treatments superior to pla…
Several types of IL-17 pathway inhibitors show promise in treating joint pain and skin issues for people with active psoriatic arthritis.
Hematopoietic stem cell transplantation for Krabbe disease is associated with 84% overall survival
Stem Cell Transplant Shows Favorable Survival for Krabbe Disease
This meta-analysis of 15 studies involving 141 patients found that hematopoietic stem cell transplantation (HSCT) in Krabbe disease is assoc…
A review of 15 studies shows that stem cell transplants can improve survival rates for people with Krabbe disease, though neurological outco…
Neoadjuvant immune checkpoint inhibitors plus chemotherapy increase pathological complete response in early-stage triple-negative breast cancer
Immune checkpoint inhibitors improve response in triple-negative breast cancer
This meta-analysis of 3,377 patients found that neoadjuvant immune checkpoint inhibitors combined with chemotherapy significantly increased …
Adding immune checkpoint inhibitors to chemotherapy helps more patients with early-stage triple-negative breast cancer achieve a complete re…
Anti-CD6 monoclonal antibodies increase lymphocyte cytotoxicity against various human cancer cells in experimental systems
New antibody treatment shows promise for cancer and autoimmune diseases
This narrative review examines the potential of anti-CD6 monoclonal antibodies as a candidate immunotherapy for cancer. The authors synthesi…
A new type of antibody could help fight cancer while avoiding the common side effects seen with current immune treatments.
FDA Approves Xolair (omalizumab) for IgE-Mediated Food Allergy
FDA approves Xolair to reduce food allergy reactions
The FDA has approved Xolair (omalizumab) for the reduction of allergic reactions, including anaphylaxis, that may occur with accidental expo…
The FDA has approved Xolair to help reduce allergic reactions, including anaphylaxis, from accidental exposure to certain foods in people ag…
Antenatal factors in the fetal exposome may program neonatal immune development via epigenetic mechanisms
Maternal environment shapes how babies develop their immune systems
This narrative review synthesizes human and translational evidence regarding how maternal smoking, obesity, air pollution, heavy metals, and…
Factors like air pollution and maternal health can change how a baby's immune system develops before they are even born.
IL-10 Levels Predict Mortality in Severe Fever with Thrombocytopenia
Higher IL-10 Levels Linked to Worse Outcomes in SFTS Patients
Meta-analysis of 1,270 SFTS patients shows IL-10 levels significantly higher in non-survivors, with SMD 2.08, suggesting prognostic value.
High levels of a specific protein called IL-10 are linked to higher mortality rates in patients with severe fever and thrombocytopenia syndr…
Framework Maps Skin-Nose Link in Pediatric Allergy
New framework links eczema and allergic rhinitis in children
A new research framework explores how atopic dermatitis and allergic rhinitis may interact in children, guiding future studies.
A new research framework may explain why eczema and allergic rhinitis often occur together in children, but evidence is limited.
Intrinsic and extrinsic factors shape the unique aromatic profile of Qingke products during processing
Understanding the unique flavors and processing methods of specialty barley grains
This systematic review explores how genetic, environmental, and processing factors influence the flavor profiles of Qingke. The synthesis id…
Specialized barley varieties offer unique nutty and fruity flavors. These profiles are shaped by both natural genetics and specific cooking …
Three-dose HPV vaccine regimens provide highest seroconversion rates and protection against persistent infection
Three Dose HPV Vaccine Shows Highest Protection Against Infection
This network meta-analysis evaluates different HPV vaccine dose schedules (1D, 2D, and 3D) for females aged 9 to 26 years. The study finds t…
A review of vaccine data shows that a three-dose schedule provides the highest protection against certain HPV infections for girls and young…
PD-(L)1 plus VEGF monoclonal antibody shows most favorable overall survival in advanced hepatocellular carcinoma
New data identifies best immunotherapy combinations for advanced liver cancer
This meta-analysis of 15 phase III trials evaluated first-line immunotherapy combinations for advanced hepatocellular carcinoma. The analysi…
A large review of over 9,000 patients reveals which drug combinations offer the best survival rates and safety for advanced liver cancer.