Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
Genistein shows potential to attenuate inflammation and reduce disease severity in autoimmune conditions
Genistein may help reduce inflammation in several autoimmune diseases
This mini review synthesizes preclinical evidence on genistein for autoimmune diseases including SLE, RA, and type 1 diabetes. Findings sugg…
A review of genistein shows it could lower disease severity and inflammation for people with conditions like lupus and rheumatoid arthritis.
Single-cell and spatial omics provide detailed mapping of tumor-immune ecosystems in non-small cell lung cancer
New Mapping Tools May Improve Lung Cancer Treatment Planning
This mini review explores how single-cell RNA sequencing, chromatin profiling, and spatial transcriptomics offer superior resolution for ana…
Advanced mapping techniques are helping researchers identify how lung cancer cells adapt and hide from current treatments to help plan bette…
Lipid metabolism disorders drive podocyte injury and extracellular matrix deposition in diabetic kidney disease
Lipid metabolism issues drive damage to kidneys in diabetes
This systematic review examines the role of lipid metabolism in podocyte injury within diabetic kidney disease. The authors synthesize evide…
New research identifies how problems with fat processing in the body lead to specific cell damage in people with diabetic kidney disease.
Adalimumab and its biosimilar IBI303 show distinct response clusters in ankylosing spondylitis
Trial shows two different ways patients respond to adalimumab
This Phase III randomized controlled trial of 438 patients with active ankylosing spondylitis identified two longitudinal response clusters.…
A new study identifies two distinct groups of people with ankylosing spondylitis who react differently to the same treatment.
Genetic variant identification improves polygenic risk prediction for patients with asthma
New Genetic Mapping Improves Prediction of Asthma Risk
Researchers investigated genetic variants associated with asthma in a large cohort of individuals of European ancestry. The analysis identif…
Researchers used deep learning to identify 69 new genetic markers for asthma, improving how doctors can predict risk in people of European a…
Dendritic cell-based therapies face significant clinical translation barriers due to tumor microenvironment suppression
New ways to train immune cells to fight cancer
This mini review examines dendritic cell-based therapies including vaccines, nanoparticle delivery, and mRNA platforms for cancer treatment.…
Scientists are exploring how to reprogram the body's own defense cells to overcome hurdles in treating cancer.
Dysregulation of tRNA expression, modification, and tsRNAs is linked to tumor proliferation and therapy resistance
tRNA Dysregulation Linked to Cancer Growth and Treatment Resistance
This systematic review examines the role of tRNA expression, modifications, and derived small RNAs in cancer biology. The authors conclude t…
New research highlights how specific RNA molecules called tRNAs may play a key role in how cancer cells grow, spread, and resist medical tre…
Cytokine and endothelial markers show strong associations with severe dengue cases across 47,612 patients
Markers for severe dengue disease show promise in large data
This meta-analysis of 47,612 laboratory-confirmed dengue patients identifies significant associations between cytokine, chemokine, and endot…
New research identifies specific markers, like cytokine and endothelial signals, that may help predict which patients will develop severe ca…
Tumor-infiltrating pDCs lose interferon production despite nucleic acid exposure
Tumor Environment Limits Immune Cell Response to Cancer
This narrative review examines how tumor-derived nucleic acids fail to stimulate interferon-I production in plasmacytoid dendritic cells (pD…
New research identifies how the tumor environment suppresses specific immune cells, potentially opening doors for new ways to boost the body…
Therapeutic advances in IgE-mediated food allergy lack validated risk-stratification tools for individualized care
Newer treatments for food allergies lack clear safety tools
This mini review synthesizes therapeutic innovations for IgE-mediated food allergy, including oral immunotherapy, omalizumab, and combinatio…
Doctors are looking for better ways to manage food allergies, but they currently lack validated tools to help decide which specific treatmen…
Over one-third of workers with occupational asthma experience adverse occupational outcomes
Over One-Third of Workers with Occupational Asthma Face Job Hardships
This meta-analysis of 3,393 adults with occupational asthma found a pooled prevalence of 35.9% for adverse occupational outcomes (AOO). Sign…
More than one-third of workers with occupational asthma face serious job impacts like unemployment or disability, highlighting the need for …