Engineered nanobodies offer programmable platform to overcome limitations of conventional antibodies in angiogenic diseases
Engineered nanobodies may offer better ways to treat solid tumors
This systematic review examines engineered nanobodies targeting angiogenesis-related pathways for solid tumors and other conditions like wet…
Tiny engineered proteins called nanobodies could overcome the limitations of standard treatments for solid tumors and other blood vessel-rel…
Pyruvylation of STAT1 at Lys201 suppresses type I interferon signaling during high glucose glycolysis
Metabolic Changes May Influence Immune Responses and Inflammation
This systematic review examines how metabolite-driven protein modifications, specifically pyruvylation, influence immune signaling. The auth…
New research identifies how specific metabolic processes can alter protein modifications, potentially impacting how the body manages immune …
Serum complement C3 levels are elevated in polycystic ovary syndrome, meta-analysis finds
Higher Levels of Complement C3 Protein Found in People with Polycystic Ovary Syndrome
This meta-analysis of 915 individuals found that serum complement C3 levels are higher in patients with polycystic ovary syndrome (PCOS) tha…
A large review found that women with polycystic ovary syndrome often have higher levels of a specific protein called C3 in their blood.
Photoacoustic imaging enables label-free real-time tumor microenvironment visualization in oncology
New imaging technology helps doctors see tumor details in real time
This systematic review examines photoacoustic imaging (PAI) for oncology applications, highlighting its ability to provide label-free, real-…
A new type of imaging uses light to map oxygen levels and blood flow in tumors, helping surgeons see more during cancer treatment.
Welding fume exposure induces acute-phase proteins, cytokines, and neutrophilic responses in respiratory immune activation
Welding fumes trigger immune responses and airway inflammation
This mini review synthesizes findings on the impact of metal-rich welding fumes on respiratory immune markers. The authors conclude that the…
Research shows that metal-rich particles from welding can trigger inflammatory markers and weaken the body's ability to fight off bacterial …
EGFR inhibitors are associated with a 52.30% pooled incidence of all-grade rash in patients with tumors
EGFR inhibitors linked to rash in over half of patients
This meta-analysis of 65,116 patients receiving EGFR-targeted therapy found a pooled incidence of 52.30% for all-grade rash. Higher risks we…
A large analysis finds over half of patients on EGFR inhibitors develop a rash, with higher risk in Asian patients.
Mitochondrial dysfunction shapes immune cell function across sepsis phases, review finds
Mitochondrial Function Shapes Immune Response During Sepsis
This mini-review synthesizes evidence on mitochondrial immunometabolism in sepsis, describing how bioenergetic dysfunction and quality-contr…
New research highlights how mitochondrial health impacts immune cell function and organ damage during different stages of sepsis.
Azithromycin does not reduce severity of wheezing symptoms more than placebo in preschool children
Trial Shows Azithromycin Does Not Reduce Severity of Wheezing
This randomized controlled trial involving 840 preschool-age children with moderate-to-severe wheezing found no significant difference betwe…
A trial involving 840 preschool children found that azithromycin did not reduce the severity of wheezing symptoms compared to a placebo.
Finger millet supports sustainable nutrition and climate resilience as an underutilized grain for functional foods
Finger Millet Offers Nutrient Rich Food for Sustainable Nutrition
This systematic review of 147 peer-reviewed articles evaluates finger millet (Eleusine coracana) for its role in promoting sustainable nutri…
Finger millet is an underused grain rich in minerals like calcium and iron that shows great promise for nutrition and climate-resilient food…
Bidirectional virus-metabolism interaction in chronic hepatitis B and metabolic dysfunction-associated fatty liver disease
Liver disease and hepatitis B may fuel each other
This systematic review examines the interplay between viral infection and metabolic factors in patients with chronic hepatitis B and metabol…
Hepatitis B and fatty liver disease may worsen each other, raising liver cancer risk. New review explains the link.
Inflammatory ovarian remodeling drives premature ovarian insufficiency; cell therapy and mitochondrial protection emerge as targets
New research identifies potential targets for premature ovarian insufficiency
This mini review synthesizes preclinical evidence linking inflammatory ovarian remodeling to premature ovarian insufficiency (POI), highligh…
Researchers have identified specific cellular processes and immune responses that may offer new ways to treat early menopause.
Talquetamab monotherapy linked to 51% any-grade infection rate in relapsed/refractory myeloma
New data shows infection risks for patients on talquetamab
This systematic review and meta-analysis assessed infection risk with talquetamab in relapsed/refractory multiple myeloma. Pooled rates were…
Patients with relapsed or refractory multiple myeloma may face significant infection risks when treated with the drug talquetamab.