HBV-positive status linked to higher surgical conversion in unresectable HCC receiving triple therapy
HBV-positive linked to better outcomes in liver cancer triple therapy
This single-center retrospective cohort study evaluated triple therapy with TACE, lenvatinib, and PD-1 inhibitors in 190 patients with initi…
In unresectable liver cancer, triple therapy with TACE, lenvatinib, and PD-1 inhibitors worked better in HBV-positive patients, a small retr…
Narrative review offers mechano-immunology framework for keloid management strategies.
Keloids May Be Driven by a Hidden Force You Can’t See
This narrative review synthesizes current understanding of keloid pathogenesis and treatment. The authors propose a novel theoretical framew…
Understanding how tension fuels inflammation could change how we prevent and treat stubborn scars.
Narrative review on gamma delta T cell therapies for hematologic malignancies and immune cytopenias
New T-Cells Fight Blood Cancer Without Matching Your DNA
This narrative review synthesizes evidence on gamma delta T cell therapies for acute leukemias, lymphomas, multiple myeloma, and immune cyto…
A new type of immune cell could finally treat blood cancers that other therapies cannot touch.
Narrative review outlines multimodal diagnostic strategies for Hymenoptera venom allergy and clonal mast-cell disorders.
Better Tests Could Save Lives After a Bee Sting
This narrative review synthesizes evidence regarding diagnostic modalities for Hymenoptera venom allergy, IgE-mediated anaphylaxis, and clon…
Doctors now have a clearer roadmap to find exactly who is at risk after a sting.
Review of case report discusses anti-PL-12 antisynthetase syndrome and NK/T-cell non-Hodgkin lymphoma
Patient with anti-PL-12 syndrome and lymphoma: a rare case report
This review of a case report describes a patient with anti-PL-12 antisynthetase syndrome and NK/T-cell non-Hodgkin lymphoma. The authors not…
A single patient with anti-PL-12 antisynthetase syndrome and NK/T-cell lymphoma highlights the need for caution when interpreting rare cance…
Scoping review details neurological involvement in relapsing polychondritis and VEXAS syndrome
Why Neurologists Must Watch These Two Conditions
This scoping review synthesizes evidence on neurological complications in relapsing polychondritis and VEXAS syndrome. The authors note that…
Imagine a patient with ear pain and red eyes.
HSCT in AK2-Related Reticular Dysgenesis: 85.7% Survival at 10 Years
Rare Immune Disorder: Early Transplant Restores Immunity in Newborns
This retrospective observational cohort study from a single high-consanguinity center evaluated 10 patients with AK2-related reticular dysge…
Early stem cell transplants may save babies with a rare immune disorder, restoring immunity and hearing stability in a small study.
Combined tebentafusp and SBRT showed disease control in a patient with metastatic uveal melanoma.
One Woman’s Rare Eye Cancer Spread. Then a New Combo Stopped It Cold.
This case report describes a 39-year-old woman with localized uveal melanoma who developed liver and hilar adenopathy metastases. She receiv…
This story shows how combining a new immune drug with targeted radiation may help the body fight cancer longer, even after it has spread.
Anti-centromere antibody-positive Sjögren's syndrome profile predicted by serologic and clinical factors
New Tool Predicts Hidden Risk in Sjögren’s Patients
This retrospective observational cohort study developed a predictive model for anti-centromere antibody-positive Sjögren's syndrome in 616 p…
Dry eyes. Dry mouth. Fatigue. For many with Sjögren’s syndrome, these are daily struggles.
Beta-cell stress responses contribute to early Type 1 diabetes development and disease progression.
Type 1 Diabetes May Start Inside the Cell, Not Just the Immune System
This perspective and review of human tissue, single cell transcriptomics, and longitudinal cohort studies indicates that beta-cell stress re…
This study shifts the focus of Type 1 diabetes from a pure immune problem to a two-part story where stressed cells play a key role.
Review of combination strategies for digestive system tumors including gastric and colorectal cancer
Unlocking New Ways to Beat Drug Resistance in Digestive Cancers
This review examines theoretical approaches to enhance efficacy in patients with digestive system tumors, including gastric, colorectal, and…
Researchers are finding better ways to combine treatments so drugs keep working longer.
Narrative review links microbiome dysbiosis to gynecological cancer pathogenesis and potential therapeutic applications.
Microbiome changes may help explain how gynecological cancers start and grow.
This narrative review examines the role of the human microbiome in gynecological malignancies, including cervical, ovarian, endometrial, vul…
New review suggests microbiome shifts could be key to understanding gynecological cancers, opening doors for better prevention and treatment…