Plasma cytokines and CSF ROS measured in MS phenotypes show associations with disability and cognition
New Clues Explain Why Some MS Patients Lose Mobility Without Inflammation
This multicenter cohort study measured plasma cytokines and CSF ROS in participants with MS and other neurological disorders.
A new study reveals that in a form of progressive MS without active inflammation, brain stress signals—not inflammation—predict disability a…
Protocol for HRF-HMO vs eHF-HMO in infants with suspected cow's milk allergy
New formula protocol aims to help infants with suspected cow's milk allergy grow normally
This randomized controlled blinded multi-center trial protocol evaluates a new hydrolyzed rice protein-based formula containing 2-fucosyllac…
A new formula designed for babies with suspected cow's milk allergy aims to support normal growth and comfort.
Systematic Bioinformatics Review Maps Asthma Molecular Architecture Across Thirty-One Cell Types
Brain Signals Worsen Asthma Symptoms in New Map
This systematic bioinformatics literature review examines the molecular systems architecture of asthma across thirty-one pulmonary, immune, …
A new molecular map reveals how stress and anxiety talk to your lungs to make asthma symptoms much worse for patients.
Vaccination season affects immunogenicity in children worldwide with latitudinal gradients
Vaccine power changes with the season of birth and weather
This RCT involving over 48,000 children worldwide found that immunogenicity follows a pronounced latitudinal gradient, typically peaking dur…
New data shows getting shots in colder months might boost immunity in temperate regions, suggesting a hidden seasonal rhythm to our immune s…
Peripheral immune patterns in severe fever with thrombocytopenia syndrome reveal plasma cell expansion
Doctors find a unique immune cell clue that predicts severe fever outcomes
This cohort study of 24 patients with SFTS and healthy controls found marked activation and exhaustion of T cells, expansion of T peripheral…
A rare immune cell spike predicts severe fever with thrombocytopenia syndrome, offering a new way to track patient recovery and guide treatm…
Early-Life Exposures Linked to Childhood Asthma in Canadian Cohort
New data links early exposures to childhood asthma risks
This Canadian cohort study followed 3,454 children from pregnancy to age 5 to assess associations between 2,954 early-life exposures and chi…
A massive new study connects childhood asthma to early life exposures like cleaning products and antibiotics.
EMS Bundle for Pediatric Life-Threatening Asthma Evaluated in PECARN Pilot
Early Meds Could Cut Hospital Stays for Wheezing Kids
This Phase 2 pilot trial in the Pediatric Emergency Care Applied Research Network assessed an EMS treatment bundle and checklist for childre…
Kids with severe asthma might avoid hospital stays if they get breathing meds right after the 911 call.
Scoping review explores microRNA-targeted reprogramming of CD8+ T cells and tumor cells in cancer
Tiny Switches That Control Cancer Immunity
This scoping review examines the potential of microRNA-targeted reprogramming affecting CD8+ T cells and tumor cells within the context of c…
Imagine your immune system as a security team patrolling your body.
Narrative review highlights mechanistic gaps and limited efficacy in chronic inducible urticaria treatment options
New Hope for Chronic Hives Targets Specific Triggers
This narrative review examines chronic inducible urticaria (CIndU), focusing on H1-antihistamines, omalizumab, anti-KIT biologics, and BTK i…
New medicines are being built to fix the exact reason your hives appear, moving away from a one-size-fits-all approach.
HBV-positive status linked to higher surgical conversion in unresectable HCC receiving triple therapy
HBV-positive linked to better outcomes in liver cancer triple therapy
This single-center retrospective cohort study evaluated triple therapy with TACE, lenvatinib, and PD-1 inhibitors in 190 patients with initi…
In unresectable liver cancer, triple therapy with TACE, lenvatinib, and PD-1 inhibitors worked better in HBV-positive patients, a small retr…
Narrative review offers mechano-immunology framework for keloid management strategies
Keloids May Be Driven by a Hidden Force You Can’t See
This narrative review synthesizes current understanding of keloid pathogenesis and treatment.
Understanding how tension fuels inflammation could change how we prevent and treat stubborn scars.
Narrative review on gamma delta T cell therapies for hematologic malignancies and immune cytopenias
New T-Cells Fight Blood Cancer Without Matching Your DNA
This narrative review synthesizes evidence on gamma delta T cell therapies for acute leukemias, lymphomas, multiple myeloma, and immune cyto…
A new type of immune cell could finally treat blood cancers that other therapies cannot touch.